Fight Aging! Newsletter, August 29th 2016

This study demonstrates that TNTs play a significant part in the intercellular transfer of α-synuclein fibrils and reveals the specific role of lysosomes in this process. This represents a major breakthrough in understanding the mechanisms underlying the progression of synucleinopathies. These compelling findings, together with previous reports from the same team, point to the general role of TNTs in the propagation of prion-like proteins in neurodegenerative diseases and identify TNTs as a new therapeutic target to combat the progression of these incurable diseases. Shorter Period of Rapamycin Treatment in Mice Produces Greater Slowing of Aging https://www.fightaging.org/archives/2016/08/shorter-period-of-rapamycin-treatment-in-mice-produces-greater-slowing-of-aging/ Rapamycin, an immunosuppressant and MTOR inhibitor, is known to slow aging in mice - though it has been debated whether this extension of life span is actually a slowing of aging versus a lower rate of cancer. Researchers here try a variety of different treatment regimens and find that a comparatively short period of rapamycin treatment in mouse middle age produces better effects than the longer term dosage that has been standard in studies. The publicity materials emphasize the high points and the outliers in the mouse data; I'd recommend reading the paper for a more responsible and overall view of the outcomes. Even with improved results and possibly a new longevity record for thi...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs

Related Links:

CONCLUSION: The present findings show that Aβ and tau are differently affected in the chronic phase of severe TBI. PMID: 29792528 [PubMed - as supplied by publisher]
Source: Brain Injury - Category: Neurology Tags: Brain Inj Source Type: research
(MedPage Today) -- Hooking kids on nicotine a steep price to pay for helping some smokers quit, says Skeptical Cardiologist
Source: MedPage Today Cardiovascular - Category: Cardiology Source Type: news
Journal Name: Clinical Chemistry and Laboratory Medicine (CCLM) Issue: Ahead of print
Source: Clinical Chemistry and Laboratory Medicine - Category: Laboratory Medicine Source Type: research
Antiphospholipid Syndrome (APS) important in vascular medicine as well as obstetrics. In obstetrics, it is important because it can cause fetal loss, intrauterine growth retardation and severe preeclampsia. In vascular medicine it is important because it can cause thrombotic events which could be arterial, venous or microvascular [1]. It can also be accompanied by moderate thrombocytopenia [2]. Thrombotic events involving multiple organs may be termed catastrophic Antiphospholipid Syndrome [3]. APS is an autoimmune disease with antibodies directed against beta2 glycoprotein I. This leads to suppression of tissue fact...
Source: Cardiophile MD - Category: Cardiology Authors: Tags: General Cardiology anti beta2 glycoprotein I antibodies anti cardiolipin antibodies lupus anticoagulant Source Type: blogs
It is needless to say that heart disease in pregnancy is a challenge for the obstetrician and the cardiologist. Hemodynamic changes in pregnancy and labour can adversely affect many of the significant cardiac lesions. Increase in blood volume and heart rate are the important factors during pregnancy. In general stenotic lesions and pulmonary hypertension are poorly tolerated, while regurgitant lesions are better tolerated. Specific risks like aortic dissection and rupture are there for coarctation of aorta. Several risk stratification schemes have been developed for assessing the risk of pregnancy with heart disease over ...
Source: Cardiophile MD - Category: Cardiology Authors: Tags: General Cardiology CARPREG II risk scoring CARPREG risk stratification mWHO classification ZAHARA risk score Source Type: blogs
Source: NanoFocus - Category: Nanotechnology Authors: Source Type: research
CONCLUSION: Several drugs were prescribed even though they were not recommended, and few patients were treated optimally. It seems to be necessary to develop a pragmatic tool to help GPs and cardiologists in optimizing treatment.
. PMID: 29792395 [PubMed - as supplied by publisher]
Source: International Journal of Clinical Pharmacology and Therapeutics - Category: Drugs & Pharmacology Tags: Int J Clin Pharmacol Ther Source Type: research
ARTHRITIS symptoms consist of joint stiffness, pain and swelling, among others. Types of the condition include rheumatoid arthritis, psoriatic arthritis and osteoarthritis. You ’re more likely to develop the condition if you’re older, overweight or have a previous injury. This joint exercise can help treat the symptoms.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
The TWiVerati follow up on the Ebola virus outbreak, virulence of Ebola-Makona, and reveal how a parasitoid is revealed to hyperparasitoids, and binding of influenza virus to a calcium ion channel to mediate influenza virus entry. Hosts: Vincent Racaniello, Alan Dove, and Kathy Spindler Become a patron of TWiV! Links for this episode ASM Microbe 2018 Support Viruses &Cells Gordon Conference Faculty positions at Icahn School of Medicine International dsRNA Virus Symposium Tracing Ebola virus contacts(CIDRAP) WHO FAQ Ebola virus vaccine(WHO) Nipah virusoutbreak (CIDRAP) Revealingparasitoid t...
Source: This Week in Virology - MP3 Edition - Category: Virology Authors: Source Type: podcasts
This study aimed to investigate trends in mastectomy and breast reconstruction over the past 10 years and to evaluate the impact of NHIS coverage on breast reconstruction. METHODS: Nationwide data regarding mastectomy and breast reconstruction were collected from the Korean Breast Cancer Society registry database. Multiple variables were analyzed in the records of patients who underwent breast reconstruction from January 2005 to March 2017 at a single institution. RESULTS: At Seoul National University Hospital, the total number of reconstruction cases increased 13-fold from 2005 to 2016. The proportion of immediate...
Source: Archives of Plastic Surgery - Category: Cosmetic Surgery Tags: Arch Plast Surg Source Type: research
More News: Age-Related Macular Degeneration (AMD) | Alcoholism | ALS | Alternative and Complementary Therapies | Alzheimer's | Amnesia | Autoimmune Disease | Biochemistry | Biomedical Science | Biotechnology | Blindness | Brain | Brain Cancers | Budgets | Cancer | Cancer & Oncology | Cancer Vaccines | Cardiology | Cardiovascular | Carisoprodol | Child Development | Children | Cholesterol | Clinical Trials | Contracts | Cytomegalovirus | Dementia | Environmental Health | Epithelial Cancer | Expenditures | Eyes | Funding | Fundraising | Gastroschisis Repair | Genetics | Grants | Hand, Foot and Mouth | Health | Health Medicine & Bioethics Commentators | Heart | Heart Disease | Heart Failure | Heart Transplant | Hormones | Infectious Diseases | Internet | Investigational New Drugs | Kidney Transplant | Kidney Transplantation | Laboratory Medicine | Learning | Legislation | Men | Mitochondria | Molecular Biology | Nanotechnology | Neurology | Neuroscience | Nicotine | Nutrition | Obesity | Opthalmology | Oral Cancer | Parkinson's Disease | Pathology | PET Scan | Pharmaceuticals | Physiology | Reproduction Medicine | Research | Schizophrenia | Science | Sjogren's Syndrome | Smokers | Soma | Sports Medicine | Stem Cell Therapy | Stem Cells | Stroke | Study | Toxicology | Transplant Surgery | Transplants | Universities & Medical Training | Urology & Nephrology | Vaccines | Veterinary Vaccinations | Women