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The future of pyrogenicity testing: Phasing out the rabbit pyrogen test. A meeting report
Biologicals. 2023 Aug 27;84:101702. doi: 10.1016/j.biologicals.2023.101702. Online ahead of print.ABSTRACTThe rabbit pyrogen test (RPT) was the benchmark for pyrogenicity testing, but scientific advancements have provided innovative and humane methods, such as the in vitro monocyte-activation test (MAT). However, transitioning from the RPT to the MAT has been challenging. The European Directorate for the Quality of Medicines & HealthCare, the Council of Europe, and the European Partnership for Alternative Approaches to Animal Testing jointly hosted an international conference entitled "The future of pyrogenicity testin...
Source: Biologicals : Journal of the International Association of Biological Standardization - August 29, 2023 Category: Biotechnology Authors: Gwena ël Cirefice Katrin Sch ütte Ingo Spreitzer Emmanuelle Charton Shahjahan Shaid Laura Viviani Michelle Rubbrecht Irene Manou Source Type: research

Report of the third conference on next-generation sequencing for adventitious virus detection in biologics for humans and animals
Biologicals. 2023 Jul 19;83:101696. doi: 10.1016/j.biologicals.2023.101696. Online ahead of print.ABSTRACTNext-generation sequencing (NGS) has been proven to address some of the limitations of the current testing methods for adventitious virus detection in biologics. The International Alliance for Biological Standardization (IABS), the U.S. Food and Drug Administration (FDA), and the European Directorate for the Quality of Medicines and Healthcare (EDQM) co-organized the "3rd Conference on Next-generation Sequencing for Adventitious Virus Detection in Biologics for Humans and Animals", which was held on September 27-28, 20...
Source: Biologicals : Journal of the International Association of Biological Standardization - July 21, 2023 Category: Biotechnology Authors: Arifa S Khan Laurent Mallet Johannes Bl ümel Jean-Pol Cassart Ivana Knezevic Siemon H S Ng Michael Wall Miia Jakava-Viljanen Carine Logvinoff Ana Goios Pieter Neels Source Type: research

News at a glance: Science moonshot, UC student strike, and an x-ray boost
LUNAR SCIENCE Science probes head for Moon orbit After years of delay, NASA’s Space Launch System (SLS) rocketed toward the Moon last week, and data indicate its scientific payloads are working as planned. The rocket is the agency’s most powerful since the Apollo-era Saturn V, and the launch marks the first orbital flight on a NASA rocket since the retirement of the Space Shuttle in 2011. The uncrewed mission, which will take the Orion capsule on a 26-day journey past the Moon and back, is the first in Artemis, NASA’s plan to return astronauts to the surface of the Moon by 2025. At an estimated $4 bill...
Source: Science of Aging Knowledge Environment - November 22, 2022 Category: Geriatrics Source Type: research

The Macro View – Health, Economics, and Politics and the Big Picture. What I Am Watching Here And Abroad.
The objective most consistent with recent operations is to conquer Luhansk, Donetsk, and Kherson, with a view to their eventual annexation and Russification. But not only are they some way from achieving that (w ith much of Donetsk still in Ukrainian hands and the Russia position in Kherson highly contested) it would also require an explicit Ukrainian surrender for it to serve as the basis for a declaration of victory. That will not be forthcoming.-----https://www.afr.com/world/europe/how-britain-giggled-its-way-into-crisis-20220710-p5b0giHow Britain giggled its way into crisisBoris Johnson has exposed the costs of Britain...
Source: Australian Health Information Technology - July 21, 2022 Category: Information Technology Authors: Dr David G More MB PhD Source Type: blogs

Fight Aging! Newsletter, July 11th 2022
In this study we employ a transcriptome-wide and multi-tissue approach to analyze the influence of both LTDR and short-term DR (STDR) at old age on the aging phenotype. We were able to characterize a common transcriptional gene network driving inflammaging in most of the analyzed tissues. This network is characterized by chromatin opening and upregulation in the transcription of innate immune system receptors and by activation of interferon signaling through interferon regulatory factors, inflammatory cytokines, and Stat1-mediated transcription. We also found that both DR interventions ameliorate this inflammaging phenotyp...
Source: Fight Aging! - July 10, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

News at a glance: Webb telescope dinged, U.S.-Russia research paused, and NASA ’s UFO study
Table of contents A version of this story appeared in Science, Vol 376, Issue 6599. Download PDF ASTRONOMY Star mapper provides Milky Way portrait he European Space Agency’s Gaia satellite has now mapped almost 2 billion of the Milky Way’s stars, logging their positions, speeds, temperatures, and other parameters—and allowing astronomers to chart the Galaxy’s structure and evolution. Last week, operators released the third major trove of data, including lists of 800,000 binary stars, 10 million variable stars, and, within the Solar System, 156,000...
Source: Science of Aging Knowledge Environment - June 16, 2022 Category: Geriatrics Source Type: research

All Your Coronavirus Questions, Answered
One of the worst symptoms of any plague is uncertainty—who it will strike, when it will end, why it began. Merely understanding a pandemic does not stop it, but an informed public can help curb its impact and slow its spread. It can also provide a certain ease of mind in a decidedly uneasy time. Here are some of the most frequently asked questions about the COVID-19 pandemic from TIME’s readers, along with the best and most current answers science can provide. A note about our sourcing: While there are many, many studies underway investigating COVID-19 and SARS-CoV-19, the novel coronavirus that causes the illn...
Source: TIME: Health - April 14, 2020 Category: Consumer Health News Authors: TIME Staff Tags: Uncategorized COVID-19 Explainer Source Type: news

Fight Aging! Newsletter, August 29th 2016
This study demonstrates that TNTs play a significant part in the intercellular transfer of α-synuclein fibrils and reveals the specific role of lysosomes in this process. This represents a major breakthrough in understanding the mechanisms underlying the progression of synucleinopathies. These compelling findings, together with previous reports from the same team, point to the general role of TNTs in the propagation of prion-like proteins in neurodegenerative diseases and identify TNTs as a new therapeutic target to combat the progression of these incurable diseases. Shorter Period of Rapamycin Treatment in Mice...
Source: Fight Aging! - August 28, 2016 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Fight Aging! Newsletter, August 1st 2016
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more. This content is...
Source: Fight Aging! - July 31, 2016 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs