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Vaccination: Covid Vaccine
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Total 110 results found since Jan 2013.
Engineering immunosuppressive drug-resistant armored (IDRA) SARS-CoV-2 T cells for cell therapy
Cell Mol Immunol. 2023 Sep 5. doi: 10.1038/s41423-023-01080-3. Online ahead of print.ABSTRACTSolid organ transplant (SOT) recipients receive immunosuppressive drugs (ISDs) and are susceptible to developing severe COVID-19. Here, we analyze the Spike-specific T-cell response after 3 doses of mRNA vaccine in a group of SOT patients (n = 136) treated with different ISDs. We demonstrate that a combination of a calcineurin inhibitor (CNI), mycophenolate mofetil (MMF), and prednisone (Pred) treatment regimen strongly suppressed the mRNA vaccine-induced Spike-specific cellular response. Such defects have clinical consequences bec...
Source: Cellular and Molecular Immunology - September 4, 2023 Category: Molecular Biology Authors: Qi Chen Adeline Chia Shou Kit Hang Amy Lim Wee Kun Koh Yanchun Peng Fei Gao Jili Chen Zack Ho Lu-En Wai Kamini Kunasegaran Anthony Tanoto Tan Nina Le Bert Chiew Yee Loh Yun Shan Goh Laurent Renia Tao Dong Anantharaman Vathsala Antonio Bertoletti Source Type: research
Immune responses and safety of COVID-19 vaccination in atypical hemolytic uremic syndrome patients in Taiwan
Vaccine. 2023 Aug 25:S0264-410X(23)00952-0. doi: 10.1016/j.vaccine.2023.08.020. Online ahead of print.ABSTRACTAtypical hemolytic uremic syndrome is a rare, life-threatening disorder which can be triggered by COVID 19 infection and COVID 19 vaccination then induce multiple organ failure. Our study is the first to evaluate immune responses to COVID-19 vaccination and safety in a cohort of patients in a local single-center study in Taiwan.. Results indicate that vaccines effectively shield aHUS patients from severe COVID-19 complications without significant safety concerns. A double booster dose for the third vaccine is essen...
Source: Vaccine - August 27, 2023 Category: Allergy & Immunology Authors: I-Ru Chen Guei-Jane Wang Po-Ren Hsueh Chia-Hui Chou Long-Bin Jeng Hui-Ju Lin Huang-Jiun Liao Ping-Chin Lai Jan-Gowth Chang Chiu-Ching Huang Source Type: research
Subunit vaccines with a saponin-based adjuvant boost humoral and cellular immunity to MERS coronavirus
Vaccine. 2023 Apr 10:S0264-410X(23)00390-0. doi: 10.1016/j.vaccine.2023.04.006. Online ahead of print.ABSTRACTMiddle East respiratory syndrome coronavirus (MERS-CoV) outbreaks have constituted a public health issue with drastic mortality higher than 34%, necessitating the development of an effective vaccine. During MERS-CoV infection, the trimeric spike protein on the viral envelope is primarily responsible for attachment to host cellular receptor, dipeptidyl peptidase 4 (DPP4). With the goal of generating a protein-based prophylactic, we designed a subunit vaccine comprising the recombinant S1 protein with a trimerization...
Source: Vaccine - April 21, 2023 Category: Allergy & Immunology Authors: Chi-Chieh Chang Abdullah Algaissi Chia-Chun Lai Chun-Kai Chang Jr-Shiuan Lin Yi-Shiang Wang Bo-Hau Chang Yu-Chiuan Chang Wei-Ting Chen Yong-Qing Fan Bi-Hung Peng Chih-Yu Chao Shiou-Ru Tzeng Pi-Hui Liang Wang-Chou Sung Alan Yung-Chih Hu Shin C Chang Ming-F Source Type: research
