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Research Progress on the Mechanisms of Central Post-Stroke Pain: A Review
Cell Mol Neurobiol. 2023 May 11. doi: 10.1007/s10571-023-01360-6. Online ahead of print.ABSTRACTCentral Post-Stroke Pain (CPSP) is a primary sequelae of stroke that can develop in the body part corresponding to the cerebrovascular lesion after stroke, most typically after ischemic stroke but also after hemorrhagic stroke. The pathogenesis of CPSP is currently unknown, and research into its mechanism is ongoing. To summarize current research on the CPSP mechanism and provide guidance for future studies. Use "central post-stroke pain," "stroke AND thalamic pain," "stroke AND neuropathic pain," "post-stroke thalamic pain" as ...
Source: Cellular and Molecular Neurobiology - May 11, 2023 Category: Cytology Authors: Yupei Cheng Bangqi Wu Jingjie Huang Yameng Chen Source Type: research

Combination of stem cell therapy and acupuncture to treat ischemic stroke: a prospective review
Stem Cell Res Ther. 2022 Mar 3;13(1):87. doi: 10.1186/s13287-022-02761-y.ABSTRACTStroke is the second leading cause globally that leads to severe disability and death. Stem cell therapy has been developed over the recent years to treat stroke and diminish the mortality and disability rate of brain injuries. Acupuncture, which can activate endogenous recovery via physical stimuli, has been applied to enhance the recovery and rehabilitation of stroke patients. Attempts have been made to combine stem cell therapy and acupuncture to treat stroke patients and have shown the promising results. This prospective review will look i...
Source: Cell Research - March 4, 2022 Category: Cytology Authors: Huidong Jia Jia He Lan Zhao Chia-Chen Hsu Xiaofeng Zhao Yuzheng Du Lin Han Zhanfeng Cui Xuemin Shi Hua Ye Source Type: research

A Narrative Review on the Non-Pharmacologic Interventions in Post-Stroke Depression
Psychol Res Behav Manag. 2022 Jul 7;15:1689-1706. doi: 10.2147/PRBM.S310207. eCollection 2022.ABSTRACTStroke is a major cause of death and disability globally. Post-stroke depression (PSD) is a major driver for poor recovery and poor quality of life with extra burden for the patient and the caregiver. We have previously shown the inflammatory basis of PSD with associated bioenergetic failure, disruption of the blood-brain barrier, cell death, and persistent maladapted inflammation, making the PSD a norm rather than the exception, highlighting the unmet need for therapeutic intervention in PSD across the recovery trajectory...
Source: Cell Research - July 14, 2022 Category: Cytology Authors: Tissa Wijeratne Carmela Sales Chanith Wijeratne Source Type: research

Electro-acupuncture treatment ameliorates intestinal inflammatory injury in cerebral ischemia-reperfusion rats via regulating the balance of Treg / γδ T cells
Brain Res. 2023 Jan 6:148233. doi: 10.1016/j.brainres.2023.148233. Online ahead of print.ABSTRACTElectro-acupuncture (EA) has an anti-inflammatory role in ischemic stroke, but whether the protective effect of EA involves the regulation of the intestine barrier and Treg/ γδ T cells is unclear. Cerebral ischemia-reperfusion (I/R) injury was induced by middle cerebral artery occlusion(MCAO) for 2 hours followed by reperfusion for 24 hours. The rats have treated with EA at the "Baihui" acupoint(GV20). Triphenyl tetrazolium chloride (TTC) staining and Longa neurologic score were performed to evaluate the outcomes after ischem...
Source: Cell Research - January 9, 2023 Category: Cytology Authors: Ya-Ling Wang Ling-Ling Meng Yong-Lin Chen Ling OuYang Bu-Fan Wu Rou Peng Sheng-Feng Lu Qing Liu Tao Zhang Xiao-Xiao Li Xin-Yue Jing Bin Xu Shu-Ping Fu Source Type: research

"Lifting Yang to Dredging Du Meridian Manipulation" acupuncture alleviates cerebral ischemia-reperfusion injury by mediating the NF- κB pathway
CONCLUSIONS: LYDD acupuncture ameliorates cerebral ischemia-reperfusion injury by inhibiting NF-κB pathway activity.PMID:37414270 | DOI:10.1016/j.brainres.2023.148477
Source: Cell Research - July 6, 2023 Category: Cytology Authors: Xiahui Zhang Lei Ma Meifang Liu Tao Zhu Zhilin Huang Youlong Xiong Ziyi Wang Jing Shi Source Type: research

Electroacupuncture Activates Neuroplasticity in the Motor Cortex and Corticospinal Tract via the mTOR Pathway in a Rat P-MCAO Model
Biomed Res Int. 2022 Nov 14;2022:3470685. doi: 10.1155/2022/3470685. eCollection 2022.ABSTRACTElectroacupuncture (EA) combines traditional Chinese medicine acupuncture theory with modern scientific technology. It is a promising therapy for the treatment of cerebrovascular diseases such as cerebral infarction. A large number of clinical studies have shown that EA promotes recovery of neurological function after cerebral infarction, however, the underlying mechanisms behind its effects remain unclear. We tested whether EA stimulation of the Zusanli (ST36) and Neiguan (PC6) acupoints activates neuroplasticity in rats with isc...
Source: Cell Research - November 28, 2022 Category: Cytology Authors: You Zhang Ya-Long Yin Zi-Yan Jin Qi-Ping Hu Xin-Gui Wu Source Type: research