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NIH State-of-the-Science Conference Statement: Role of active surveillance in the management of men with localized prostate cancer.
CONCLUSIONS: Prostate cancer screening with prostate-specific antigen (PSA) testing has identified many men with low-risk disease. Because of the very favorable prognosis of low-risk prostate cancer, strong consideration should be given to modifying the anxiety-provoking term "cancer" for this condition. Treatment of low-risk prostate cancer patients with radical prostatectomy or radiation therapy leads to side effects such as impotence and incontinence in a substantial number. Active surveillance has emerged as a viable option that should be offered to patients with low-risk prostate cancer. More than 100,000 men a year d...
Source: NIH Consensus and State of the Science Statements - November 16, 2014 Category: American Health Tags: NIH Consens State Sci Statements Source Type: research
NIH consensus development statement on management of hepatitis B.
CONCLUSIONS: The most important predictors of cirrhosis or hepatocellular carcinoma in persons who have chronic HBV are persistently elevated HBV DNA and ALT levels in blood. Other risk factors include HBV genotype C infection, male sex, older age, family history of hepatocellular carcinoma, and co-infection with HCV or HIV. The major goals of anti-HBV therapy are to prevent the development of progressive disease, specifically cirrhosis and liver failure, as well as hepatocellular carcinoma development and subsequent death. To date, no RCTs of anti-HBV therapies have demonstrated a beneficial impact on overall mortality, l...
Source: NIH Consensus and State of the Science Statements - November 16, 2014 Category: American Health Tags: NIH Consens State Sci Statements Source Type: research
NIH Consensus Statement on Management of Hepatitis C: 2002.
CONCLUSIONS: The incidence of newly acquired hepatitis C infection has diminished in the United States. This decline is largely due to a decrease in cases among IDUs for reasons that are unclear and, to a lesser extent, to testing of blood donors for HCV. The virus is transmitted by blood and such transmission now occurs primarily through injection drug use, sex with an infected partner or multiple partners, and occupational exposure. The majority of infections become chronic, and therefore the prevalence of HCV infections is high, with about 3 million Americans now estimated to be chronically infected. HCV is a leading ca...
Source: NIH Consensus and State of the Science Statements - November 16, 2014 Category: American Health Tags: NIH Consens State Sci Statements Source Type: research
Novel Metastatic Serous Epithelial Ovarian Cancer (SEOC) Mouse Models, Cell Lines, and Orthotopic Models Useful for Biomarker Discovery and Preclinical Testing
The high mortality rate from ovarian cancers can be attributed to late-stage diagnosis and lack of effective treatment. Despite enormous effort to develop better targeted therapies, platinum-based chemotherapy still remains the standard of care for ovarian cancer patients, and resistance occurs at a high rate. One of the rate limiting factors for translation of new drug discoveries into clinical treatments has been the lack of suitable preclinical cancer models with high predictive value. NCI CAPR has developed Tri-allelic K18-T121 tg/+ /Brca1 fl/fl /p53 fl/fl SEOC GEM Model, GEM-derived SEOC orthotopic mouse model, and ...
Source: NIH OTT Licensing Opportunities - July 26, 2016 Category: Research Authors: ajoyprabhu3 Source Type: research
Expanding Extramural Research Opportunities at the NIH Clinical Center (U01 Clinical Trial Optional)
Funding Opportunity PAR-18-879 from the NIH Guide for Grants and Contracts. The purpose of this FOA is to support extramural investigator-initiated clinical research in collaboration and partnership with intramural investigators at the NIH Clinical Center in Bethesda, MD. This new FOA will leverage the resources (inpatient and outpatient) and assets of the NIH Clinical Center (e.g., scientific, clinical trial and expertise, nursing, beds, critical care services, ambulatory care services, laboratories, imaging, biostatistics, protocol development, regulatory guidance, clinical trials management and safety oversight) in acc...
Source: NIH Funding Opportunities (Notices, PA, RFA) - July 26, 2018 Category: Research Source Type: funding
Heterocyclic Compounds for the Treatment of Hepatitis C Virus
The vast majority of people infected with Hepatitis C Virus (HCV) will have chronic infection. Over decades, this can lead to liver disease and liver cancer. In fact, HCV infection is the leading cause of liver transplants in the U.S. Several new drugs have recently come into the market that have changed the HCV treatment paradigm. However, the effectiveness of these new drugs can vary depending on the HCV genotype. Furthermore, all oral, interferon free therapeutic regimens for HCV infection will need combinations of drugs that target different aspects of the HCV life cycle. Thus, there is still the need for additional ne...
Source: NIH OTT Licensing Opportunities - August 24, 2018 Category: Research Authors: ajoyprabhu3 Source Type: research
NIH study finds islet transplants improve quality of life for people with Type I diabetes
A Phase III trial funded by the National Institutes of Health found that quality of life for people with type I diabetes improved dramatically following transplantation of insulin-producing pancreatic islets, according to data published this week in the journal Diabetes Care.
The 48-patient trial involved participants with hypoglycemia unawareness, a condition that renders them unable to sense when their blood sugar drops to a dangerous level.
Get the full story at our sister site, Drug Delivery Business News.
The post NIH study finds islet transplants improve quality of life for people with Type I diabetes appeared first on MassDevice.
Source: Mass Device - March 23, 2018 Category: Medical Devices Authors: Sarah Faulkner Tags: Clinical Trials Diabetes Research & Development National Institutes of Health (NIH) Source Type: news
Device for Selective Partitioning of Frozen Cellular Products
Technology Bundle IDTAB-2049
Device for Selective Partitioning of Frozen Cellular ProductsLinked IDE-173-2009-0Lead InventorsRichard Childs (NHLBI)Co-InventorsSumithira Vasu (CC)Development StagesPrototypeDevelopment StatusPrototypeICsNHLBICCCryopreservation using liquid nitrogen frozen polyvinyl bags allows for storing cellular materials for extended periods while maintaining their activity and viability. Such bags are commonly used in the clinic to store blood products including blood cells, plasma, hematopoietic stem cells, umbilical cord blood for future uses including transplantation. These materials, typically obtai...
Source: NIH OTT Licensing Opportunities - July 16, 2021 Category: Research Authors: ott8admin Source Type: research
Local intramuscular transplantation of autologous bone marrow mononuclear cells for critical lower limb ischaemia
CONCLUSIONS: We identified a small number of studies that met our inclusion criteria, and these differed in the controls they used and how they measured important outcomes. Limited data from these trials provide very low- to low-certainty evidence, and we are unable to draw conclusions to support the use of local intramuscular transplantation of BMMNC for improving clinical outcomes in people with CLI. Evidence from larger RCTs is needed in order to provide adequate statistical power to assess the role of this procedure.PMID:35802393 | PMC:PMC9266992 | DOI:10.1002/14651858.CD008347.pub4
Source: Cochrane Database of Systematic Reviews - July 8, 2022 Category: General Medicine Authors: Bobak Moazzami Zinat Mohammadpour Zohyra E Zabala Ermia Farokhi Aria Roohi Elena Dolmatova Kasra Moazzami Source Type: research
Fecal microbiota transplantation for the treatment of recurrent Clostridioides difficile (Clostridium difficile)
CONCLUSIONS: In immunocompetent adults with rCDI, FMT likely leads to a large increase in the resolution of recurrent Clostridioides difficile infection compared to alternative treatments such as antibiotics. There was no conclusive evidence regarding the safety of FMT for the treatment of rCDI as the number of events was small for serious adverse events and all-cause mortality. Additional data from large national registry databases might be required to assess any short-term or long-term risks with using FMT for the treatment of rCDI. Elimination of the single study that included some immunocompromised people did not alter...
Source: Cochrane Database of Systematic Reviews - April 25, 2023 Category: General Medicine Authors: Nathan Zev Minkoff Scheherzade Aslam Melissa Medina Emily E Tanner-Smith Joseph P Zackular Sari Acra Maribeth R Nicholson Aamer Imdad Source Type: research
Exercise interventions for adults after liver transplantation
CONCLUSIONS: Based on very low-certainty evidence in our systematic review, we are very uncertain of the role of exercise training (aerobic, resistance-based exercises, or both) in affecting mortality, health-related quality of life, and physical function (i.e. aerobic capacity and muscle strength) in liver transplant recipients. There were few data on the composite of cardiovascular mortality and cardiovascular disease, cardiovascular disease post-transplantation, and adverse event outcomes. We lack larger trials with blinded outcome assessment, designed according to the SPIRIT statement and reported according to the CONS...
Source: Cochrane Database of Systematic Reviews - May 19, 2023 Category: General Medicine Authors: Èlia Pérez-Amate Marta Roqu é-Figuls Miguel Fern ández-González Maria Gin é-Garriga Source Type: research
Prostaglandins for adult liver transplanted recipients
CONCLUSIONS: Eleven trials evaluated prostaglandins in adult liver transplanted recipients. Based on low-certainty evidence, prostaglandins may reduce all-cause mortality up to one month; may cause little to no difference in serious adverse events, liver retransplantation, early allograft dysfunction, primary non-function of the allograft, and length of hospital stay; and may have a large reduction in the development of acute kidney injury requiring dialysis. We do not know the effect of prostaglandins on adverse events considered non-serious. We lack adequately powered, high-quality trials evaluating the effects of prosta...
Source: Cochrane Database of Systematic Reviews - August 4, 2023 Category: General Medicine Authors: Zubair Umer Mohamed Christi Titus Varghese Abish Sudhakar Lakshmi Kumar Unnikrishnan Gopalakrishnan Dinesh Balakrishnan Ramachandran Narayanamenon Surendran Sudhindran Source Type: research
Machine perfusion in liver transplantation
CONCLUSIONS: In situations where the decision has been made to transplant a liver donated after circulatory death or donated following brain death, end-ischaemic HOPE will provide superior clinically relevant outcomes compared with SCS alone. Specifically, graft survival is improved (high-certainty evidence), serious adverse events are reduced (moderate-certainty evidence), and in donors after circulatory death, clinically relevant ischaemic biliary complications are reduced (high-certainty evidence). There is no good evidence that NMP has the same benefits over SCS in terms of these clinically relevant outcomes. NMP does ...
Source: Cochrane Database of Systematic Reviews - September 12, 2023 Category: General Medicine Authors: Samuel J Tingle Joseph J Dobbins Emily R Thompson Rodrigo S Figueiredo Balaji Mahendran Sanjay Pandanaboyana Colin Wilson Source Type: research
