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Specialty: Physiology
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Total 33096 results found since Jan 2013.
Belumosudil, ROCK2-Specific Inhibitor, alleviates cardiac fibrosis by inhibiting cardiac fibroblasts activation
In conclusion, Belumosudil may be a promising therapeutic drug for cardiac hypertrophy and fibrosis induced by myocardial pressure overload.PMID:35657612 | DOI:10.1152/ajpheart.00014.2022
Source: American Journal of Physiology. Heart and Circulatory Physiology - June 3, 2022 Category: Physiology Authors: Quan Liu Hua-Yang Li Shun-Jun Wang Sui-Qing Huang Yuan Yue Adilai Maihemuti Yi Zhang Lin Huang Li Luo Kang-Ni Feng Zhong-Kai Wu Source Type: research
The Methodological Quality of Studies Investigating the Acute Effects of Exercise During Hypoxia Over the Past 40 years: A Systematic Review
Front Physiol. 2022 Jun 16;13:919359. doi: 10.3389/fphys.2022.919359. eCollection 2022.ABSTRACTExercise under hypoxia and the physiological impact compared to normoxia or hypoxia has gained attention in the last decades. However, methodological quality assessment of articles in this area is lacking in the literature. Therefore, this article aimed to evaluate the methodologic quality of trials studying exercise under hypoxia. An electronic search was conducted until December 2021. The search was conducted in PubMed, CENTRAL, and PEDro using the PICO model. (P) Participants had to be healthy, (I) exercise under normobaric or...
Source: Physiological Research - July 5, 2022 Category: Physiology Authors: Erich Hohenauer Livia Freitag Miriam Herten Julia Siallagan Elke Pollock Wolfgang Taube Ron Clijsen Source Type: research
Loss of sphingosine kinase 2 protects against cisplatin induced-kidney injury
Am J Physiol Renal Physiol. 2022 Jul 14. doi: 10.1152/ajprenal.00229.2021. Online ahead of print.ABSTRACTCisplatin is an established chemotherapeutic drug for treatment of solid-organ cancers, and is the primary drug utilized in the treatment of head and neck cancer; however, cisplatin-induced nephrotoxicity largely limits its clinical use. Inhibition of sphingosine kinase 2 (SphK2) has been demonstrated to alleviate various kidney diseases. Therefore, we hypothesized that inhibition of SphK2 could also protect against cisplatin-induced nephrotoxicity. Results from the present study showed that the SphK2 inhibitor, ABC2946...
Source: American Journal of Physiology. Renal Physiology - July 14, 2022 Category: Physiology Authors: Dengpiao Xie Gaizun Hu Chaoling Chen Fereshteh Ahmadinejad Weili Wang Pin-Lan Li David A Gewirtz Ningjun Li Source Type: research
β-PIX cooperates with GIT1 to regulate eNOS in sinusoidal endothelial cells
CONCLUSIONS: The data indicate that b-PIX regulates eNOS phosphorylation and function in normal SECs, and highlight the importance of the GIT1/b-PIX/eNOS trimolecular complex in normal liver SEC function.PMID:36044673 | DOI:10.1152/ajpgi.00034.2022
Source: American Journal of Physiology. Gastrointestinal and Liver Physiology - August 31, 2022 Category: Physiology Authors: Songling Liu Richard T Premont Ki-Hoon Park Don C Rockey Source Type: research
