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Therapy: Corticosteroid Therapy
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International Differences in the Frequency of COPD Exacerbations Reported in Three Clinical Trials
CONCLUSIONS: Countries contributing to chronic obstructive pulmonary disease trials differ consistently in their reporting of health care-defined exacerbations. These differences help explain why large studies have been needed to show differences between treatments that decrease exacerbation risk.PMID:35363593 | DOI:10.1164/rccm.202111-2630OC
Source: American Journal of Respiratory and Critical Care Medicine - April 1, 2022 Category: Respiratory Medicine Authors: Peter M A Calverley Fernando J Martinez J ørgen Vestbo Christine R Jenkins Robert Wise David A Lipson Nicholas J Cowans Julie Yates Courtney Crim Bartolome R Celli Source Type: research
Targeting Type 2 Inflammation and Epithelial Alarmins in Chronic Obstructive Pulmonary Disease: A Biologics Outlook
Am J Respir Crit Care Med. 2023 Jun 22. doi: 10.1164/rccm.202303-0455CI. Online ahead of print.ABSTRACTChronic obstructive pulmonary disease (COPD) is a complex, heterogeneous, progressive inflammatory airway disease associated with significant impact on patients' lives, including morbidity and mortality, and significant health-care related costs. Current pharmacologic strategies, including first- and second-line therapies such as long-acting β2-agonists, long-acting muscarinic antagonists, inhaled corticosteroids, phosphodiesterase 4 inhibitors, and macrolides, provide relief in patients with COPD. However, many patients...
Source: American Journal of Respiratory and Critical Care Medicine - June 22, 2023 Category: Respiratory Medicine Authors: Klaus F Rabe Stephen Rennard Fernando J Martinez Bartolome R Celli Dave Singh Alberto Papi Mona Bafadhel Jigna Heble Amr Radwan Xavier Soler Juby A Jacob Nara Yamo Deniz Paul J Rowe Source Type: research
Nonspecific Interstitial Pneumonia: What Is the Optimal Approach to Management?
Semin Respir Crit Care Med 2016; 37: 378-394DOI: 10.1055/s-0036-1583176We reviewed current aspects of the clinical and pathogenic profile of nonspecific interstitial pneumonia (NSIP), to better elucidate the complex issue of management and treatment options for NSIP patients. Recent findings suggest that idiopathic NSIP is a complex clinical entity with a disease spectrum that includes at least three different phenotypes: NSIP associated with autoimmune features, emphysema, and familial interstitial lung disease. This distinction, based mainly on clinical findings, may be of critical importance when it comes to making a de...
Source: Seminars in Respiratory and Critical Care Medicine - May 26, 2016 Category: Respiratory Medicine Authors: Tomassetti, SaraRyu, Jay H.Piciucchi, SaraChilosi, MarcoPoletti, Venerino Source Type: research
Corticosteroid therapy in COVID-19 patients: don’t forget venous thromboembolism
Publication date: Available online 19 November 2020Source: Anaesthesia Critical Care & Pain MedicineAuthor(s): Loris Roncon, Marco Zuin, Giovanni Zuliani, Gianluca Rigatelli
Source: Anaesthesia, Critical Care and Pain Medicine - November 20, 2020 Category: Anesthesiology Source Type: research
Recurrent Severe Preschool Wheeze: From Pre-Specified Diagnostic Labels to Underlying Endotypes
CONCLUSIONS: We identified four clusters of severe preschool wheeze distinguished using sensitization, peripheral eosinophilia, lower airway neutrophilia and bacteriology.PMID:33961755 | DOI:10.1164/rccm.202009-3696OC
Source: American Journal of Respiratory and Critical Care Medicine - May 7, 2021 Category: Respiratory Medicine Authors: Polly F M Robinson Sara Fontanella Sachin Ananth Aldara Martin Alonso James Cook Daphne Kaya-de Vries Luisa Polo Silveira Lisa Gregory Clare Lloyd Louise Fleming Andrew Bush Adnan Custovic Sejal Saglani Source Type: research
Associations between Inhaled Corticosteroid in the First 6 Years of Life and Obesity Related Traits
Conclusions ICS use in early childhood was associated with increased BMI z-score at age six, an earlier adiposity rebound and a trend of association with increased android body fat percentage.PMID:33975528 | DOI:10.1164/rccm.202009-3537OC
Source: American Journal of Respiratory and Critical Care Medicine - May 12, 2021 Category: Respiratory Medicine Authors: Asja Kun øe Astrid Sevelsted Bo L Chawes Jakob Stokholm Anders Eliasen Martin Krakauer Klaus B ønnelykke Hans Bisgaard Source Type: research
FeNO Non-Suppression Identifies Corticosteroid-Resistant Type-2 Signaling in Severe Asthma
Am J Respir Crit Care Med. 2021 Jun 15. doi: 10.1164/rccm.202104-1040LE. Online ahead of print.NO ABSTRACTPMID:34129808 | DOI:10.1164/rccm.202104-1040LE
Source: American Journal of Respiratory and Critical Care Medicine - June 15, 2021 Category: Respiratory Medicine Authors: Simon Couillard Rahul Shrimanker Rekha Chaudhuri Adel H Mansur Lorcan P McGarvey Liam G Heaney Stephen J Fowler Peter Bradding Ian D Pavord Timothy S C Hinks MRC UK Refractory Asthma Stratification programme (RASP-UK) Source Type: research
Inhaled Corticosteroid Use in Early Childhood: A Risk for High BMI?
Am J Respir Crit Care Med. 2021 Jun 23. doi: 10.1164/rccm.202105-1177ED. Online ahead of print.NO ABSTRACTPMID:34161751 | DOI:10.1164/rccm.202105-1177ED
Source: American Journal of Respiratory and Critical Care Medicine - June 23, 2021 Category: Respiratory Medicine Authors: Perdita Permaul Wanda Phipatanakul Source Type: research
