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Total 85 results found since Jan 2013.
Xinmaikang-mediated mitophagy attenuates atherosclerosis via the PINK1/Parkin signaling pathway
CONCLUSION: The study shows that XMK is effective against AS by mediating macrophage mitophagy via the PINK1/Parkin signaling pathway. For the treatment of AS and drug discovery, it provides an experimental basis and target.PMID:37572567 | DOI:10.1016/j.phymed.2023.154955
Source: Atherosclerosis - August 12, 2023 Category: Cardiology Authors: Yanhong Cao Xin Chen Fuqiang Pan Mingyang Wang Haowen Zhuang Jiangna Chen Lu Lu Lingjun Wang Ting Wang Source Type: research
Intervention effect of Chuanxiong-Chishao herb pair on circRNA/lncRNA expression profile in a myocardial infarction-atherosclerosis model
This study aimed to explore the intervention effect of Chuanxiong-Chishao herb pair(CX-CS) on a myocardial infarction-atherosclerosis(MI-AS) mouse model and investigate its effect on the expression profile of circular RNAs(circRNAs)/long non-coding RNAs(lncRNAs) in ischemic myocardium and aorta. Sixty male ApoE~(-/-) mice were randomly assigned to a model group, high-, medium-, and low-dose CX-CS groups(7.8, 3.9, and 1.95 g·kg~(-1)), and a positive drug group(metoprolol 26 mg·kg~(-1) and simvastatin 5.2 mg·kg~(-1)), with 12 mice in each group. Male C57BL/6J mice were assigned to the sham group. The mice in the model gro...
Source: Atherosclerosis - July 20, 2023 Category: Cardiology Authors: Rong Yuan Zi-Han Li Mei-Wen Huang Peng-Qi Li Yu Miao Hui Mo Li Zeng Zhen-Yu Ju Qi-Qi Xin Wei-Hong Cong Source Type: research
Network Pharmacological Analysis of a New Herbal Combination Targeting Hyperlipidemia and Efficacy Validation In Vitro
In conclusion, the network pharmacologic approach was used to assess potential targets of the herbal combination for treatment. Experimental data from FFA-induced HepG2 cells suggested that the combination of AT, PC, and ZO might attenuate hyperlipidemia and its associated hepatic steatosis.PMID:36826031 | PMC:PMC9955970 | DOI:10.3390/cimb45020086
Source: Current Issues in Molecular Biology - February 24, 2023 Category: Molecular Biology Authors: Tae-Hyoung Kim Ga-Ram Yu Hyuck Kim Jai-Eun Kim Dong-Woo Lim Won-Hwan Park Source Type: research
