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Selective serotonin reuptake inhibitors (SSRIs) for stroke recovery.
CONCLUSIONS SSRIs appeared to improve dependence, disability, neurological impairment, anxiety and depression after stroke, but there was heterogeneity between trials and methodological limitations in a substantial proportion of the trials. Large, well-designed trials are now needed to determine whether SSRIs should be given routinely to patients with stroke. PMID: 23903272 [PubMed - in process]
Source: Sao Paulo Medical Journal - August 3, 2013 Category: Journals (General) Authors: Mead GE, Hsieh CF, Lee R, Kutlubaev MA, Claxton A, Hankey GJ, Hacklett ML Tags: Sao Paulo Med J Source Type: research

Very early versus delayed mobilisation after stroke.
CONCLUSIONS: VEM, which usually involved first mobilisation within 24 hours of stroke onset, did not increase the number of people who survived or made a good recovery after their stroke. VEM may have reduced the length of stay in hospital by about one day, but this was based on low-quality evidence. Based on the potential hazards reported in the single largest RCT, the sensitivity analysis of trials commencing mobilisation within 24 hours, and the NMA, there was concern that VEM commencing within 24 hours may carry an increased risk, at least in some people with stroke. Given the uncertainty around these effect estimates,...
Source: Cochrane Database of Systematic Reviews - October 16, 2018 Category: General Medicine Authors: Langhorne P, Collier JM, Bate PJ, Thuy MN, Bernhardt J Tags: Cochrane Database Syst Rev Source Type: research

Acupuncture treatment for ischaemic stroke in young adults: protocol for a randomised, sham-controlled clinical trial
Introduction Stroke in young adults is not uncommon. Although the overall incidence of stroke has been recently declining, the incidence of stroke in young adults is increasing. Traditional vascular risk factors are the main cause of young ischaemic stroke. Acupuncture has been shown to benefit stroke rehabilitation and ameliorate the risk factors for stroke. The aims of this study were to determine whether acupuncture treatment will be effective in improving the activities of daily living (ADL), motor function and quality of life (QOL) in patients of young ischaemic stroke, and in preventing stroke recurrence by controlli...
Source: BMJ Open - January 6, 2016 Category: Journals (General) Authors: Chen, L., Fang, J., Jin, X., Keeler, C. L., Gao, H., Fang, Z., Chen, Q. Tags: Open access, Complementary medicine, Neurology, Rehabilitation medicine Protocol Source Type: research

Electromechanical-assisted training for walking after stroke.
CONCLUSIONS: People who receive electromechanical-assisted gait training in combination with physiotherapy after stroke are more likely to achieve independent walking than people who receive gait training without these devices. We concluded that eight patients need to be treated to prevent one dependency in walking. Specifically, people in the first three months after stroke and those who are not able to walk seem to benefit most from this type of intervention. The role of the type of device is still not clear. Further research should consist of large definitive pragmatic phase 3 trials undertaken to address specific quest...
Source: Cochrane Database of Systematic Reviews - October 22, 2020 Category: General Medicine Authors: Mehrholz J, Thomas S, Kugler J, Pohl M, Elsner B Tags: Cochrane Database Syst Rev Source Type: research

Puerarin for ischaemic stroke.
CONCLUSIONS: There is not enough evidence to evaluate the effect of puerarin on survival or dependency in people with ischaemic stroke. High quality and large-scale RCTs with long-term follow-up are needed to assess its efficacy. PMID: 26891451 [PubMed - as supplied by publisher]
Source: Cochrane Database of Systematic Reviews - February 18, 2016 Category: Journals (General) Authors: Liu B, Tan Y, Wang D, Liu M Tags: Cochrane Database Syst Rev Source Type: research

Risk of epilepsy in stroke patients receiving acupuncture treatment: a nationwide retrospective matched-cohort study
Conclusions Stroke patients who received acupuncture treatment had a reduced risk of epilepsy compared with those not receiving acupuncture treatment. However, the protective effects associated with acupuncture treatment require further validation in prospective cohort studies.
Source: BMJ Open - July 12, 2016 Category: Journals (General) Authors: Weng, S.-W., Liao, C.-C., Yeh, C.-C., Chen, T.-L., Lane, H.-L., Lin, J.-G., Shih, C.-C. Tags: Open access, Complementary medicine, Epidemiology, Health services research, Neurology, Public health Source Type: research

Acupuncture for acute stroke.
CONCLUSIONS: This updated review indicates that apparently improved outcomes with acupuncture in acute stroke are confounded by the risk of bias related to use of open controls. Adverse events related to acupuncture were reported to be minor and usually did not result in stopping treatment. Future studies are needed to confirm or refute any effects of acupuncture in acute stroke. Trials should clearly report the method of randomization, concealment of allocation, and whether blinding of participants, personnel, and outcome assessors was achieved, while paying close attention to the effects of acupuncture on long-term funct...
Source: Cochrane Database of Systematic Reviews - March 30, 2018 Category: General Medicine Authors: Xu M, Li D, Zhang S Tags: Cochrane Database Syst Rev Source Type: research

Repetitive peripheral magnetic stimulation for impairment and disability in people after stroke.
CONCLUSIONS: Available trials provided insufficient evidence to permit any conclusions about routine use of rPMS for people after stroke. Additional trials with large sample sizes are needed to provide robust evidence for rPMS after stroke. PMID: 31784991 [PubMed - in process]
Source: Cochrane Database of Systematic Reviews - November 29, 2019 Category: General Medicine Authors: Sakai K, Yasufuku Y, Kamo T, Ota E, Momosaki R Tags: Cochrane Database Syst Rev Source Type: research

Repetitive peripheral magnetic stimulation for activities of daily living and functional ability in people after stroke.
CONCLUSIONS: Available trials provided inadequate evidence to permit any conclusions about routine use of rPMS for people after stroke. Additional trials with large sample sizes are needed to determine an appropriate rPMS protocol as well as long-term effects. We identified three ongoing trials and will include these trials in the next review update. PMID: 28644548 [PubMed - as supplied by publisher]
Source: Cochrane Database of Systematic Reviews - June 23, 2017 Category: General Medicine Authors: Momosaki R, Yamada N, Ota E, Abo M Tags: Cochrane Database Syst Rev Source Type: research

Interventions for treating urinary incontinence after stroke in adults.
CONCLUSIONS: There is insufficient evidence to guide continence care of adults in the rehabilitative phase after stroke. As few trials tested the same intervention, conclusions are drawn from few, usually small, trials. CIs were wide, making it difficult to ascertain if there were clinically important differences. Only four trials had adequate allocation concealment and many were limited by poor reporting, making it impossible to judge the extent to which they were prone to bias. More appropriately powered, multicentre trials of interventions are required to provide robust evidence for interventions to improve urinary inco...
Source: Cochrane Database of Systematic Reviews - February 1, 2019 Category: General Medicine Authors: Thomas LH, Coupe J, Cross LD, Tan AL, Watkins CL Tags: Cochrane Database Syst Rev Source Type: research

Repetitive peripheral magnetic stimulation for impairment and disability in people after stroke
CONCLUSIONS: There is insufficient evidence to permit the drawing of any conclusions about routine use of rPMS for people after stroke. Additional trials with large sample sizes are needed to provide robust evidence for rPMS after stroke.PMID:36169558 | DOI:10.1002/14651858.CD011968.pub4
Source: Cochrane Database of Systematic Reviews - September 28, 2022 Category: General Medicine Authors: Tomohiko Kamo Yoshitaka Wada Masatsugu Okamura Kotomi Sakai Ryo Momosaki Shunsuke Taito Source Type: research

Interventions for sexual dysfunction following stroke.
CONCLUSIONS: Use of sertraline to treat premature ejaculation needs to be tested in further RCTs. The lack of benefit with structured sexual rehabilitation and pelvic floor physiotherapy should not be interpreted as proof of ineffectiveness. Well-designed, randomised, double-blinded, placebo-controlled trials of long-term duration are needed to determine the effectiveness of various types of interventions for sexual dysfunction. It should be noted, however, that it may not be possible to double-blind trials of complex interventions. PMID: 32356377 [PubMed - in process]
Source: Cochrane Database of Systematic Reviews - April 30, 2020 Category: General Medicine Authors: Stratton H, Sansom J, Brown-Major A, Anderson P, Ng L Tags: Cochrane Database Syst Rev Source Type: research

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