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Specialty: Cytology
Therapy: Radiation Therapy
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Total 334 results found since Jan 2013.
The disappearance of gastric metastasis and liver metastasis in non-small cell lung adenocarcinoma is due to osimertinib
CONCLUSIONS: This is the first report to our knowledge of a patient who presented with gastric and hepatic metastases from lung cancer and achieved complete remission with osimertinib and local radiotherapy, with good quality of life, which also provides a basis for future clinical work and is of great significance.PMID:37695388 | DOI:10.1007/s00432-023-05386-7
Source: Cell Research - September 11, 2023 Category: Cytology Authors: Yun Wang Chao Yan Chuantao Zhang Enhao Yu Kai Wang Xiangyong Liu Jie Yu Chunyang Zhou Aijie Yang Source Type: research
Radiation-sensitive genetic prognostic model identifies individuals at risk for radiation resistance in head and neck squamous cell carcinoma
CONCLUSIONS: Our prognostic model based on a radiation-related gene signature has potential for application as a tool for risk stratification of radiation therapy for patients with HNSCC, helping to identify candidates for radiation therapy and overcome radiation resistance.PMID:37656244 | DOI:10.1007/s00432-023-05304-x
Source: Cell Research - September 1, 2023 Category: Cytology Authors: Peimeng You Shengbo Liu Qiaxuan Li Daipeng Xie Lintong Yao Chenguang Guo Zefeng Guo Ting Wang Hongrui Qiu Yangzhong Guo Junyu Li Haiyu Zhou Source Type: research
The 5-Year Disease-Free Survival of Third Generation Aromatase Inhibitor for Postmenopausal Women with HR-Positive HER2-Negative Non-Metastatic Breast Cancer
Conclusion: 5-year letrozole administration could be proposed as first-line therapy for postmenopausal women with HR-positive HER2-negative BC. A considerable subject and long-term follow-up are needed for validation.PMID:37638281 | PMC:PMC10448920 | DOI:10.18502/ijhoscr.v17i1.11713
Source: Cell Research - August 28, 2023 Category: Cytology Authors: Ria Etikasari Tri Murti Andayani Dwi Endarti Kartika Widayati Taroeno-Hariadi Source Type: research
PD-L1 expression and prognosis in definitive radiotherapy patients with neuroendocrine cervical carcinoma
CONCLUSION: In patients with mixed NECC, positive PD-L1 expression is correlated with higher 3-year PFS. Chemoradiotherapy was effective for NECCs. The LNM and stage predicted PFS. Four or more cycles of chemotherapy improve prognosis. Prophylactic EFI did not significantly improve PFS and OS.RELEVANCE FOR PATIENTS: This study is relevant to patients as it confirms that chemoradiotherapy is effective for both early and locally advanced NECC and that four or more cycles of chemotherapy improved prognosis. The regimen should be carefully evaluated to ensure that patients receive the most effective radiation therapy for the p...
Source: Cell Research - August 18, 2023 Category: Cytology Authors: Huiling Li Xiuhua Li Meichun Yang Huiyan Su Jianqiu Zhang Chunmiao Hu Yingming Sun Dan Hu Li Chen Source Type: research
Safety and Tolerability of Low-Dose Radiation and Stereotactic Body Radiotherapy + Sintilimab for Treatment-Naive Stage IV PD-L1+ Non-Small-Cell Lung Cancer Patients
CONCLUSIONS: The findings indicate that the novel SBRT + LDRT + sintilimab therapy is safe and promising in patients with PD-L1-positive, driver gene-negative primary metastatic NSCLC.PMID:37581611 | DOI:10.1158/1078-0432.CCR-23-0315
Source: Cell Research - August 15, 2023 Category: Cytology Authors: Xiaojuan Zhou Laiyan Zhou Zhuoran Yao Meijuan Huang Youling Gong Bingwen Zou Jiang Zhu Yongmei Liu Feng Peng Yan Zhang Min Yu Yanying Li Feifei Na Yijun Wu Kai Kang Weigang Xiu Xuanwei Zhang Lin Zhou Yong Xu Jin Wang Yan Wang Xue Yang Yuanjun Wu Rui Li Yu Source Type: research
Tumor-targeted non-ablative radiation promotes solid tumor CAR T-cell therapy efficacy
In this study, we investigate the influence of tumor-targeted radiation on chimeric antigen receptor (CAR) T-cell therapy tumor infiltration, accumulation, and efficacy in clinically relevant models of pleural mesothelioma and non-small cell lung cancers. We use a non-ablative dose of tumor-targeted radiation prior to systemic administration of mesothelin-targeted CAR T cells to assess infiltration, proliferation, anti-tumor efficacy, and functional persistence of CAR T cells at primary and distant sites of tumor. A tumor-targeted, non-ablative dose of radiation promotes early and high infiltration, proliferation, and func...
Source: Cell Research - August 4, 2023 Category: Cytology Authors: Hue Tu Quach Matthew S Skovgard Jonathan Villena-Vargas Rebecca Y Bellis Navin K Chintala Alfredo Amador-Molina Yang Bai Srijita Banerjee Jasmeen Saini Yuquan Xiong William-Ray Vista Alexander J Byun Andreas De Biasi Masha Zeltsman Marissa Mayor Aurore Mo Source Type: research
A pilot study omitting radiation in the treatment of children with newly diagnosed Wnt-activated medulloblastoma
CONCLUSIONS: Radiation therapy is required to effectively treat children with WNT-altered medulloblastoma.PMID:37498309 | DOI:10.1158/1078-0432.CCR-23-0348
Source: Cell Research - July 27, 2023 Category: Cytology Authors: Kenneth J Cohen Vasu Munjapara Dolly Aguilera Robert C Castellino Stacie L Stapleton Daniel Landi David M Ashley Fausto J Rodriguez Cynthia Hawkins Edward Yang Wendy London Susan Chi Pratiti Bandopadhayay Source Type: research
Early clinical trial unit tumor board: a real-world experience in a national cancer network
CONCLUSION: The ECTU Tumor Board is a feasible and successful network, highlighting the force of virtual patient discussions for improving patient care as well as trial recruitment in advanced diseases. It can provide further treatment options after local MTB presentation, aiming to close the gap to access clinical trials.PMID:37490102 | DOI:10.1007/s00432-023-05196-x
Source: Cell Research - July 25, 2023 Category: Cytology Authors: L Weiss K Dorman M Boukovala F Schwinghammer P Jordan T Fey K Hasselmann M Subklewe V B ücklein R Bargou M Goebeler C Sayehli S Spoerl F L üke D Heudobler R Claus I von Luettichau S Lorenzen S Lange C B Westphalen M von Bergwelt-Baildon V Heinemann C Gi Source Type: research
New immunotherapeutic approaches for cancer treatment
Pathol Res Pract. 2023 Jun 19;248:154632. doi: 10.1016/j.prp.2023.154632. Online ahead of print.ABSTRACTNeoplasms are a worldwide recognized non-contagious disease which has the most mortality rate after cardiovascular diseases. For decades, there has been a vast amount of study on treatment methods of cancer which has led to conventional therapies such as chemotherapy, radiation therapy, surgery and so on. Clinicians and researchers believed that there is an urgent need, considering the high rate of incidence and prevalence, for an alternative treatment option which is more efficacious and has less adverse effects than th...
Source: Cell Research - July 22, 2023 Category: Cytology Authors: Amin Kamrani Ramin Hosseinzadeh Navid Shomali Javad Ahmadian Heris Parviz Shahabi Reza Mohammadinasab Shahram Sadeghvand Kazem Ghahremanzadeh Mohammadreza Sadeghi Morteza Akbari Source Type: research
Radiation therapy-induced neurocognitive impairment is driven by heightened apoptotic priming in early life and prevented by blocking BAX
Cancer Res. 2023 Jul 20:CAN-22-1337. doi: 10.1158/0008-5472.CAN-22-1337. Online ahead of print.ABSTRACTAlthough external beam radiation therapy (xRT) is commonly used to treat central nervous system (CNS) tumors in patients of all ages, young children treated with xRT frequently experience life-altering and dose-limiting neurocognitive impairment (NI) while adults do not. The lack of understanding of mechanisms responsible for these differences has impeded the development of neuroprotective treatments. Using a newly developed mouse model of xRT-induced NI, we found that neurocognitive function is impaired by ionizing radia...
Source: Cell Research - July 20, 2023 Category: Cytology Authors: Rumani Singh Stacey Yu Marwa Osman Zintis Inde Cameron Fraser Abigail H Cleveland Nicole Almanzar Chuan Bian Lim Gaurav N Joshi Johan Spetz Xingping Qin Sneh M Toprani Zachary Nagel Matthew C Hocking Robert A Cormack Torunn I Yock Jeffrey W Miller Zhi-Min Source Type: research
X-ray and MR Contrast Bearing Nanoparticles Enhance the Therapeutic Response of Image-Guided Radiation Therapy for Oral Cancer
CONCLUSIONS: Theranostic nanoparticles enable preprocedure radiotherapy planning, as well as enhance radiation treatment efficacy for head and neck tumors.PMID:37469184 | DOI:10.1177/15330338231189593
Source: Cell Research - July 20, 2023 Category: Cytology Authors: Gayatri Sharma Mir Hadi Razeghi Kondelaji Guru P Sharma Christopher Hansen Abdul K Parchur Shayan Shafiee Jaidip M Jagtap Brian Fish Carmen Bergom Eric Paulson William A Hall Heather A Himburg Amit Joshi Source Type: research
Dual impact of radiation therapy on tumor-targeting immune responses
Int Rev Cell Mol Biol. 2023;378:xiii-xxiv. doi: 10.1016/S1937-6448(23)00114-4.NO ABSTRACTPMID:37438022 | DOI:10.1016/S1937-6448(23)00114-4
Source: International Review of Cell and Molecular Biology - July 12, 2023 Category: Cytology Authors: C éline Mirjolet J érémy Baude Lorenzo Galluzzi Source Type: research
The role of dendritic cells in radiation-induced immune responses
Int Rev Cell Mol Biol. 2023;378:61-104. doi: 10.1016/bs.ircmb.2023.02.002. Epub 2023 Mar 24.ABSTRACTDendritic cells perform critical functions in bridging innate and adaptive immunity. Their ability to sense adjuvant signals in their environment, migrate on maturation, and cross-present cell-associated antigens enables these cells to carry antigen from tissue sites to lymph nodes, and thereby prime naïve T cells that cannot enter tissues. Despite being an infrequent cell type in tumors, we discuss how dendritic cells impact the immune environment of tumors and their response to cancer therapies. We review how radiation th...
Source: International Review of Cell and Molecular Biology - July 12, 2023 Category: Cytology Authors: Aanchal Preet Kaur Alejandro Alice Marka R Crittenden Michael J Gough Source Type: research
