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Report of the third conference on next-generation sequencing for adventitious virus detection in biologics for humans and animals
Biologicals. 2023 Jul 19;83:101696. doi: 10.1016/j.biologicals.2023.101696. Online ahead of print.ABSTRACTNext-generation sequencing (NGS) has been proven to address some of the limitations of the current testing methods for adventitious virus detection in biologics. The International Alliance for Biological Standardization (IABS), the U.S. Food and Drug Administration (FDA), and the European Directorate for the Quality of Medicines and Healthcare (EDQM) co-organized the "3rd Conference on Next-generation Sequencing for Adventitious Virus Detection in Biologics for Humans and Animals", which was held on September 27-28, 20...
Source: Biologicals : Journal of the International Association of Biological Standardization - July 21, 2023 Category: Biotechnology Authors: Arifa S Khan Laurent Mallet Johannes Bl ümel Jean-Pol Cassart Ivana Knezevic Siemon H S Ng Michael Wall Miia Jakava-Viljanen Carine Logvinoff Ana Goios Pieter Neels Source Type: research

Monkeypox (Mpox) requires continued surveillance, vaccines, therapeutics and mitigating strategies
We describe here the vaccines and drugs available for the prevention and treatment of MPXV infections. However, although their efficacy against monkeypox (mpox) has been established in animal models, little is known about their efficacy in the current outbreak setting. The continuing opportunity for transmission raises concerns about the potential for evolution of the virus and for expansion beyond the current risk groups. The priorities for action are clear: 1) more data on the efficacy of vaccines and drugs in infected humans must be gathered; 2) global collaborations are necessary to ensure that government authorities w...
Source: Vaccine - April 23, 2023 Category: Allergy & Immunology Authors: Rachel L Roper Alfredo Garzino-Demo Carlos Del Rio Christian Br échot Robert Gallo William Hall Jos é Esparza Marvin Reitz Raymond F Schinazi Mark Parrington James Tartaglia Marion Koopmans Jorge Osorio Andreas Nitsche Tan Boon Huan James LeDuc Antoine Source Type: research

Factors associated with Q fever vaccination in Australian wildlife rehabilitators
This study aimed to determine factors associated with QFV status and describe AWR attitudes and potential barriers towards QFV. Data were obtained from a nationwide, online, cross-sectional survey of AWR undertaken in 2018. Approximately-three quarters (200/265; 75.5 %) of those that had heard of Q fever were also aware of the Q fever vaccine, and of those, 25.5 % (51/200) were vaccinated. Barriers to QFV, among unvaccinated respondents who had also heard of Q fever and the vaccine (149/200; 74.5 %), included concerns regarding the safety, efficacy, and importance of the Q fever vaccine. Complacency toward vaccination, con...
Source: Vaccine - November 24, 2022 Category: Allergy & Immunology Authors: Karen O Mathews Jacqueline M Norris David Phalen Nick Malikides Cathie Savage Paul A Sheehy Katrina L Bosward Source Type: research

News at a glance: Science moonshot, UC student strike, and an x-ray boost
LUNAR SCIENCE Science probes head for Moon orbit After years of delay, NASA’s Space Launch System (SLS) rocketed toward the Moon last week, and data indicate its scientific payloads are working as planned. The rocket is the agency’s most powerful since the Apollo-era Saturn V, and the launch marks the first orbital flight on a NASA rocket since the retirement of the Space Shuttle in 2011. The uncrewed mission, which will take the Orion capsule on a 26-day journey past the Moon and back, is the first in Artemis, NASA’s plan to return astronauts to the surface of the Moon by 2025. At an estimated $4 bill...
Source: Science of Aging Knowledge Environment - November 22, 2022 Category: Geriatrics Source Type: research

Merck locates frozen batch of undisclosed Ebola vaccine, will donate for testing in Uganda ’s outbreak
In a revelation that may help Uganda combat its outbreak of Ebola, the pharmaceutical giant Merck has acknowledged to Science— after repeated inquiries — that it has up to 100,000 doses of an experimental vaccine for the deadly viral disease in its freezers in Pennsylvania and will donate them. The World Health Organization (WHO) and the Ugandan government are discussing if and how these doses can be incorporated into one or more clinical trials of other candidate Ebola vaccines that could launch as soon as next month. The Merck vaccine targets Sudan ebolavirus, the pathogen currently circulating...
Source: ScienceNOW - October 23, 2022 Category: Science Source Type: news

The battle against malaria in Africa has stalled. Can research in Mozambique explain why?
.news-article__hero--featured .parallax__element{ object-position: 45% 50%; -o-object-position: 45% 50%; } .news-article__figure.inset { float: right !important; width: 33%; margin: 0.5rem 0 0.5rem 1rem; } @media (min-width: 576px) { .news-article__figure.inset { width: 25%; margin: 0.5rem 0 0.5rem 2rem; } } @media (min-width: 768px) { .news-article__figure.inset { width: 40%; margin: 0.5rem 0 0.5rem 1rem; } } Moisés Mapanga, a burly man of 49, is the bait. At 6 p.m. on a mid-April evening, he climbs into an orange tent outside his one-room house in Matutuíne, a hot, swampy district near Maputo, the cap...
Source: Science of Aging Knowledge Environment - September 8, 2022 Category: Geriatrics Source Type: research

The Macro View – Health, Economics, and Politics and the Big Picture. What I Am Watching Here And Abroad.
August 04, 2022 Edition-----The war seems to grind on sadly and Pres. Biden is having a second round with COVID as unprecedented weather happens all over the US. It all feels rather like ‘the end of days’!In the UK we see an increasing chance of a third female PM being elected as the country seems to be struggling. We do need to remember however the UK remains a significant power with nuclear weapons and home-grown nuclear submarines!In OZ we have had last week working out how to progress the First Nations ‘Voice’ as we wrap up the 1st session of Parliament for the new Government. Comments welcome on how you think ...
Source: Australian Health Information Technology - August 4, 2022 Category: Information Technology Authors: Dr David G More MB PhD Source Type: blogs

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