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Nutrition: Vitamins
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The magic of a methyl group: biochemistry at the service of medicine
Biochem Pharmacol. 2023 Sep 1:115786. doi: 10.1016/j.bcp.2023.115786. Online ahead of print.ABSTRACTA carbon-carbon linkage is created when a methyl group is implanted on dUMP, thus resulting in the formation of dTMP by thymidylate synthase. The methyl group is deleted by aromatase when androgens are converted to estrogens. The methyl group is rearranged with the help of vitamin B12 in the isomerization of methylmalonyl-CoA to succinyl-CoA. S-adenosylmethionine (SAM) serves as the universal methyl donor involved in the biosynthesis of adrenaline and creatine(phosphate). It also interferes with the 5'-mRNA capping and the d...
Source: Biochemical Pharmacology - September 3, 2023 Category: Drugs & Pharmacology Authors: Erik De Clercq Source Type: research
Periconceptional intakes of methyl donors and other micronutrients involved in one-carbon metabolism may further reduce the risk of neural tube defects in offspring: a United States population-based case-control study of women meeting the folic acid recommendations
CONCLUSIONS: Our findings support that NTD prevention, in the context of folic acid fortification, could be augmented with intakes of methyl donors and other micronutrients involved in folate metabolism.PMID:37661108 | DOI:10.1016/j.ajcnut.2023.05.034
Source: The American Journal of Clinical Nutrition - September 3, 2023 Category: Nutrition Authors: Julie M Petersen Rashida S Smith-Webb Gary M Shaw Suzan L Carmichael Tania A Desrosiers Eirini Nestoridi Anne Marie Darling Samantha E Parker Maria D Politis Mahsa M Yazdy Martha M Werler National Birth Defects Prevention Study Source Type: research
Vitamin D supplementation for improving bone density in vitamin D-deficient children and adolescents: systematic review and individual participant data meta-analysis of randomized controlled trials
CONCLUSIONS: Clinically important benefits for bone density from 1-y vitamin D supplementation in healthy children and adolescents, regardless of baseline vitamin D status, are unlikely. However, our findings are mostly generalizable to White postpubertal girls and do not apply to those with baseline 25(OH)D outside the studied range or with symptomatic vitamin D deficiency (e.g., rickets). This study was preregistered at PROSPERO as CRD42017068772. https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42017068772.PMID:37661104 | DOI:10.1016/j.ajcnut.2023.05.028
Source: The American Journal of Clinical Nutrition - September 3, 2023 Category: Nutrition Authors: Feitong Wu Ghada El-Hajj Fuleihan Guoqi Cai Christel Lamberg-Allardt Heli T Viljakainen Maya Rahme Ida M Gr ønborg Rikke Andersen Anuradha Khadilkar Mughal M Zulf Christian M ølgaard Anni Larnkj ær Kun Zhu Richard D Riley Tania Winzenberg Source Type: research
Health Benefits of Vitamin D Supplementation: Time to Move the Spotlight Away from Bone Health in Vitamin D-replete Individuals?
Am J Clin Nutr. 2023 Sep;118(3):489-490. doi: 10.1016/j.ajcnut.2023.06.017. Epub 2023 Aug 8.NO ABSTRACTPMID:37661100 | DOI:10.1016/j.ajcnut.2023.06.017
Source: The American Journal of Clinical Nutrition - September 3, 2023 Category: Nutrition Authors: Sue A Shapses Mona S Calvo Source Type: research
Periconceptional intakes of methyl donors and other micronutrients involved in one-carbon metabolism may further reduce the risk of neural tube defects in offspring: a United States population-based case-control study of women meeting the folic acid recommendations
CONCLUSIONS: Our findings support that NTD prevention, in the context of folic acid fortification, could be augmented with intakes of methyl donors and other micronutrients involved in folate metabolism.PMID:37661108 | DOI:10.1016/j.ajcnut.2023.05.034
Source: Am J Clin Nutr - September 3, 2023 Category: Nutrition Authors: Julie M Petersen Rashida S Smith-Webb Gary M Shaw Suzan L Carmichael Tania A Desrosiers Eirini Nestoridi Anne Marie Darling Samantha E Parker Maria D Politis Mahsa M Yazdy Martha M Werler National Birth Defects Prevention Study Source Type: research
Vitamin D supplementation for improving bone density in vitamin D-deficient children and adolescents: systematic review and individual participant data meta-analysis of randomized controlled trials
CONCLUSIONS: Clinically important benefits for bone density from 1-y vitamin D supplementation in healthy children and adolescents, regardless of baseline vitamin D status, are unlikely. However, our findings are mostly generalizable to White postpubertal girls and do not apply to those with baseline 25(OH)D outside the studied range or with symptomatic vitamin D deficiency (e.g., rickets). This study was preregistered at PROSPERO as CRD42017068772. https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42017068772.PMID:37661104 | DOI:10.1016/j.ajcnut.2023.05.028
Source: Am J Clin Nutr - September 3, 2023 Category: Nutrition Authors: Feitong Wu Ghada El-Hajj Fuleihan Guoqi Cai Christel Lamberg-Allardt Heli T Viljakainen Maya Rahme Ida M Gr ønborg Rikke Andersen Anuradha Khadilkar Mughal M Zulf Christian M ølgaard Anni Larnkj ær Kun Zhu Richard D Riley Tania Winzenberg Source Type: research
Health Benefits of Vitamin D Supplementation: Time to Move the Spotlight Away from Bone Health in Vitamin D-replete Individuals?
Am J Clin Nutr. 2023 Sep;118(3):489-490. doi: 10.1016/j.ajcnut.2023.06.017. Epub 2023 Aug 8.NO ABSTRACTPMID:37661100 | DOI:10.1016/j.ajcnut.2023.06.017
Source: Am J Clin Nutr - September 3, 2023 Category: Nutrition Authors: Sue A Shapses Mona S Calvo Source Type: research
Prediction of major bleeding events in 1381 patients with essential thrombocythemia
Int J Hematol. 2023 Sep 3. doi: 10.1007/s12185-023-03650-7. Online ahead of print.ABSTRACTThe goal of therapy in essential thrombocythemia (ET) is reducing thrombotic risk. No algorithm to predict hemorrhage risk exists. The impact ofanti-platelet, cytoreductive and anticoagulation therapies on risk of major bleeding (MB) was evaluated. MB events were retrospectively analyzed in 1381 ET from 10 European centers. There were 0.286 MB events/person-year. Neither the International Thrombosis Prognostic Score for thrombosis in essential thrombocythemia (IPSET-t) nor the revised IPSET-t (r-IPSET-t) was predictive for hemorrhage-...
Source: International Journal of Hematology - September 3, 2023 Category: Hematology Authors: Ruth Stuckey Jean-Christophe Ianotto Marco Santoro Anna Czy ż Manuel M Perez Encinas Mar ía Teresa Gómez-Casares Maria Soledad Noya Pereira Anna Kulikowska de Na łęcz Aleksandra Go łos Krzysztof Lewandowski Łukasz Szukalski Jes ús M González-Mart Source Type: research
Periconceptional intakes of methyl donors and other micronutrients involved in one-carbon metabolism may further reduce the risk of neural tube defects in offspring: a United States population-based case-control study of women meeting the folic acid recommendations
CONCLUSIONS: Our findings support that NTD prevention, in the context of folic acid fortification, could be augmented with intakes of methyl donors and other micronutrients involved in folate metabolism.PMID:37661108 | DOI:10.1016/j.ajcnut.2023.05.034
Source: The American Journal of Clinical Nutrition - September 3, 2023 Category: Nutrition Authors: Julie M Petersen Rashida S Smith-Webb Gary M Shaw Suzan L Carmichael Tania A Desrosiers Eirini Nestoridi Anne Marie Darling Samantha E Parker Maria D Politis Mahsa M Yazdy Martha M Werler National Birth Defects Prevention Study Source Type: research
Vitamin D supplementation for improving bone density in vitamin D-deficient children and adolescents: systematic review and individual participant data meta-analysis of randomized controlled trials
CONCLUSIONS: Clinically important benefits for bone density from 1-y vitamin D supplementation in healthy children and adolescents, regardless of baseline vitamin D status, are unlikely. However, our findings are mostly generalizable to White postpubertal girls and do not apply to those with baseline 25(OH)D outside the studied range or with symptomatic vitamin D deficiency (e.g., rickets). This study was preregistered at PROSPERO as CRD42017068772. https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42017068772.PMID:37661104 | DOI:10.1016/j.ajcnut.2023.05.028
Source: The American Journal of Clinical Nutrition - September 3, 2023 Category: Nutrition Authors: Feitong Wu Ghada El-Hajj Fuleihan Guoqi Cai Christel Lamberg-Allardt Heli T Viljakainen Maya Rahme Ida M Gr ønborg Rikke Andersen Anuradha Khadilkar Mughal M Zulf Christian M ølgaard Anni Larnkj ær Kun Zhu Richard D Riley Tania Winzenberg Source Type: research
Health Benefits of Vitamin D Supplementation: Time to Move the Spotlight Away from Bone Health in Vitamin D-replete Individuals?
Am J Clin Nutr. 2023 Sep;118(3):489-490. doi: 10.1016/j.ajcnut.2023.06.017. Epub 2023 Aug 8.NO ABSTRACTPMID:37661100 | DOI:10.1016/j.ajcnut.2023.06.017
Source: The American Journal of Clinical Nutrition - September 3, 2023 Category: Nutrition Authors: Sue A Shapses Mona S Calvo Source Type: research
Periconceptional intakes of methyl donors and other micronutrients involved in one-carbon metabolism may further reduce the risk of neural tube defects in offspring: a United States population-based case-control study of women meeting the folic acid recommendations
CONCLUSIONS: Our findings support that NTD prevention, in the context of folic acid fortification, could be augmented with intakes of methyl donors and other micronutrients involved in folate metabolism.PMID:37661108 | DOI:10.1016/j.ajcnut.2023.05.034
Source: Am J Clin Nutr - September 3, 2023 Category: Nutrition Authors: Julie M Petersen Rashida S Smith-Webb Gary M Shaw Suzan L Carmichael Tania A Desrosiers Eirini Nestoridi Anne Marie Darling Samantha E Parker Maria D Politis Mahsa M Yazdy Martha M Werler National Birth Defects Prevention Study Source Type: research
Vitamin D supplementation for improving bone density in vitamin D-deficient children and adolescents: systematic review and individual participant data meta-analysis of randomized controlled trials
CONCLUSIONS: Clinically important benefits for bone density from 1-y vitamin D supplementation in healthy children and adolescents, regardless of baseline vitamin D status, are unlikely. However, our findings are mostly generalizable to White postpubertal girls and do not apply to those with baseline 25(OH)D outside the studied range or with symptomatic vitamin D deficiency (e.g., rickets). This study was preregistered at PROSPERO as CRD42017068772. https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42017068772.PMID:37661104 | DOI:10.1016/j.ajcnut.2023.05.028
Source: Am J Clin Nutr - September 3, 2023 Category: Nutrition Authors: Feitong Wu Ghada El-Hajj Fuleihan Guoqi Cai Christel Lamberg-Allardt Heli T Viljakainen Maya Rahme Ida M Gr ønborg Rikke Andersen Anuradha Khadilkar Mughal M Zulf Christian M ølgaard Anni Larnkj ær Kun Zhu Richard D Riley Tania Winzenberg Source Type: research
Health Benefits of Vitamin D Supplementation: Time to Move the Spotlight Away from Bone Health in Vitamin D-replete Individuals?
Am J Clin Nutr. 2023 Sep;118(3):489-490. doi: 10.1016/j.ajcnut.2023.06.017. Epub 2023 Aug 8.NO ABSTRACTPMID:37661100 | DOI:10.1016/j.ajcnut.2023.06.017
Source: Am J Clin Nutr - September 3, 2023 Category: Nutrition Authors: Sue A Shapses Mona S Calvo Source Type: research
Periconceptional intakes of methyl donors and other micronutrients involved in one-carbon metabolism may further reduce the risk of neural tube defects in offspring: a United States population-based case-control study of women meeting the folic acid recommendations
CONCLUSIONS: Our findings support that NTD prevention, in the context of folic acid fortification, could be augmented with intakes of methyl donors and other micronutrients involved in folate metabolism.PMID:37661108 | DOI:10.1016/j.ajcnut.2023.05.034
Source: The American Journal of Clinical Nutrition - September 3, 2023 Category: Nutrition Authors: Julie M Petersen Rashida S Smith-Webb Gary M Shaw Suzan L Carmichael Tania A Desrosiers Eirini Nestoridi Anne Marie Darling Samantha E Parker Maria D Politis Mahsa M Yazdy Martha M Werler National Birth Defects Prevention Study Source Type: research
