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Therapy: Cancer Therapy
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Total 170 results found since Jan 2013.
Allosteric switch for electrochemical aptasensor toward heavy metals pollution of Lentinus edodes sensitized with porphyrinic metal-organic frameworks
We present an appropriate electrochemical aptasensor for Ag + assay based on biomimetic catalysis of porphyrin-encapsulated MOF (PorMOF) and allosteric switch of C-rich DNA. Thanks to the excellent biocompatibility, PorMOFs as nanozyme are used to design signal probes by loading duplex-like DNA scaffold. Owing to the specific recognition of Ag+ toward cytosine (C) base-rich DNA, PorMOF at the distal end was close to the underlying electrode via C-Ag+-C formation, leading to an enhanced current of catalytic hydroxylamine oxidation for signal generation. Using the positive correlation between current response and Ag+ level, ...
Source: Analytica Chimica Acta - September 14, 2023 Category: Chemistry Authors: Xiaowei Huang Chenyong Huang Lili Zhou Guangyue Hou Jinyuan Sun Xinai Zhang Xiaobo Zou Source Type: research
The Effects of Environmental Aryl Hydrocarbon Receptor Ligands on Signaling and Cell Metabolism in Cancer
Biochem Pharmacol. 2023 Aug 29:115771. doi: 10.1016/j.bcp.2023.115771. Online ahead of print.ABSTRACTDioxin and dioxin-like compounds are chlorinated organic pollutants formed during the manufacturing of other chemicals. Dioxins are ligands of the aryl hydrocarbon receptor (AHR), that induce AHR-mediated biochemical and toxic responses and are persistent in the environment. 2,3,7,8- tetrachlorodibenzo para dioxin (TCDD) is the prototypical AHR ligand and its effects represent dioxins. TCDD induces toxicity, immunosuppression and is a suspected tumor promoter. The role of TCDD in cancer however is debated and context-depend...
Source: Biochemical Pharmacology - August 31, 2023 Category: Drugs & Pharmacology Authors: Sean A Piwarski Travis B Salisbury Source Type: research
Multifunctional nanoadjuvant-driven microenvironment modulation for enhanced photothermal immunotherapy in breast cancer
In this study, we developed a multifunctional nanoadjuvant, termed GITFe/Z-HA, by modified a metal-organic backbone Fe/ZIF-8 with hyaluronic acid (HA) targeting. The nanocarriers were loaded with glucose oxidase (Gox), neoindocyanine green (IR820) and tilazamine (TPZ). This design aimed to achieve a cascade reaction within tumor cells, mediated by Gox, Fe3+, and IR820, which consumes intrinsic glucose and oxygen, leading to an elevated production of reactive oxygen species (ROS). This cascade reaction creates a hypoxic environment conducive for TPZ to exert its therapeutic action. Consequently, the combination of photother...
Source: Cancer Control - August 27, 2023 Category: Cancer & Oncology Authors: Ge Li Jingbo Zhang Shixin Zhang Lesheng Teng Fengying Sun Source Type: research
Water-Soluble Alkali Lignin as a Natural Radical Scavenger and Anticancer Alternative
Int J Mol Sci. 2023 Aug 11;24(16):12705. doi: 10.3390/ijms241612705.ABSTRACTSeveral phytochemicals, which display antioxidant activity and inhibit cancer cell phenotypes, could be used for cancer treatment and prevention. Lignin, as a part of plant biomass, is the second most abundant natural biopolymer worldwide, and represents approximately 30% of the total organic carbon content of the biosphere. Historically, lignin-based products have been viewed as waste materials of limited industrial usefulness, but modern technologies highlight the applicability of lignin in a variety of industrial branches, including biomedicine....
Source: Cancer Control - August 26, 2023 Category: Cancer & Oncology Authors: Donika Ivanova Galina Nikolova Yanka Karamalakova Severina Semkova Vania Marutsova Zvezdelina Yaneva Source Type: research
Polysaccharide-based tumor microenvironment-responsive drug delivery systems for cancer therapy
J Control Release. 2023 Aug 12:S0168-3659(23)00517-5. doi: 10.1016/j.jconrel.2023.08.019. Online ahead of print.ABSTRACTThe biochemical indicators of tumor microenvironment (TME) that are different from normal tissues provide the possibility for constructing intelligent drug delivery systems (DDSs). Polysaccharides with good biocompatibility, biodegradability, and unique biological properties are ideal materials for constructing DDSs. Nanogels, micelles, organic-inorganic nanocomposites, hydrogels, and microneedles (MNs) are common polysaccharide-based DDSs. Polysaccharide-based DDSs enable precise control of drug delivery...
Source: Cancer Control - August 14, 2023 Category: Cancer & Oncology Authors: Qimeng Wu Yang Hu Bing Yu Hao Hu Fu-Jian Xu Source Type: research
Photoresponsive Inorganic Nanomaterials in Oncology
Technol Cancer Res Treat. 2023 Jan-Dec;22:15330338231192850. doi: 10.1177/15330338231192850.ABSTRACTThe diagnosis and treatment of cancer are continuously evolving in search of more efficient, safe, and personalized approaches. Therapies based on nanoparticles or physical stimuli-responsive substances have shown great potential to overcome the inherent shortcomings of conventional cancer therapies. In fact, nanoparticles may increase the half-life of chemotherapeutic agents or promote the targeting in cancer tissues while physical stimuli-responsive substances are more effective and safer with respect to traditional chemot...
Source: Technology in Cancer Research and Treatment - August 8, 2023 Category: Cancer & Oncology Authors: Francesco Barbero Shagufta Gul Guido Perrone Ivana Fenoglio Source Type: research
Heterogeneous-Driven Glutathione Oxidation: Defining the Catalytic Role of Chalcopyrite Nanoparticles
J Phys Chem C Nanomater Interfaces. 2023 Jul 12;127(29):14146-14154. doi: 10.1021/acs.jpcc.3c00987. eCollection 2023 Jul 27.ABSTRACTTransition-metal nanocatalysis represents a novel alternative currently experiencing flourishing progress to tackle the tumor microenvironment (TME) in cancer therapy. These nanomaterials aim at attacking tumor cells using the intrinsic selectivity of inorganic catalysts. In addition, special attention to tune and control the release of these transition metals is also required. Understanding the chemical reactions behind the catalytic action of the transition-metal nanocatalysts and preventing...
Source: Cancer Control - August 2, 2023 Category: Cancer & Oncology Authors: Leticia Sanchez-Uriel Javier Bonet-Aleta Alfonso Ibarra Jose L Hueso Source Type: research
