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Cerebrovascular Disease, Cardiovascular Disease, and Chronic Kidney Disease: Interplays and Influences
Curr Neurol Neurosci Rep. 2022 Oct 1. doi: 10.1007/s11910-022-01230-6. Online ahead of print.ABSTRACTPURPOSE OF REVIEW: We reviewed reasons for the high cardiovascular risk (CVD) of patients with chronic kidney disease (CKD), and explored alternatives to treatment of traditional risk factors to reduce CVD in CKD.RECENT FINDINGS: Besides traditional risk factors, patients with CKD are exposed to uremic toxins of two kinds: systemically derived toxins include asymmetric dimethylarginine (ADMA), total homocysteine (tHcy), thiocyanate, tumor necrosis factor alpha, and interleukin 6. Gut-derived uremic toxins (GDUT), products o...
Source: Atherosclerosis - October 1, 2022 Category: Cardiology Authors: J David Spence Bradley L Urquhart Source Type: research

Vitamin B12 and chronic kidney disease
Vitam Horm. 2022;119:325-353. doi: 10.1016/bs.vh.2022.01.011. Epub 2022 Feb 25.ABSTRACTChronic Kidney Disease (CKD) is an emerging public health issue with a fast-growing global prevalence. Impairment in vitamin B12 metabolism is considered a nontraditional risk factor of poor outcomes associated with CKD, and there is greater interest from the scientific community than ever before to explore the role and influence of vitamin B12 in CKD. Homocysteine metabolism forms an important component of the vitamin B12 metabolic pathway. Hyperhomocysteinemia is frequently observed in CKD and End-Stage Kidney Disease (ESKD), but its r...
Source: Vitamins and Hormones - March 26, 2022 Category: Endocrinology Authors: Henry H L Wu Angela Yee-Moon Wang Source Type: research

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