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Precancerous cervical lesions caused by non-vaccine-preventable HPV types after vaccination with the bivalent AS04-adjuvanted HPV vaccine: an analysis of the long-term follow-up study from the randomised Costa Rica HPV Vaccine Trial
Lancet Oncol. 2022 Jun 13:S1470-2045(22)00291-1. doi: 10.1016/S1470-2045(22)00291-1. Online ahead of print.ABSTRACTBACKGROUND: In women vaccinated against human papillomavirus (HPV), reductions in cervical disease and related procedures results in more women having intact transformation zones, potentially increasing the risk of cervical lesions caused by non-vaccine-preventable HPV types, a phenomenon termed clinical unmasking. We aimed to evaluate HPV vaccine efficacy against cervical intraepithelial neoplasia grade 2 or worse (CIN2+) and cervical intraepithelial neoplasia grade 3 or worse (CIN3+) attributed to non-preven...
Source: Cancer Control - June 16, 2022 Category: Cancer & Oncology Authors: Jaimie Z Shing Shangying Hu Rolando Herrero Allan Hildesheim Carolina Porras Joshua N Sampson John Schussler John T Schiller Douglas R Lowy M ónica S Sierra Loretto Carvajal Aim ée R Kreimer Costa Rica HPV Vaccine Trial Group Source Type: research

Weekly Overseas Health IT Links – 26th March, 2022.
Here are a few I came across last week.Note: Each link is followed by a title and few paragraphs. For the full article click on the link above title of the article. Note also that full access to some links may require site registration or subscription payment.-----https://mhealthintelligence.com/news/55-of-telehealth-providers-frustrated-with-overblown-patient-expectations55% of Telehealth Providers Frustrated With Overblown Patient ExpectationsProviders also cited their ability to provide quality care and technical difficulties as among their top frustrations with telehealth, a new survey shows.ByAnuja VaidyaMarch 18, 202...
Source: Australian Health Information Technology - March 26, 2022 Category: Information Technology Authors: Dr David G More MB PhD Source Type: blogs

Some Authoritative Skepticism about the "Triumph" of Sovaldi to Add to Outrage about "Blood Money"
This report just appeared online in JAMA Internal Medicine [Ollendorf DA, Tice JA et al.  The comparative clinical effectiveness and value of simeprevir and sofosbuvir in chronic hepatitis C viral infection.  JAMA Inte Med 2014.  Link here.] The review found again that there were major limitations in the available data, and so much of it was based on a network meta-analysis and simulation studies,The review was limited to patients with genotype 1, 2, and 3 infections, which account for most HCV cases in the United States. At the time of the review, no head-to-head trials of the direct-acting antiviral d...
Source: Health Care Renewal - May 7, 2014 Category: Health Management Tags: evidence-based medicine Gilead health care prices manipulating clinical research pharmaceuticals Sovaldi Source Type: blogs