Fight Aging! Newsletter, August 29th 2016

This study demonstrates that TNTs play a significant part in the intercellular transfer of α-synuclein fibrils and reveals the specific role of lysosomes in this process. This represents a major breakthrough in understanding the mechanisms underlying the progression of synucleinopathies. These compelling findings, together with previous reports from the same team, point to the general role of TNTs in the propagation of prion-like proteins in neurodegenerative diseases and identify TNTs as a new therapeutic target to combat the progression of these incurable diseases. Shorter Period of Rapamycin Treatment in Mice Produces Greater Slowing of Aging https://www.fightaging.org/archives/2016/08/shorter-period-of-rapamycin-treatment-in-mice-produces-greater-slowing-of-aging/ Rapamycin, an immunosuppressant and MTOR inhibitor, is known to slow aging in mice - though it has been debated whether this extension of life span is actually a slowing of aging versus a lower rate of cancer. Researchers here try a variety of different treatment regimens and find that a comparatively short period of rapamycin treatment in mouse middle age produces better effects than the longer term dosage that has been standard in studies. The publicity materials emphasize the high points and the outliers in the mouse data; I'd recommend reading the paper for a more responsible and overall view of the outcomes. Even with improved results and possibly a new longevity record for this mo...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs