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Specialty: Cytology
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Total 1150 results found since Jan 2013.
Multinuclear MRI Reveals Early Efficacy of Stem Cell Therapy in Stroke
Transl Stroke Res. 2022 Jul 28. doi: 10.1007/s12975-022-01057-w. Online ahead of print.ABSTRACTCompromised adult human mesenchymal stem cells (hMSC) can impair cell therapy efficacy and further reverse ischemic recovery. However, in vitro assays require extended passage to characterize cells, limiting rapid assessment for therapeutic potency. Multinuclear magnetic resonance imaging and spectroscopy (MRI/S) provides near real-time feedback on disease progression and tissue recovery. Applied to ischemic stroke, 23Na MRI evaluates treatment efficacy within 24 h after middle cerebral artery occlusion, showing recovery of sodiu...
Source: Cell Research - July 28, 2022 Category: Cytology Authors: Shannon Helsper Xuegang Yuan F Andrew Bagdasarian Jacob Athey Yan Li Cesario V Borlongan Samuel C Grant Source Type: research
Muse cells: ushering in a new era of stem cell-based therapy for stroke
Stem Cell Res Ther. 2022 Aug 19;13(1):421. doi: 10.1186/s13287-022-03126-1.ABSTRACTStem cell-based regenerative therapies have recently become promising and advanced for treating stroke. Mesenchymal stem cells (MSCs) and induced pluripotent stem cells (iPSCs) have received the most attention for treating stroke because of the outstanding paracrine function of MSCs and the three-germ-layer differentiation ability of iPSCs. However, the unsatisfactory homing ability, differentiation, integration, and survival time in vivo limit the effectiveness of MSCs in regenerative medicine. The inherent tumorigenic property of iPSCs ren...
Source: Cell Research - August 19, 2022 Category: Cytology Authors: Han Li Jinghui Wei Xuejia Liu Ping Zhang Juntang Lin Source Type: research
β2-Microglobulin exacerbates neuroinflammation, brain damage, and cognitive impairment after stroke in rats
In this study, we established a rat model of focal cerebral ischemia by occlusion of the middle cerebral artery. We found that β2M levels in the cerebral spinal fluid, serum, and brain tissue were significantly increased in the acute period but gradually decreased during the recovery period. RNA interference was used to inhibit β2M expression in the acute period of cerebral stroke. Tissue staining with 2,3,5-triphenyltetrazolium chloride and evaluation of cognitive function using the Morris water maze test demonstrated that decreased β2M expression in the ischemic penumbra reduced infarct volume and alleviated cognitive...
Source: Cell Research - August 26, 2022 Category: Cytology Authors: Feng Chen Jing Liu Fa-Qiang Li Shuai-Shuai Wang Yan-Yan Zhang Yun-Yun Lu Fang-Fang Hu Rui-Qin Yao Source Type: research
Metformin enhances neural precursor cells migration and functional recovery after ischemic stroke in mice
Exp Brain Res. 2023 Jan 8. doi: 10.1007/s00221-023-06547-3. Online ahead of print.ABSTRACTResident neural precursor cells (NPCs) activation is a promising therapeutic strategy for brain repair. This strategy involves stimulating multiple stages of NPCs development, including proliferation, self-renewal, migration, and differentiation. Metformin, an FDA-approved diabetes drug, has been shown to promote the proliferation and differentiation of NPCs. However, it is still unclear whether metformin promotes the migration of NPCs. EVOS living cell imaging system was used for observing the migration for primary NPCs dynamically i...
Source: Cell Research - January 7, 2023 Category: Cytology Authors: Liang Zhang Jing Zhang Xiaoming Zhu Wei Jiao Yang Yang Youping Wu Likun Yang Yuhai Wang Source Type: research
Synergistic therapeutic effects of intracerebral transplantation of human modified bone marrow-derived stromal cells (SB623) and voluntary exercise with running wheel in a rat model of ischemic stroke
CONCLUSIONS: This study suggests that combination therapy of intracerebral transplantation SB623 cells and voluntary exercise with RW achieves robust neurological recovery and synergistically promotes endogenous neurogenesis and angiogenesis after cerebral ischemia, possibly through a mechanism involving the up-regulation of BDNF and VEGF.PMID:36691091 | DOI:10.1186/s13287-023-03236-4
Source: Cell Research - January 23, 2023 Category: Cytology Authors: Satoru Yabuno Takao Yasuhara Takayuki Nagase Satoshi Kawauchi Chiaki Sugahara Yosuke Okazaki Kakeru Hosomoto Susumu Sasada Tatsuya Sasaki Naoki Tajiri Cesar V Borlongan Isao Date Source Type: research
Cumulative Incidence of Thromboembolism and Prognostic Impact of Stroke in < em > BRAF < /em > V600E-mutant Non-small-cell Lung Cancer
CONCLUSION: A substantial proportion of patients with BRAF V600E-mutant lung cancer experienced thromboembolism during their disease course. CRS of undetermined source may predict a worse prognosis in this population.PMID:36697098 | DOI:10.21873/anticanres.16237
Source: Cell Research - January 25, 2023 Category: Cytology Authors: Sho Yamada Akimasa Sekine Eri Hagiwara Yoko Onodera Erina Tabata Satoshi Ikeda Hideya Kitamura Tomohisa Baba Shigeru Komatsu Takashi Ogura Source Type: research
The role of T cells in acute ischemic stroke
Brain Res Bull. 2023 Mar 9:S0361-9230(23)00055-2. doi: 10.1016/j.brainresbull.2023.03.005. Online ahead of print.ABSTRACTAcute ischemic stroke (AIS) is associated with high rates of disability and mortality, exerting a substantial impact on overall survival and health-related quality of life. Treatment of AIS remains challenging given that the underlying pathologic mechanisms remain unclear. However, recent research has demonstrated that the immune system plays a key role in the development of AIS. Numerous studies have reported infiltration of T cells into ischemic brain tissue. While some types of T cells can promote the...
Source: Cell Research - March 11, 2023 Category: Cytology Authors: Yi-Ran Wang Wen-Qiang Cui Hong-Yun Wu Xiang-Dong Xu Xiang-Qing Xu Source Type: research
Possible Implications of Obesity-Primed Microglia that Could Contribute to Stroke-Associated Damage
Cell Mol Neurobiol. 2023 Mar 20. doi: 10.1007/s10571-023-01329-5. Online ahead of print.ABSTRACTMicroglia, the resident macrophages of the central nervous system, are essential players during physiological and pathological processes. Although they participate in synaptic pruning and maintenance of neuronal circuits, microglia are mainly studied by their activity modulating inflammatory environment and adapting their phenotype and mechanisms to insults detected in the brain parenchyma. Changes in microglial phenotypes are reflected in their morphology, membrane markers, and secreted substances, stimulating neighbor glia and...
Source: Cellular and Molecular Neurobiology - March 20, 2023 Category: Cytology Authors: Ricardo Jair Ram írez-Carreto Yesica Mar ía Rodríguez-Cortés Haydee Torres-Guerrero Anah í Chavarría Source Type: research
Repurposing the K < sub > Ca < /sub > 3.1 Blocker Senicapoc for Ischemic Stroke
Transl Stroke Res. 2023 Apr 24. doi: 10.1007/s12975-023-01152-6. Online ahead of print.ABSTRACTSenicapoc, a small molecule inhibitor of the calcium-activated potassium channel KCa3.1, was safe and well-tolerated in clinical trials for sickle cell anemia. We previously reported proof-of-concept data suggesting that both pharmacological inhibition and genetic deletion of KCa3.1 reduces infarction and improves neurologic recovery in rodents by attenuating neuroinflammation. Here we evaluated the potential of repurposing senicapoc for ischemic stroke. In cultured microglia, senicapoc inhibited KCa3.1 currents with an IC50 of 7...
Source: Cell Research - April 24, 2023 Category: Cytology Authors: Ruth D Lee Yi-Je Chen Hai M Nguyen Latika Singh Connor J Dietrich Benjamin R Pyles Yanjun Cui Jonathan R Weinstein Heike Wulff Source Type: research
Elabela, a Novel Peptide, Exerts Neuroprotective Effects Against Ischemic Stroke Through the APJ/miR-124-3p/CTDSP1/AKT Pathway
In conclusion, these results indicated that ELA could alleviate neuronal apoptosis and axonal damage by upregulating miR-124-3p and activating the CTDSP1/AKT signaling pathway. This study, for the first time, verified the protective effect of ELA against neuronal injury after ischemia and revealed the underlying mechanisms. We demonstrated the potential for the use of ELA as a therapeutic agent in the treatment of ischemic stroke.PMID:37106272 | DOI:10.1007/s10571-023-01352-6
Source: Cellular and Molecular Neurobiology - April 27, 2023 Category: Cytology Authors: Kang-Long Zhang Shuang-Mei Li Jing-Yu Hou Ying-Hui Hong Xu-Xiang Chen Chang-Qing Zhou Hao Wu Guang-Hui Zheng Chao-Tao Zeng Hai-Dong Wu Jia-Ying Fu Tong Wang Source Type: research
The Pathological Mechanism of Neuronal Autophagy-Lysosome Dysfunction After Ischemic Stroke
Cell Mol Neurobiol. 2023 Jun 29. doi: 10.1007/s10571-023-01382-0. Online ahead of print.ABSTRACTThe abnormal initiation of autophagy flux in neurons after ischemic stroke caused dysfunction of autophagy-lysosome, which not only led to autophagy flux blockage, but also resulted in autophagic death of neurons. However, the pathological mechanism of neuronal autophagy-lysosome dysfunction did not form a unified viewpoint until now. In this review, taking the autophagy lysosomal dysfunction of neurons as a starting point, we summarized the molecular mechanisms that led to neuronal autophagy lysosomal dysfunction after ischemic...
Source: Cellular and Molecular Neurobiology - June 29, 2023 Category: Cytology Authors: Guang-Sen Shi Qi-Lin Qin Cheng Huang Zi-Rong Li Zi-Han Wang Yong-Yan Wang Xiu-Ying He Xiao-Ming Zhao Source Type: research
