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Specialty: Pathology
Nutrition: Antidoxidants
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Total 1054 results found since Jan 2013.
Rumex vesicarius L. boosts the effectiveness of sorafenib in triple-negative breast cancer by downregulating BCl2, mTOR, and JNK, and upregulating p21 expression
CONCLUSION: In conclusion, in vitro and in silico investigations show that the RMV extract improves the anticancer efficiency of SOR through molecular processes involving the downregulation of mTOR, BCl2, and JNK1 and overexpression of p21 tumor suppressor gene. Finally, we suggest conducting additional in vivo investigations on RMV and its bioactive components to verify their potential in cancer therapy.PMID:37696244 | DOI:10.1016/j.prp.2023.154807
Source: Pathology, Research and Practice - September 11, 2023 Category: Pathology Authors: Aml Ghanem Mohamed A Ali Mohamed A Elkady Sherif S Abdel Mageed Mahmoud A El Hassab Mohamed K El-Ashrey Osama A Mohammed Ahmed S Doghish Source Type: research
Involvement of antioxidant enzymes in Parkinson's disease
Pathol Res Pract. 2023 Aug 9;249:154757. doi: 10.1016/j.prp.2023.154757. Online ahead of print.ABSTRACTSimilar to many other diseases, the etiology of Parkinson's disease (PD) is multifactorial and includes both genetic and environmental factors. Exposure to pesticides and the production of reactive oxygen species (ROS) in the body, mainly in electron transporter complexes 1 and 2 in the inner mitochondrial membrane, are two primary environmental risk factors for this disease. Increased accumulation of ROS and oxidative stress (OS) trigger a series of reactions that can lead to the aggregation of misfolded proteins, DNA da...
Source: Pathology, Research and Practice - August 20, 2023 Category: Pathology Authors: Amir Tahavvori Morad Kohandel Gargari Yalda Yazdani Alireza Soleimani Mamalo Elmira Aboutalebi Vand Beilankouhi Mohammad Valilo Source Type: research
Protective effects of fisetin in an A β1-42-induced rat model of Alzheimer's disease
Folia Neuropathol. 2023;61(2):196-208. doi: 10.5114/fn.2023.126893.ABSTRACTAlzheimer's disease (AD) is a chronic, neurodegenerative disorder that affects the central nervous system and is found predominantly in elderly populations. As amyloid b protein (Ab) is one of the key players responsible for the pathogenesis of AD, we sought to investigate the protective effects of fisetin in an Ab1-42-induced rat model of AD. In this model, the protective effects of fisetin on learning and memory impairment induced by Ab1-42 were determined via the Morris water maze and passive avoidance test. Furthermore, the antioxidant activity,...
Source: Folia Neuropathologica - August 17, 2023 Category: Pathology Authors: Yunting Wang Xueling Wu Wujiang Ren Yanxia Liu Xueling Dai Shuo Wang Qing Huo Yaxuan Sun Source Type: research
