Fight Aging! Newsletter, August 29th 2016
This study demonstrates that TNTs play a significant part in the intercellular transfer of α-synuclein fibrils and reveals the specific role of lysosomes in this process. This represents a major breakthrough in understanding the mechanisms underlying the progression of synucleinopathies. These compelling findings, together with previous reports from the same team, point to the general role of TNTs in the propagation of prion-like proteins in neurodegenerative diseases and identify TNTs as a new therapeutic target to combat the progression of these incurable diseases. Shorter Period of Rapamycin Treatment in Mice Produces Greater Slowing of Aging https://www.fightaging.org/archives/2016/08/shorter-period-of-rapamycin-treatment-in-mice-produces-greater-slowing-of-aging/ Rapamycin, an immunosuppressant and MTOR inhibitor, is known to slow aging in mice - though it has been debated whether this extension of life span is actually a slowing of aging versus a lower rate of cancer. Researchers here try a variety of different treatment regimens and find that a comparatively short period of rapamycin treatment in mouse middle age produces better effects than the longer term dosage that has been standard in studies. The publicity materials emphasize the high points and the outliers in the mouse data; I'd recommend reading the paper for a more responsible and overall view of the outcomes. Even with improved results and possibly a new longevity record for thi...
This health promotion project is a 12-week program for adults in a rural West Virginia community with a body mass index (BMI) of 25 or greater. The goals of this project were to facilitate learning through modules focusing on activity and nutrition, increase knowledge of healthy activity and nutrition, and improve weight and BMI. Each 12-week session provided evidenced-based information regarding obesity, physical activity, and nutrition. Participants completed pre- and postprogram and 1-month follow-up survey/questionnaire. Results were compared for changes in activity, nutrition, and BMI. The program resulted in positive...
DISCUSSION: According to data from national population surveys, since 2004, cannabis use was stable or decreased among youth, and rose among adults. Results highlight the importance of consistent monitoring of use in the pre-and post-legalization periods. PMID: 29465739 [PubMed - in process]
"We're not college kids who invented a hangover cure."
Authors: Madueno MC, Dalbo VJ, Guy JH, Giamarelos KE, Spiteri T, Scanlan AT Abstract PURPOSE: To investigate the physiological and performance effects of active and passive recovery between repeated-change-of-direction (RCOD) sprints. METHODS: Eight semi-professional basketball players (age: 19.9 ± 1.5 yr; stature: 183.0 ± 9.6 cm; body mass: 77.7 ± 16.9 kg; body fat: 11.8 ± 6.3%; VO2peak: 46.1 ± 7.6 mL·kg-1·min-1) completed 12 x 20-m RCOD sprints (Agility 5-0-5 Tests) interspersed with 20 s of active (50% maximal aerobic speed) or passive recovery in a randomized...
Erin Silverman, 35, of Potomac, Maryland, became a surrogate after her sister, Randi Fishman, 34, was diagnosed with breast cancer. Erin gave birth to her sister's baby in December.
A leader in IBM ’ s development of a speech-recognition system, she relied on her laptop to communicate after Lou Gehrig ’ s disease left her paralyzed.
Authors: Doğan A Abstract After progressive improvement in embryonic stem (ES) cell field, several studies have been conducted to explore the usage of ES cells in regenerative medicine. Unlimited self renewal and pluripoteny properties, combined with encouraging preclinical trials, remark that ES cell technology might be promising for clinical practice. ES cells, which can form three germ layers in vitro, are potential candidates to study development at the cellular and molecular level. Understanding the cell fate decision and differentiation processes during development might enable generating functional progenit...
The agency adds a new warning about the increased risk for death in patients with heart disease prescribed the antibiotic clarithromycin and recommends considering an alternative when possible.News Alerts
Conclusions: Stent placement for treatment of carotid webs can be performed safely. Further studies are needed to confirm our findings.Intervent Neurol 2018;7:233 –240
Conclusion: CKD is frequent at PAH diagnosis and is independently associated with increased mortality. Right heart failure may induce renal hypoperfusion and congestion, and is associated with eGFR decrease.Am J Nephrol 2018;47:134 –143
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