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Procedure: Kidney Transplant
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Total 40381 results found since Jan 2013.
Direct oral anticoagulants versus warfarin for preventing stroke and systemic embolic events among atrial fibrillation patients with chronic kidney disease.
CONCLUSIONS: Our findings indicate that DOAC are as likely as warfarin to prevent all strokes and systemic embolic events without increasing risk of major bleeding events among AF patients with kidney impairment. These findings should encourage physicians to prescribe DOAC in AF patients with CKD without fear of bleeding. The major limitation is that the results of this study chiefly reflect CKD stage G3. Application of the results to CKD stage G4 patients requires additional investigation. Furthermore, we could not assess CKD stage G5 patients. Future reviews should assess participants at more advanced CKD stages. Additio...
Source: Cochrane Database of Systematic Reviews - November 6, 2017 Category: General Medicine Authors: Kimachi M, Furukawa TA, Kimachi K, Goto Y, Fukuma S, Fukuhara S Tags: Cochrane Database Syst Rev Source Type: research
Peritoneal dialysis for acute kidney injury.
CONCLUSIONS: Based on moderate (mortality, recovery of kidney function), low (infectious complications), or very low certainty evidence (correction of acidosis) there is probably little or no difference between PD and extracorporeal therapy for treating AKI. Fluid removal (low certainty) and weekly delivered Kt/V (very low certainty) may be higher with extracorporeal therapy.
PMID: 29199769 [PubMed - as supplied by publisher]
Source: Cochrane Database of Systematic Reviews - December 4, 2017 Category: General Medicine Authors: Liu L, Zhang L, Liu GJ, Fu P Tags: Cochrane Database Syst Rev Source Type: research
Antibiotics for asymptomatic bacteriuria in kidney transplant recipients.
CONCLUSIONS: Currently, there is insufficient evidence to support routinely treating kidney transplant recipients with antibiotics in case of asymptomatic bacteriuria after transplantation, but data are scarce. Further studies assessing routine antibiotic treatment would inform practice and we await the results of three ongoing randomised studies, which may help resolve existing uncertainties.
PMID: 29390169 [PubMed - as supplied by publisher]
Source: Cochrane Database of Systematic Reviews - February 1, 2018 Category: General Medicine Authors: Coussement J, Scemla A, Abramowicz D, Nagler EV, Webster AC Tags: Cochrane Database Syst Rev Source Type: research
Antimicrobial lock solutions for preventing catheter-related infections in haemodialysis.
CONCLUSIONS: Antibiotic antimicrobial and combined (antibiotic-non antibiotic) lock solutions decreased the incidence of CRI compared to control lock solutions, whereas non-antibiotic lock solutions reduce CRI only for tunnelled CVC. The effect on thrombosis incidence is uncertain for all antimicrobial lock solutions. Our confidence in the evidence is low and very low; therefore, better-designed studies are needed to confirm the efficacy and safety of antimicrobial lock solutions.
PMID: 29611180 [PubMed - as supplied by publisher]
Source: Cochrane Database of Systematic Reviews - April 3, 2018 Category: General Medicine Authors: Arechabala MC, Catoni MI, Claro JC, Rojas NP, Rubio ME, Calvo MA, Letelier LM Tags: Cochrane Database Syst Rev Source Type: research
Treatment for hepatitis C virus-associated mixed cryoglobulinaemia.
CONCLUSIONS: To treat HCV-associated mixed cryoglobulinaemia, it may be beneficial to eliminate HCV infection by using antiviral treatment and to stop the immune response by using rituximab. For skin vasculitis and for some laboratory findings, it may be appropriate to combine antiviral treatment with deletion of B-cell clonal expansions by using of rituximab. The applicability of evidence reviewed here is limited by the absence of any studies with direct-acting antivirals, which are urgently needed to guide therapy.
PMID: 29734473 [PubMed - as supplied by publisher]
Source: Cochrane Database of Systematic Reviews - May 7, 2018 Category: General Medicine Authors: Montero N, Favà A, Rodriguez E, Barrios C, Cruzado JM, Pascual J, Soler MJ Tags: Cochrane Database Syst Rev Source Type: research
Immunosuppressive treatment for proliferative lupus nephritis.
CONCLUSIONS: In this review update, studies assessing treatment for proliferative lupus nephritis were not designed to assess death (all causes) or ESKD. MMF may lead to increased complete disease remission compared with IV cyclophosphamide, with an acceptable adverse event profile, although evidence certainty was low and included the possibility of no difference. Calcineurin combined with lower dose MMF may improve induction of disease remission compared with IV cyclophosphamide, but the comparative safety profile of these therapies is uncertain. Azathioprine may increase disease relapse as maintenance therapy compared wi...
Source: Cochrane Database of Systematic Reviews - June 29, 2018 Category: General Medicine Authors: Tunnicliffe DJ, Palmer SC, Henderson L, Masson P, Craig JC, Tong A, Singh-Grewal D, Flanc RS, Roberts MA, Webster AC, Strippoli GF Tags: Cochrane Database Syst Rev Source Type: research
Interventions for chronic non-hypovolaemic hypotonic hyponatraemia.
CONCLUSIONS: In people with chronic hyponatraemia, vasopressin receptor antagonists modestly raise serum sodium concentration at the cost of a 3% increased risk of it being rapid. To date there is very low certainty evidence for patient-important outcomes; the effects on mortality and health-related quality of life are unclear and do not rule out appreciable benefit or harm; there does not appear to be an important effect on cognitive function, but hospital stay may be slightly shorter, although available data are limited. Treatment decisions must weigh the value of an increase in serum sodium concentration against its sho...
Source: Cochrane Database of Systematic Reviews - June 28, 2018 Category: General Medicine Authors: Nagler EV, Haller MC, Van Biesen W, Vanholder R, Craig JC, Webster AC Tags: Cochrane Database Syst Rev Source Type: research
Phosphate binders for preventing and treating chronic kidney disease-mineral and bone disorder (CKD-MBD).
CONCLUSIONS: In studies of adults with CKD G5D treated with dialysis, sevelamer may lower death (all causes) compared to calcium-based binders and incur less treatment-related hypercalcaemia, while we found no clinically important benefits of any phosphate binder on cardiovascular death, myocardial infarction, stroke, fracture or coronary artery calcification. The effects of binders on patient-important outcomes compared to placebo are uncertain. In patients with CKD G2 to G5, the effects of sevelamer, lanthanum, and iron-based phosphate binders on cardiovascular, vascular calcification, and bone outcomes compared to place...
Source: Cochrane Database of Systematic Reviews - August 22, 2018 Category: General Medicine Authors: Ruospo M, Palmer SC, Natale P, Craig JC, Vecchio M, Elder GJ, Strippoli GF Tags: Cochrane Database Syst Rev Source Type: research
Insulin and glucose-lowering agents for treating people with diabetes and chronic kidney disease.
CONCLUSIONS: Evidence concerning the efficacy and safety of glucose-lowering agents in diabetes and CKD is limited. SGLT2 inhibitors and GLP-1 agonists are probably efficacious for glucose-lowering and DPP-4 inhibitors may be efficacious for glucose-lowering. Additionally, SGLT2 inhibitors probably reduce BP, heart failure, and hyperkalaemia but increase genital infections, and slightly increase creatinine. The safety profile for GLP-1 agonists is uncertain. No further conclusions could be made for the other classes of glucose-lowering agents including insulin. More high quality studies are required to help guide therapeut...
Source: Cochrane Database of Systematic Reviews - September 24, 2018 Category: General Medicine Authors: Lo C, Toyama T, Wang Y, Lin J, Hirakawa Y, Jun M, Cass A, Hawley CM, Pilmore H, Badve SV, Perkovic V, Zoungas S Tags: Cochrane Database Syst Rev Source Type: research
Low protein diets for non-diabetic adults with chronic kidney disease.
CONCLUSIONS: This review found that very low protein diets probably reduce the number of people with CKD 4 or 5, who progress to ESKD. In contrast low protein diets may make little difference to the number of people who progress to ESKD. Low or very low protein diets probably do not influence death. However there are limited data on adverse effects such as weight differences and protein energy wasting. There are no data on whether quality of life is impacted by difficulties in adhering to protein restriction. Studies evaluating the adverse effects and the impact on quality of life of dietary protein restriction are require...
Source: Cochrane Database of Systematic Reviews - October 4, 2018 Category: General Medicine Authors: Hahn D, Hodson EM, Fouque D Tags: Cochrane Database Syst Rev Source Type: research
Biocompatible dialysis fluids for peritoneal dialysis.
CONCLUSIONS: This updated review strengthens evidence that neutral pH, low GDP PD solution improves RRF and urine volume preservation with high certainty. These effects may be related to increased peritoneal solute transport and reduced peritoneal ultrafiltration, although the evidence for these outcomes is of low certainty due to significant heterogeneity and suboptimal methodological quality. Icodextrin prescription increased peritoneal ultrafiltration and mitigated uncontrolled fluid overload with moderate certainty. The effects of either neutral pH, low GDP solution or icodextrin on peritonitis, technique survival and ...
Source: Cochrane Database of Systematic Reviews - October 26, 2018 Category: General Medicine Authors: Htay H, Johnson DW, Wiggins KJ, Badve SV, Craig JC, Strippoli GF, Cho Y Tags: Cochrane Database Syst Rev Source Type: research
Randomized Trials of Autologous Hematopoietic Stem Cell Transplantation for Diffuse Cutaneous Systemic Sclerosis: Systematic Review and Meta-Analysis with Trial Sequential Analysis of Overall Mortality
Conclusions. Our analysis has sufficient information size to indicate that autologous SCT for patients with SSc and internal organ involvement is safe and efficacious. The magnitude of the reduction in long-term mortality of autologous SCT over other available therapies may be practice changing.DisclosuresNo relevant conflicts of interest to declare.
Source: Blood - November 21, 2018 Category: Hematology Authors: Patel, A., Lim, Y. J. Tags: 731. Clinical Autologous Transplantation: Results: Autologous Transplantation: Clonal Hematopoiesis, Microbiota, AML, NHL, and Autoimmune Diseases Source Type: research
Omega-3 fatty acids for dialysis vascular access outcomes in patients with chronic kidney disease.
CONCLUSIONS: In CKD patients with an AVF, there is moderate certainty that ω-3FA supplementation makes little or no difference to preventing patency loss; and in patients with an AVG, it is very uncertain that ω-3FA supplementation prevents patency loss within 12 months.
PMID: 30480758 [PubMed - as supplied by publisher]
Source: Cochrane Database of Systematic Reviews - November 18, 2018 Category: General Medicine Authors: Tam KW, Wu MY, Siddiqui FJ, Chan ES, Zhu Y, Jafar TH Tags: Cochrane Database Syst Rev Source Type: research
Effects of peri-operative nonsteroidal anti-inflammatory drugs on post-operative kidney function for adults with normal kidney function.
CONCLUSIONS: Overall NSAIDs had uncertain effects on the risk of post-operative AKI, may slightly increase post-operative SCr, and it is uncertain whether NSAIDs lead to the need for RRT, death or increases the length of hospital stay. The available data therefore does not confirm the safety of NSAIDs in patients undergoing surgery. Further larger studies using the Kidney Disease Improving Global Outcomes definition for AKI including patients with co-morbidities are required to confirm these findings. .
PMID: 30488949 [PubMed - as supplied by publisher]
Source: Cochrane Database of Systematic Reviews - November 29, 2018 Category: General Medicine Authors: Bell S, Rennie T, Marwick CA, Davey P Tags: Cochrane Database Syst Rev Source Type: research
Timing of renal replacement therapy initiation for acute kidney injury.
CONCLUSIONS: Based mainly on low quality of evidence identified, early RRT may reduce the risk of death and may improve the recovery of kidney function in critically patients with AKI, however the 95% CI indicates that early RRT might worsen these outcomes. There was an increased risk of adverse events with early RRT. Further adequate-powered RCTs using appropriate criteria to define the optimal time of RRT are needed to reduce the imprecision of the results.
PMID: 30560582 [PubMed - as supplied by publisher]
Source: Cochrane Database of Systematic Reviews - December 18, 2018 Category: General Medicine Authors: Fayad AII, Buamscha DG, Ciapponi A Tags: Cochrane Database Syst Rev Source Type: research
