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Stem cell therapies in preclinical models of stroke. Is the aged brain microenvironment refractory to cell therapy?
CONCLUSION: While the middle aged brain does not seem to impair drug and cell therapies, in a real clinical practice involving older post-stroke patients, successful regenerative therapies would have to be carried out for a much longer time. PMID: 28093317 [PubMed - as supplied by publisher]
Source: Experimental Gerontology - January 12, 2017 Category: Geriatrics Authors: Sandu RE, Balseanu A, Bogdan C, Slevin M, Petcu E, Popa-Wagner A Tags: Exp Gerontol Source Type: research

Extracellular vesicles from mesenchymal stem cells reduce microglial-mediated neuroinflammation after cortical injury in aged Rhesus monkeys
AbstractCortical injury, such as injuries after stroke or age-related ischemic events, triggers a cascade of degeneration accompanied by inflammatory responses that mediate neurological deficits. Therapeutics that modulate such neuroinflammatory responses in the aging brain have the potential to reduce neurological dysfunction and promote recovery. Extracellular vesicles (EVs) from mesenchymal stem cells (MSCs) are lipid-bound, nanoscale vesicles that can modulate inflammation and enhance recovery in rodent stroke models. We recently assessed the efficacy of intravenous infusions of MSC-EVs (24-h and 14-days post-injury) a...
Source: AGE - November 5, 2019 Category: Geriatrics Source Type: research

Transplantation of Lymphocytes Co-Cultured with Human Cord Blood-Derived Multipotent Stem Cells Attenuates Inflammasome Activity in Ischemic Stroke
Source: Clinical Interventions in Aging - December 18, 2019 Category: Geriatrics Tags: Clinical Interventions in Aging Source Type: research