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Antiresorptive and anabolic medications used in the perioperative period of patients with osteoporosis undergoing spine surgery: their impact on the biology of fusion and systematic review of the literature
CONCLUSIONS: Although antiosteoporosis agents are effective to varying degrees as treatments of patients with low BMD, teriparatide and bisphosphonates have been the most extensively studied with respect to spinal instrumentation. The advent of newer agents represents an area for further exploration, especially due to the current paucity of controlled investigations. It is imperative for spine surgeons to understand the mechanisms of action of these drugs and their effects on biology of fusion.PMID:34062504 | DOI:10.3171/2021.3.FOCUS201049
Source: Neurosurgical Focus - June 1, 2021 Category: Neurosurgery Authors: Jean-Paul Bryant Roberto J Perez-Roman S Shelby Burks Michael Y Wang Source Type: research
Visual or visual-tactile examination to detect and inform the diagnosis of enamel caries
CONCLUSIONS: Whilst the confidence intervals for the summary points of the different visual classification systems indicated reasonable performance, they do not reflect the confidence that one can have in the accuracy of assessment using these systems due to the considerable unexplained heterogeneity evident across the studies. The prediction regions in which the sensitivity and specificity of a future study should lie are very broad, an important consideration when interpreting the results of this review. Should treatment be provided as a consequence of a false-positive result then this would be non-invasive, typically th...
Source: Cochrane Database of Systematic Reviews - June 14, 2021 Category: General Medicine Authors: Richard Macey Tanya Walsh Philip Riley Anne-Marie Glenny Helen V Worthington Lucy O'Malley Janet E Clarkson David Ricketts Source Type: research
Antiresorptive and anabolic medications used in the perioperative period of patients with osteoporosis undergoing spine surgery: their impact on the biology of fusion and systematic review of the literature
CONCLUSIONS: Although antiosteoporosis agents are effective to varying degrees as treatments of patients with low BMD, teriparatide and bisphosphonates have been the most extensively studied with respect to spinal instrumentation. The advent of newer agents represents an area for further exploration, especially due to the current paucity of controlled investigations. It is imperative for spine surgeons to understand the mechanisms of action of these drugs and their effects on biology of fusion.PMID:34062504 | DOI:10.3171/2021.3.FOCUS201049
Source: Neurosurgical Focus - June 1, 2021 Category: Neurosurgery Authors: Jean-Paul Bryant Roberto J Perez-Roman S Shelby Burks Michael Y Wang Source Type: research
Visual or visual-tactile examination to detect and inform the diagnosis of enamel caries
CONCLUSIONS: Whilst the confidence intervals for the summary points of the different visual classification systems indicated reasonable performance, they do not reflect the confidence that one can have in the accuracy of assessment using these systems due to the considerable unexplained heterogeneity evident across the studies. The prediction regions in which the sensitivity and specificity of a future study should lie are very broad, an important consideration when interpreting the results of this review. Should treatment be provided as a consequence of a false-positive result then this would be non-invasive, typically th...
Source: Cochrane Database of Systematic Reviews - June 14, 2021 Category: General Medicine Authors: Richard Macey Tanya Walsh Philip Riley Anne-Marie Glenny Helen V Worthington Lucy O'Malley Janet E Clarkson David Ricketts Source Type: research
Antiresorptive and anabolic medications used in the perioperative period of patients with osteoporosis undergoing spine surgery: their impact on the biology of fusion and systematic review of the literature
CONCLUSIONS: Although antiosteoporosis agents are effective to varying degrees as treatments of patients with low BMD, teriparatide and bisphosphonates have been the most extensively studied with respect to spinal instrumentation. The advent of newer agents represents an area for further exploration, especially due to the current paucity of controlled investigations. It is imperative for spine surgeons to understand the mechanisms of action of these drugs and their effects on biology of fusion.PMID:34062504 | DOI:10.3171/2021.3.FOCUS201049
Source: Neurosurgical Focus - June 1, 2021 Category: Neurosurgery Authors: Jean-Paul Bryant Roberto J Perez-Roman S Shelby Burks Michael Y Wang Source Type: research
