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Vaccination: Malaria Vaccine
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Total 1513 results found since Jan 2013.
Infectious diseases in returned travellers, NSW, 2010-2011
CONCLUSION: A large proportion of selected enteric and vectorborne disease case notifications were associated with overseas travel. All potential travellers should be made aware of the risks and available preventive measures, such as vaccination against hepatitis A and typhoid fever, taking precautions with food and water and use of malaria chemoprophylaxis, where appropriate. Improvements in data on risk factors, reason for travel and barriers to the use of preventive measures would better inform prevention strategies.PMID:24939227 | DOI:10.1071/NB13005
Source: New South Wales Public Health Bulletin - June 19, 2014 Category: Health Management Authors: Praveena Gunaratnam Sean Tobin Holly Seale Jeremy M McAnulty Source Type: research
Immunoinformatics approach for multi-epitope vaccine design against P. falciparum malaria
In this study, an immunoinformatics method is presented to design a multi-epitope vaccine construct predicted to be effective against P. falciparum malaria. This was done through the prediction of 12 CD4+ T-cell, 10 CD8+ T-cell epitopes and, 1 B-cell epitope which were assessed for predicted high antigenicity, immunogenicity, and non-allergenicity through in silico methods. The Human Leukocyte Antigen (HLA) population coverage showed that the alleles associated with the epitopes accounted for 78.48% of the global population. The CD4+ and CD8+ T-cell epitopes were docked to HLA-DRB1*07:01 and HLA-A*32:01 successfully. There...
Source: Infection, Genetics and Evolution - April 27, 2021 Category: Genetics & Stem Cells Authors: Leah Maharaj Victoria T Adeleke Abiodun J Fatoba Adebayo A Adeniyi Selaelo I Tshilwane Matthew A Adeleke Rajendra Maharaj Moses Okpeku Source Type: research
Infectious diseases in returned travellers, NSW, 2010-2011
CONCLUSION: A large proportion of selected enteric and vectorborne disease case notifications were associated with overseas travel. All potential travellers should be made aware of the risks and available preventive measures, such as vaccination against hepatitis A and typhoid fever, taking precautions with food and water and use of malaria chemoprophylaxis, where appropriate. Improvements in data on risk factors, reason for travel and barriers to the use of preventive measures would better inform prevention strategies.PMID:24939227 | DOI:10.1071/NB13005
Source: New South Wales Public Health Bulletin - June 19, 2014 Category: Health Management Authors: Praveena Gunaratnam Sean Tobin Holly Seale Jeremy M McAnulty Source Type: research
Immunoinformatics approach for multi-epitope vaccine design against P. falciparum malaria
In this study, an immunoinformatics method is presented to design a multi-epitope vaccine construct predicted to be effective against P. falciparum malaria. This was done through the prediction of 12 CD4+ T-cell, 10 CD8+ T-cell epitopes and, 1 B-cell epitope which were assessed for predicted high antigenicity, immunogenicity, and non-allergenicity through in silico methods. The Human Leukocyte Antigen (HLA) population coverage showed that the alleles associated with the epitopes accounted for 78.48% of the global population. The CD4+ and CD8+ T-cell epitopes were docked to HLA-DRB1*07:01 and HLA-A*32:01 successfully. There...
Source: Infection, Genetics and Evolution - April 27, 2021 Category: Genetics & Stem Cells Authors: Leah Maharaj Victoria T Adeleke Abiodun J Fatoba Adebayo A Adeniyi Selaelo I Tshilwane Matthew A Adeleke Rajendra Maharaj Moses Okpeku Source Type: research
Infectious diseases in returned travellers, NSW, 2010-2011
CONCLUSION: A large proportion of selected enteric and vectorborne disease case notifications were associated with overseas travel. All potential travellers should be made aware of the risks and available preventive measures, such as vaccination against hepatitis A and typhoid fever, taking precautions with food and water and use of malaria chemoprophylaxis, where appropriate. Improvements in data on risk factors, reason for travel and barriers to the use of preventive measures would better inform prevention strategies.PMID:24939227 | DOI:10.1071/NB13005
Source: New South Wales Public Health Bulletin - June 19, 2014 Category: Health Management Authors: Praveena Gunaratnam Sean Tobin Holly Seale Jeremy M McAnulty Source Type: research
Immunoinformatics approach for multi-epitope vaccine design against P. falciparum malaria
In this study, an immunoinformatics method is presented to design a multi-epitope vaccine construct predicted to be effective against P. falciparum malaria. This was done through the prediction of 12 CD4+ T-cell, 10 CD8+ T-cell epitopes and, 1 B-cell epitope which were assessed for predicted high antigenicity, immunogenicity, and non-allergenicity through in silico methods. The Human Leukocyte Antigen (HLA) population coverage showed that the alleles associated with the epitopes accounted for 78.48% of the global population. The CD4+ and CD8+ T-cell epitopes were docked to HLA-DRB1*07:01 and HLA-A*32:01 successfully. There...
Source: Infection, Genetics and Evolution - April 27, 2021 Category: Genetics & Stem Cells Authors: Leah Maharaj Victoria T Adeleke Abiodun J Fatoba Adebayo A Adeniyi Selaelo I Tshilwane Matthew A Adeleke Rajendra Maharaj Moses Okpeku Source Type: research
Meeting report: WHO consultation on malaria vaccine development, Geneva, 15-16 July 2019
Vaccine. 2021 Apr 27:S0264-410X(21)00409-6. doi: 10.1016/j.vaccine.2021.03.093. Online ahead of print.ABSTRACTConsiderable progress has been made in malaria control in the last two decades, but progress has stalled in the last few years. New tools are needed to achieve public health goals in malaria control and elimination. A first generation vaccine, RTS,S/AS01, is currently being evaluated as it undergoes pilot implementation through routine health systems in parts of three African countries. The development of this vaccine took over 30 years and has been full of uncertainties. Even now, important unknowns remain as to i...
Source: Vaccine - May 1, 2021 Category: Allergy & Immunology Authors: Johan Vekemans David Schellenberg Sarah Benns Kate O'Brien Pedro Alonso Source Type: research
Infectious diseases in returned travellers, NSW, 2010-2011
CONCLUSION: A large proportion of selected enteric and vectorborne disease case notifications were associated with overseas travel. All potential travellers should be made aware of the risks and available preventive measures, such as vaccination against hepatitis A and typhoid fever, taking precautions with food and water and use of malaria chemoprophylaxis, where appropriate. Improvements in data on risk factors, reason for travel and barriers to the use of preventive measures would better inform prevention strategies.PMID:24939227 | DOI:10.1071/NB13005
Source: New South Wales Public Health Bulletin - June 19, 2014 Category: Health Management Authors: Praveena Gunaratnam Sean Tobin Holly Seale Jeremy M McAnulty Source Type: research
Repurposing Anticancer Drugs To Tackle Malaria
ChemMedChem. 2021 May 1. doi: 10.1002/cmdc.202100176. Online ahead of print.ABSTRACTDespite considerable efforts, malaria remains one of the most devastating infectious disease worldwide. In the absence of an effective vaccine, the prophylaxis and management of Plasmodium infections still rely on the therapeutic use of antimalarial agents. However, the emergence of resistant parasites has jeopardized the efficiency of virtually all antimalarial drugs, including artemisinin combination therapies (ACTs). Thus, there is an urgent need for innovative treatments with novel targets to avoid or overcome drug resistance. In this c...
Source: ChemMedChem - May 1, 2021 Category: Chemistry Authors: Yohann Le Govic Sandrine Houz é Nicolas Papon Source Type: research
Meeting report: WHO consultation on malaria vaccine development, Geneva, 15-16 July 2019
Vaccine. 2021 Apr 27:S0264-410X(21)00409-6. doi: 10.1016/j.vaccine.2021.03.093. Online ahead of print.ABSTRACTConsiderable progress has been made in malaria control in the last two decades, but progress has stalled in the last few years. New tools are needed to achieve public health goals in malaria control and elimination. A first generation vaccine, RTS,S/AS01, is currently being evaluated as it undergoes pilot implementation through routine health systems in parts of three African countries. The development of this vaccine took over 30 years and has been full of uncertainties. Even now, important unknowns remain as to i...
Source: Vaccine - May 1, 2021 Category: Allergy & Immunology Authors: Johan Vekemans David Schellenberg Sarah Benns Kate O'Brien Pedro Alonso Source Type: research
Infectious diseases in returned travellers, NSW, 2010-2011
CONCLUSION: A large proportion of selected enteric and vectorborne disease case notifications were associated with overseas travel. All potential travellers should be made aware of the risks and available preventive measures, such as vaccination against hepatitis A and typhoid fever, taking precautions with food and water and use of malaria chemoprophylaxis, where appropriate. Improvements in data on risk factors, reason for travel and barriers to the use of preventive measures would better inform prevention strategies.PMID:24939227 | DOI:10.1071/NB13005
Source: New South Wales Public Health Bulletin - June 19, 2014 Category: Health Management Authors: Praveena Gunaratnam Sean Tobin Holly Seale Jeremy M McAnulty Source Type: research
Repurposing Anticancer Drugs To Tackle Malaria
ChemMedChem. 2021 May 1. doi: 10.1002/cmdc.202100176. Online ahead of print.ABSTRACTDespite considerable efforts, malaria remains one of the most devastating infectious disease worldwide. In the absence of an effective vaccine, the prophylaxis and management of Plasmodium infections still rely on the therapeutic use of antimalarial agents. However, the emergence of resistant parasites has jeopardized the efficiency of virtually all antimalarial drugs, including artemisinin combination therapies (ACTs). Thus, there is an urgent need for innovative treatments with novel targets to avoid or overcome drug resistance. In this c...
Source: ChemMedChem - May 1, 2021 Category: Chemistry Authors: Yohann Le Govic Sandrine Houz é Nicolas Papon Source Type: research
Structural and immunogenicity analysis of reconstructed ancestral and consensus P48/45 for cross-species anti malaria transmission-blocking vaccine
In this study, we investigated the efficacy of P48/45 through the ancestral and consensus reconstruction approach. P48/45 phylogenetic and time tree analysis was done by RAXML and BEAST2. GRASP server and Ugene software were used to reconstruct ancestral and consensus sequences, respectively. The protein structural prediction was made by using a psipred and Rosetta program. Each protein characteristic of P48/45 was analyzed by assessing hydrophobicity and Post-Translational Modification sites. Meanwhile, the Epitope sequence for B-cell, T-cell, and HLA was determined using an immunoinformatics approach. Lastly, molecular d...
Source: Computational Biology and Chemistry - May 3, 2021 Category: Bioinformatics Authors: Kevin Nathanael Ramanto Rizky Nurdiansyah Source Type: research
Infectious diseases in returned travellers, NSW, 2010-2011
CONCLUSION: A large proportion of selected enteric and vectorborne disease case notifications were associated with overseas travel. All potential travellers should be made aware of the risks and available preventive measures, such as vaccination against hepatitis A and typhoid fever, taking precautions with food and water and use of malaria chemoprophylaxis, where appropriate. Improvements in data on risk factors, reason for travel and barriers to the use of preventive measures would better inform prevention strategies.PMID:24939227 | DOI:10.1071/NB13005
Source: New South Wales Public Health Bulletin - June 19, 2014 Category: Health Management Authors: Praveena Gunaratnam Sean Tobin Holly Seale Jeremy M McAnulty Source Type: research
Structural and immunogenicity analysis of reconstructed ancestral and consensus P48/45 for cross-species anti malaria transmission-blocking vaccine
In this study, we investigated the efficacy of P48/45 through the ancestral and consensus reconstruction approach. P48/45 phylogenetic and time tree analysis was done by RAXML and BEAST2. GRASP server and Ugene software were used to reconstruct ancestral and consensus sequences, respectively. The protein structural prediction was made by using a psipred and Rosetta program. Each protein characteristic of P48/45 was analyzed by assessing hydrophobicity and Post-Translational Modification sites. Meanwhile, the Epitope sequence for B-cell, T-cell, and HLA was determined using an immunoinformatics approach. Lastly, molecular d...
Source: Computational Biology and Chemistry - May 3, 2021 Category: Bioinformatics Authors: Kevin Nathanael Ramanto Rizky Nurdiansyah Source Type: research
