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Procedure: Transplants

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Total 141452 results found since Jan 2013.

Depletion of Airway Submucosal Glands and TP63+KRT5+ Basal Cells in Obliterative Bronchiolitis.
CONCLUSIONS: SMGs and basal SC compartments are depleted in large and/or small airways of lung allografts, and basal SC proliferative capacity declines with progression of disease and phenotypic changes. Global airway SC depletion may be a mechanism for pulmonary allograft failure. PMID: 29236513 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - December 13, 2017 Category: Respiratory Medicine Authors: Swatek AM, Lynch TJ, Crooke AK, Anderson PJ, Tyler SR, Brooks L, Ivanovic M, Klesney-Tait JA, Eberlein M, Pena T, Meyerholz DK, Engelhardt JF, Parekh KR Tags: Am J Respir Crit Care Med Source Type: research

Six-month Outcome of Immunocompromised Severe ARDS Patients Rescued by ECMO. An International Multicenter Retrospective Study.
CONCLUSION: Recently diagnosed immunodeficiency is associated with a much better prognosis in ECMO-treated severe ARDS. However, low 6-month survival of our large cohort of immunocompromised patients supports restricting ECMO to patients with realistic oncological/therapeutic prognoses, acceptable functional status and few pre-ECMO mortality-risk factors. PMID: 29298095 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - January 3, 2018 Category: Respiratory Medicine Authors: Schmidt M, Schellongowski P, Patroniti N, Taccone FS, Reis Miranda D, Reuter J, Prodanovic H, Pierrot M, Dorget A, Park S, Balik M, Demoule A, Crippa IA, Mercat A, Wohlfarth P, Sonneville R, Combes A, International ECMO Network (ECMONet), the REVA Researc Tags: Am J Respir Crit Care Med Source Type: research

Epithelial Progenitor Cells Take Center Stage in Lung Transplantation.
PMID: 29350973 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - January 19, 2018 Category: Respiratory Medicine Authors: Smirnova NF, Eickelberg O Tags: Am J Respir Crit Care Med Source Type: research

Lung Transplantation from Hepatitis C Viremic Donors to Uninfected Recipients.
PMID: 29412687 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - February 7, 2018 Category: Respiratory Medicine Authors: Abdelbasit A, Hirji A, Halloran K, Weinkauf J, Kapasi A, Lien D, Nagendran J, Doucette K Tags: Am J Respir Crit Care Med Source Type: research

Protective Role of Myelocytic Nitric Oxide Synthases Against Hypoxic Pulmonary Hypertension in Mice.
CONCLUSIONS: These results demonstrate that myelocytic n/i/eNOSs play an important protective role in the pathogenesis of PH. PMID: 29480750 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - February 26, 2018 Category: Respiratory Medicine Authors: Ogoshi T, Tsutsui M, Kido T, Sakanashi M, Naito K, Oda K, Ishimoto H, Yamada S, Wang KY, Toyohira Y, Izumi H, Masuzaki H, Shimokawa H, Yanagihara N, Yatera K, Mukae H Tags: Am J Respir Crit Care Med Source Type: research

Pulmonary Transplantation of Human iPSC-derived Macrophages Ameliorates Pulmonary Alveolar Proteinosis.
Conclusions We here demonstrate for the first time that pulmonary transplantation of human iPSC-derived macrophages leads to pulmonary engraftment, their in situ differentiation to an AM phenotype and a reduction of alveolar proteinosis in a humanized PAP model. To our knowledge, this finding presents the first proof-of-concept for the therapeutic potential of iPSC-derived cells in a pulmonary disease and may have profound implications beyond the rare disease of PAP. PMID: 29652170 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - April 13, 2018 Category: Respiratory Medicine Authors: Happle C, Lachmann N, Ackermann M, Mirenska A, Göhring G, Thomay K, Mucci A, Hetzel M, Glomb T, Suzuki T, Chalk C, Glage S, Dittrich-Breiholz O, Trapnell B, Moritz T, Hansen G Tags: Am J Respir Crit Care Med Source Type: research

Emphysema Management: From Investigational Endobronchial Coils to Lung Transplantation.
Abstract This brief imaging case report highlights a successful bridge to lung transplantation after endobronchial coil assisted lung volume reduction procedure. Our patient was a 64-year-old male with severe emphysema (FEV1:19%, RV: 289%, TLC: 143%), on maximum medical regimen who was enrolled into the Lung Volume Reduction Coil Treatment (RENEW) Study. He underwent bilateral endobronchial coil placement in a two-step procedure, with an immediate improvement in symptoms and pulmonary function testing (FEV1:21%, RV: 254%, TLC: 138%). The need for lung transplantation was delayed by three and half years because of ...
Source: American Journal of Respiratory and Critical Care Medicine - April 20, 2018 Category: Respiratory Medicine Authors: Grewal HS, Mehta AC Tags: Am J Respir Crit Care Med Source Type: research

Lung Dysbiosis, Inflammation, and Injury in Hematopoietic Cell Transplantation.
CONCLUSION: In animal models and human subjects, lung dysbiosis is a prominent feature of HCT. Lung dysbiosis is correlated with histologic, immunologic, and physiologic features of post-HCT pulmonary complications. Our findings suggest the lung microbiome may be an unappreciated target for the prevention and treatment of post-HCT pulmonary complications. PMID: 29878854 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - June 7, 2018 Category: Respiratory Medicine Authors: O'Dwyer DN, Zhou X, Wilke CA, Xia M, Falkowski NR, Norman KC, Arnold KB, Huffnagle GB, Murray S, Erb-Downward JR, Yanik GA, Moore BB, Dickson RP Tags: Am J Respir Crit Care Med Source Type: research

The Lung Microbiome in Hematopoietic Stem Cell Transplant: Where the Money Lies.
PMID: 30001493 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - July 12, 2018 Category: Respiratory Medicine Authors: McVerry BJ, Morris A Tags: Am J Respir Crit Care Med Source Type: research

Impaired CMV Immunity in Idiopathic Pulmonary Fibrosis Lung Transplant Recipients with Short Telomeres.
CONCLUSIONS: As the short telomere defect has been linked to the pathogenesis of IPF in some cases, our data indicate that impaired CMV immunity may be a systemic manifestation of telomere-mediated disease in these patients. Identifying this high-risk subset of lung transplant recipients has implications for risk assessment, management and potential strategies for averting posttransplant CMV morbidities. PMID: 30088779 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - August 8, 2018 Category: Respiratory Medicine Authors: Popescu I, Mannem H, Winters SA, Hoji A, Silveira F, McNally E, Pipeling MR, Lendermon EA, Morrell MR, Pilewski JM, Hanumanthu VS, Zhang Y, Gulati S, Shah PD, Iasella CJ, Ensor CR, Armanios M, McDyer JF Tags: Am J Respir Crit Care Med Source Type: research

Where the Chromosome Ends: Telomeres and CMV Risk in Lung Transplant Recipients.
PMID: 30160976 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - August 30, 2018 Category: Respiratory Medicine Authors: Greenland JR Tags: Am J Respir Crit Care Med Source Type: research

Prognosticating Outcomes in Interstitial Lung Disease by Mediastinal Lymph Node Assessment: An Observational Cohort Study with Independent Validation.
CONCLUSIONS: MLN enlargement predicts TFS and hospitalization risk in ILD, and is associated with decreased levels of a key circulating cytokine sCD40L. Incorporating MLN and cytokine findings into current prediction models might improve ILD prognostication. PMID: 30216085 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - September 14, 2018 Category: Respiratory Medicine Authors: Adegunsoye A, Oldham JM, Bonham C, Hrusch C, Nolan P, Klejch W, Bellam S, Mehta U, Thakrar K, Pugashetti JV, Husain AN, Montner SM, Straus CM, Vij R, Sperling AI, Noth I, Strek ME, Chung JH Tags: Am J Respir Crit Care Med Source Type: research

Clinical Significance of Upper Airway Virus Detection in Critically Ill Hematology Patients.
CONCLUSIONS: Respiratory virus detection in the upper airway by multiplex PCR assay is common in critically ill hematology patients. In patients with ARF, respiratory virus detection was independently associated with ICU mortality. Multiplex PCR assay may prove helpful for the risk stratification of hematology patients with ARF. Studies to understand whether respiratory tract viruses play a causal role in outcomes are warranted. PMID: 30230909 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - September 19, 2018 Category: Respiratory Medicine Authors: Legoff J, Zucman N, Lemiale V, Mokart D, Pène F, Lambert J, Kouatchet A, Demoule A, Vincent F, Nyunga M, Bruneel F, Contejean A, Mercier-Delarue S, Rabbat A, Lebert C, Perez P, Meert AP, Benoit D, Schwebel C, Jourdain M, Darmon M, Resche-Rigon M, Azoulay Tags: Am J Respir Crit Care Med Source Type: research

Development and Preliminary Validation of the Lung Transplant Quality of Life (LT-QOL) Survey.
CONCLUSION: The LT-QOL is a new multidimensional instrument that characterizes and quantifies health-related quality of life in lung transplant recipients. PMID: 30303408 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - October 10, 2018 Category: Respiratory Medicine Authors: Singer JP, Soong A, Chen J, Shrestha P, Zhuo H, Gao Y, Greenland JR, Hays SR, Kukreja J, Golden J, Gregorich SE, Stewart AL Tags: Am J Respir Crit Care Med Source Type: research

Bone Morphogenetic Protein 9 is a Mechanistic Biomarker of Portopulmonary Hypertension.
CONCLUSIONS: BMP9 is a sensitive and specific biomarker of PoPH, predicting transplant-free survival and the presence of PAH in liver disease. In rodent models, acquired deficiency of BMP9 signaling can predispose to or exacerbate PH, providing a possible mechanistic link between PoPH and heritable PAH. These findings describe a novel experimental model of severe PH that provides insight into the synergy between pulmonary vascular injury and diminished BMP9 signaling in the pathogenesis of PAH. PMID: 30312106 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - October 12, 2018 Category: Respiratory Medicine Authors: Nikolic I, Yung LM, Yang P, Malhotra R, Paskin-Flerlage SD, Dinter T, Bocobo GA, Tumelty KE, Faugno AJ, Troncone L, McNeil ME, Huang X, Coser KR, Lai CSC, Upton PD, Goumans MJ, Zamanian RT, Elliott CG, Lee A, Zheng W, Berasi SP, Huard C, Morrell NW, Chung Tags: Am J Respir Crit Care Med Source Type: research