• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

Transmembrane Stem Factor Nanodiscs Enhanced Revascularization in a Hind Limb Ischemia Model in Diabetic, Hyperlipidemic Rabbits
Res Sq. 2023 Jun 16:rs.3.rs-2997323. doi: 10.21203/rs.3.rs-2997323/v1. Preprint.ABSTRACTTherapies to revascularize ischemic tissue have long been a goal for the treatment of vascular disease and other disorders. Therapies using stem cell factor (SCF), also known as a c-Kit ligand, had great promise for treating ischemia for myocardial infarct and stroke, however clinical development for SCF was stopped due to toxic side effects including mast cell activation in patients. We recently developed a novel therapy using a transmembrane form of SCF (tmSCF) delivered in lipid nanodiscs. In previous studies, we demonstrated tmSCF n...
Source: Cell Research - July 3, 2023 Category: Cytology Authors: Eri Takematsu Miles Massidda Gretchen Howe Julia Goldman Patricia Felli Lei Mei Gregory Callahan Andrew Sligar Richard Smalling Aaron Baker Source Type: research

A Novel Rat Model of Embolic Cerebral Ischemia Using a Cell-Implantable Radiopaque Hydrogel Microfiber
We present a novel rat model of focal infarct restricted to the middle cerebral artery territory using a radiopaque hydrogel microfiber positioned under fluoroscopic guidance. By comparing the use of stem cell-containing versus non-containing fibers in this stroke model, it would be possible to determine the efficacy of "pure" cell transplantation in treating stroke.PMID:36867349 | DOI:10.1007/s12975-023-01144-6
Source: Cell Research - March 3, 2023 Category: Cytology Authors: Teppei Komatsu Hiroki Ohta Naoki Takakura Junichi Hata Tomomichi Kitagawa Yuta Kurashina Hiroaki Onoe Hirotaka James Okano Yasuyuki Iguchi Source Type: research

Comprehensive Profiling of Secreted Factors in the Cerebrospinal Fluid of Moyamoya Disease Patients
Transl Stroke Res. 2023 Feb 6. doi: 10.1007/s12975-023-01135-7. Online ahead of print.ABSTRACTMoyamoya disease (MMD) is characterized by progressive occlusion of the intracranial internal carotid arteries, leading to ischemic and hemorrhagic events. Significant clinical differences exist between ischemic and hemorrhagic MMD. To understand the molecular profiles in the cerebrospinal fluid (CSF) of MMD patients, we investigated 62 secreted factors in both MMD subtypes (ischemic and hemorrhagic) and examined their relationship with preoperative perfusion status, the extent of postoperative angiographic revascularization, and ...
Source: Cell Research - February 6, 2023 Category: Cytology Authors: Kumar Abhinav Alex G Lee Arjun V Pendharkar Mark Bigder Anthony Bet Yael Rosenberg-Hasson Michelle Y Cheng Gary K Steinberg Source Type: research

Inhibition of the immunoproteasome LMP2 ameliorates ischemia/hypoxia-induced blood-brain barrier injury through the Wnt/ β-catenin signalling pathway
CONCLUSION: This study suggests that inhibition of the immunoproteasome LMP2 ameliorates ischemia/hypoxia-induced BBB injury, and that the molecular mechanism involves the immunoproteasome-regulated activation of the Wnt/β-catenin signalling pathway under ischemic conditions.PMID:34857032 | DOI:10.1186/s40779-021-00356-x
Source: Cell Research - December 3, 2021 Category: Cytology Authors: Xing-Yong Chen Shao-Fen Wan Nan-Nan Yao Ze-Jing Lin Yan-Guang Mao Xiao-Hua Yu Yin-Zhou Wang Source Type: research

Serum Calcium is Related to the Degree of Artery Stenosis in Acute Ischemic Stroke
Conclusion: Our results suggest that the concentration of serum calcium is higher in patients with more severe artery stenosis lesions and that the phosphatidylinositol signaling system is a key biological pathway involved in this process.Cell Physiol Biochem 2018;46:1189 –1197
Source: Cellular Physiology and Biochemistry - April 23, 2018 Category: Cytology Source Type: research