Some Authoritative Skepticism about the "Triumph" of Sovaldi to Add to Outrage about "Blood Money"
This report just appeared online in JAMA Internal Medicine [Ollendorf DA, Tice JA et al. The comparative clinical effectiveness and value of simeprevir and sofosbuvir in chronic hepatitis C viral infection. JAMA Inte Med 2014. Link here.] The review found again that there were major limitations in the available data, and so much of it was based on a network meta-analysis and simulation studies,The review was limited to patients with genotype 1, 2, and 3 infections, which account for most HCV cases in the United States. At the time of the review, no head-to-head trials of the direct-acting antiviral drugs had been performed, and most of the data on sofosbuvir came from uncontrolled studies We therefore used network meta-analytic techniques to perform indirect comparisons of sustained virologic response outcomes across treatment options and used these results as the input to a simulation model that compared the estimated clinical and economic outcomes of treatment after 1 and 20 years.It is very hard for me to independently evaluate the credibility of these indirect methods of analysis of what amounts to sketchy data. However, I should note that Ollendorf et al did not some other specific problems with the available data on sofosbuvir:Yet at the time of this review there were several reasons for caution. First, the evidence base on the comparative clinical effectiveness of these 2 new drugs remained thin in most areas and notably incompl...
Source: Health Care Renewal - Category: Health Management Tags: evidence-based medicine Gilead health care prices manipulating clinical research pharmaceuticals Sovaldi Source Type: blogs
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