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Specialty: Laboratory Medicine
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Total 458 results found since Jan 2013.
Predictive mouse model reflects distinct stages of human atheroma in a single carotid artery
Transl Res. 2021 Aug 31:S1931-5244(21)00197-3. doi: 10.1016/j.trsl.2021.08.007. Online ahead of print.ABSTRACTIdentification of patients with high-risk asymptomatic atherosclerotic plaques remains an elusive but essential step in preventing stroke. However, there is a lack of animal model that provides a reproducible method to predict where, when and what types of plaque formation, which fulfils the American Heart Association (AHA) histological classification of human plaques. We have developed a predictive mouse model that reflects different stages of human plaques in a single carotid artery by means of shear-stress modif...
Source: Translational Research : the journal of laboratory and clinical medicine - September 3, 2021 Category: Laboratory Medicine Authors: Joyce Ms Chan Sung-Jin Park Michael Ng Way Cherng Chen Joanne Garnell Kishore Bhakoo Source Type: research
MiR-361-3p alleviates cerebral ischemia –reperfusion injury by targeting NACC1 through the PINK1/Parkin pathway
In conclusion, miR-361-3p could improve ischemia brain injury by targeting NACC1 through the PINK1/Parkin pathway. Therefore, miR-361-3p may serve as a potential therapeutic target for the brain injury after I/R.
Source: Journal of Molecular Histology - January 24, 2022 Category: Laboratory Medicine Source Type: research
Elabela-APJ axis mediates angiogenesis via YAP/TAZ pathway in cerebral ischemia/reperfusion injury
Transl Res. 2023 Feb 20:S1931-5244(23)00020-8. doi: 10.1016/j.trsl.2023.02.002. Online ahead of print.ABSTRACTAngiogenesis helps to improve neurological recovery by repairing damaged brain tissue and restoring cerebral blood flow (CBF). The role of the Elabela (ELA)-Apelin receptor (APJ) system in angiogenesis has gained much attention. We aimed to investigate the function of endothelial ELA on post-ischemic cerebral angiogenesis. Here, we demonstrated that the endothelial ELA expression was upregulated in the ischemic brain and treatment with ELA-32 mitigated brain injury and enhanced the restoration of CBF and newly form...
Source: Translational Research : the journal of laboratory and clinical medicine - February 22, 2023 Category: Laboratory Medicine Authors: Wenyu Li Pengfei Xu Lingqi Kong Shuo Feng Nan Shen Hongmei Huang Wuxuan Wang Xiang Xu Xinyue Wang Guoping Wang Yan Zhang Wen Sun Wei Hu Xinfeng Liu Source Type: research
LncRNA < em > PCBP1-AS1 < /em > Induces Cerebral Ischemia/Reperfusion Injury via the < em > miR-506-3p/CCL2 < /em > Axis
CONCLUSION: LncRNA PCBP1-AS1 sequesters miR-506-3p to upregulate CCL2 expression, thereby aggravating I/R injury, suggesting its potential for RNA-targeted treatment of cerebral ischemic stroke.PMID:37437927
Source: Annals of Clinical and Laboratory Science - July 12, 2023 Category: Laboratory Medicine Authors: Zhili He Ling Chen Wei Zhang Source Type: research
