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Intraabdominal pressure, cardiac index and vascular resistance during hyperthermic intraperitoneal chemotherapy - a prospective observational study.
CONCLUSIONS: Increased intraabdominal pressure during HIPEC was comparable to pneumoperitoneum. Haemodynamic changes however were opposed with a decrease in SVRI and a compensative increase in CI. Current guidelines for anaesthetic management in patients undergoing HIPEC are mainly based on findings from laparoscopic surgery and should therefore be reconsidered critically. PMID: 25971283 [PubMed - as supplied by publisher]
Source: Minerva Anestesiologica - May 16, 2015 Category: Anesthesiology Tags: Minerva Anestesiol Source Type: research

Time course of cytokines, hemodynamic and metabolic parameters during hyperthermic intraperitoneal chemotherapy.
CONCLUSION: The most significant variations are those of IL-6 and PCT. The cytokines level parallel the hemodynamic derangements. Treatment during HIPEC should mimic the established treatment during sepsis and septic shock. PMID: 26154446 [PubMed - as supplied by publisher]
Source: Minerva Anestesiologica - July 13, 2015 Category: Anesthesiology Tags: Minerva Anestesiol Source Type: research

Effects of neoadjuvant chemo or chemoradiotherapy for oesophageal cancer on perioperative haemodynamics: A prospective cohort study within a randomised clinical trial
CONCLUSION: Neoadjuvant chemoradiotherapy for oesophageal or gastrooesophageal junction cancer seems to induce only a marginal negative effect on cardiac function compared with neoadjuvant chemotherapy. This difference did not remain when patients’ haemodynamics were challenged by surgery. TRIAL REGISTRATION: ClinicalTrials.gov identifier: NCT01362127.
Source: European Journal of Anaesthesiology - August 3, 2016 Category: Anesthesiology Tags: Cardiovascular physiology Source Type: research

Goal-directed therapy with bolus albumin 5% is not superior to bolus ringer acetate in maintaining systemic and mesenteric oxygen delivery in major upper abdominal surgery: A randomised controlled trial
CONCLUSION Bolus human albumin 5% was not superior to bolus ringer acetate in maintaining systemic or mesenteric oxygen delivery in elective major upper gastrointestinal cancer surgery, despite the administration of larger volumes of trial fluid in the ringer acetate group. No significant difference was seen in fluid-related complications or LOS. TRIAL REGISTRATION https://eudract.ema.europa.eu/ Identifier: 2013-002217-36.
Source: European Journal of Anaesthesiology - May 11, 2020 Category: Anesthesiology Tags: Haemodynamics Source Type: research