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Development and validation of capillary electrophoresis sodium dodecyl sulfate (CE-SDS) method for purity analysis of pertussis toxin, filamentous haemagglutinin and pertactin antigens
We report here the development and validation of CE-SDS method for purity analysis of Acellular Pertussis vaccine components viz. purified Pertussis toxin (PTx), purified Filamentous haemagglutinin (FHA), and Pertactinantigen (PRN). The method was found to be specific and showed excellent linearity at a concentration range of 15.62 µg/mL-1000 µg/mL for purified PTx, 31.25 µg/mL-1000 µg/mL for purified FHA, and 3.9 µg/mL-1000 µg/mL for PRN antigen. Method reported limit of quantification (LOQ) 31.25 µg/mL, 62.5 µg/mL, and 7.8 µg/mL for purified PTx, FHA, and PRN respectively. Method precision (repeatability and int...
Source: Vaccine - August 17, 2023 Category: Allergy & Immunology Authors: Shrikant Thorat Pratik Ogale Manish Gautam Umesh Shaligram Sunil Gairola Source Type: research

Outer Membrane Vesicles of Bordetella pertussis encapsulated into sodium alginate nanoparticles as novel vaccine delivery system
CONCLUSION: The results indicate the potential of OMV-NP as a novel vaccine delivery system.PMID:34493192 | DOI:10.2174/1381612827666210907154715
Source: Current Pharmaceutical Design - September 8, 2021 Category: Drugs & Pharmacology Authors: Abbas Rami Fatemeh Kazemi-Lomedasht Ali Mirjalili Mojtaba Noofeli Fereshteh Shahcheraghi Naser Mohammadpour Dounighi Source Type: research