Pulmonary Transplantation of Human iPSC-derived Macrophages Ameliorates Pulmonary Alveolar Proteinosis.

Conclusions We here demonstrate for the first time that pulmonary transplantation of human iPSC-derived macrophages leads to pulmonary engraftment, their in situ differentiation to an AM phenotype and a reduction of alveolar proteinosis in a humanized PAP model. To our knowledge, this finding presents the first proof-of-concept for the therapeutic potential of iPSC-derived cells in a pulmonary disease and may have profound implications beyond the rare disease of PAP.
PMID: 29652170 [PubMed - as supplied by publisher]

Source: American Journal of Respiratory and Critical Care Medicine - April 13, 2018 Category: Respiratory Medicine Authors: Happle C, Lachmann N, Ackermann M, Mirenska A, Göhring G, Thomay K, Mucci A, Hetzel M, Glomb T, Suzuki T, Chalk C, Glage S, Dittrich-Breiholz O, Trapnell B, Moritz T, Hansen G Tags: Am J Respir Crit Care Med Source Type: research