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Diagnostic and Prognostic Blood Biomarkers in Transient Ischemic Attack and Minor Ischemic Stroke: An Up-To-Date Narrative Review
Transient ischemic attack (TIA) is a brief episode of focal neurological deficit, lasting less than 24 hours, and reaching its climax usually within minutes. Patients with an even tiny ischemic brain lesion on imaging are considered, on tissue-based criteria, to have a minor ischemic stroke (MIS), usually with mild and non-disabling symptoms.1 Although a consensus clinical definition for MIS is currently lacking, 5 working definitions based on information from head computed tomography (CT) scan and clinical examination have been developed by the National Institute of Neurological Disorder and Stroke (NINDS) rt-PA stroke study Investigators.
Source: Journal of Stroke and Cerebrovascular Diseases - January 10, 2022 Category: Neurology Authors: Matteo Foschi, Marina Padroni, Samir Abu-Rumeileh, Ahmed Abdelhak, Michele Russo, Lucio D'Anna, Maria Guarino Tags: Review Article Source Type: research

Time to ct scan imaging after symptom onset among ischeamic stroke patients presenting to a quaternary hospital in ghana
This study sought to determine the time of onset of symptoms to the time a CT imaging was done among patients presenting with acute stroke at the Korle-Bu Teaching Hospital.
Source: Journal of Stroke and Cerebrovascular Diseases - March 30, 2023 Category: Neurology Authors: F. Duodu, D. Brodie Mends, B. Agbinko-Djobalar, P. Pekyi-Boateng, M. Amerwornu, P Adjei, A Akpalu, K Nkromah Source Type: research

Thrombectomy in ischemic stroke patients with alberta stroke program early computed tomography score 4-5 and 0-3: Factors associated with favorable outcome
Recently published results of the ANGEL-ASPECT and SELECT2 trials suggest that stroke patients presenting with low Alberta Stroke Program Early Computed Tomography Score (ASPECTS) benefit from mechanical thrombectomy. Purpose of this retrospective study was to identify factors that are associated with a favorable outcome in patients with low ASPECTS of 4-5 and 0-3 undergoing mechanical thrombectomy.
Source: Journal of Stroke and Cerebrovascular Diseases - May 6, 2023 Category: Neurology Authors: Ludger Feyen, Helge Kniep, Christian Blockhaus, Martin Weinzierl, Marcus Katoh, Patrick Haage, Stefan Rohde, Nico M ünnich Source Type: research

DWI-ASPECTS as a Predictor of Dramatic Recovery After Intravenous Recombinant Tissue Plasminogen Activator Administration in Patients With Middle Cerebral Artery Occlusion Brief Reports
Conclusions— DWI-ASPECTS predicted short-term recovery in patients with middle cerebral artery trunk occlusion receiving intravenous recombinant tissue plasminogen activator. In patients with lower DWI-ASPECTS, there may still be benefit from early recanalization.
Source: Stroke - January 18, 2013 Category: Neurology Authors: Aoki, J., Kimura, K., Shibazaki, K., Sakamoto, Y. Tags: Cerebrovascular disease/stroke, Fibrinolysis, CT and MRI Brief Reports Source Type: research

Timeliness of Intravenous Thrombolysis via Telestroke in Georgia Brief Reports
Conclusions— The greatest opportunity to expedite acute thrombolysis via telestroke is by shortening the time from ED arrival to telestroke patient registration.
Source: Stroke - August 26, 2013 Category: Neurology Authors: Bruno, A., Lanning, K. M., Gross, H., Hess, D. C., Nichols, F. T., Switzer, J. A. Tags: Thrombolysis, Other Stroke Treatment - Medical Brief Reports Source Type: research

REVASCAT: a randomized trial of revascularization with SOLITAIRE FR® device vs. best medical therapy in the treatment of acute stroke due to anterior circulation large vessel occlusion presenting within eight‐hours of symptom onset
REVASCAT is a prospective, multicenter, randomized trial seeking to establish whether subjects meeting following main inclusion criteria: age 18‐80, baseline National Institutes of Health Stroke Scale ≥6, evidence of intracranial internal carotid artery or proximal (M1 segment) middle cerebral artery occlusion, Alberta Stroke Program Early Computed Tomography score of >7 on non‐contrast CT or >6 on diffusion‐weighted magnetic resonance imaging , ineligible for or with persistent occlusion after intravenous alteplase and procedure start within 8 hours from symptom onset, have higher rates of favorable outcome ...
Source: International Journal of Stroke - November 10, 2013 Category: Neurology Authors: Carlos A. Molina, Angel Chamorro, Àlex Rovira, Angeles Miquel, Joaquin Serena, Luis San Roman, Tudor G. Jovin, Antoni Davalos, Erik Cobo Tags: Protocols Source Type: research

Early and Continuous Neurologic Improvements after Intravenous Thrombolysis Are Strong Predictors of Favorable Long-term Outcomes in Acute Ischemic Stroke
Background: Intravenously administered tissue plasminogen activator (IV tPA) remains the only approved therapeutic agent for arterial recanalization in acute ischemic stroke (AIS). Considerable proportion of AIS patients demonstrate changes in their neurologic status within the first 24 hours of intravenous thrombolysis with IV tPA. However, there are little available data on the course of clinical recovery in subacute 2- to 24-hour window and its impact. We evaluated whether neurologic improvement at 2 and 24 hours after IV tPA bolus can predict functional outcomes in AIS patients at 3 months.Methods: Data for consecutive...
Source: Journal of Stroke and Cerebrovascular Diseases - August 19, 2013 Category: Neurology Authors: Leonard LL. Yeo, Prakash Paliwal, Hock L. Teoh, Raymond C. Seet, Bernard PL. Chan, Benjamin Wakerley, Shen Liang, Rahul Rathakrishnan, Vincent F. Chong, Eric YS. Ting, Vijay K. Sharma Tags: Original Articles Source Type: research

The Essential Can Be Invisible to the Eyes: The “Fogging Effect” Phenomenon in the Subacute Stage of Ischemic Stroke
We report a patient who presented with a vanishing stroke on a follow-up brain computed tomography scan, a condition known as the “fogging effect” phenomenon.
Source: Journal of Stroke and Cerebrovascular Diseases - September 20, 2012 Category: Neurology Authors: Irapuá Ferreira Ricarte, José Luiz Pedroso, Flávio Augusto Carvalho, Agessandro Abrahão, Raul Alberto Valiente, Maramélia Miranda Alves, Daniela Laranja Gomes, Gisele Sampaio Silva Tags: Case Reports Source Type: research

Comparison of CT and DWI Findings in Ischemic Stroke Patients within 3 Hours of Onset
This study compared the detection rate of ischemic lesions within 3 hours of onset by computed tomography (CT) and diffusion-weighted magnetic resonance imaging (DWI). The study group comprised 130 patients (71 men; median age, 75 years) with an anterior territory stroke who underwent CT and DWI within 3 hours of onset. The lesions revealed on CT and DWI were assessed using the CT–Alberta Stroke Program Early CT Score (ASPECTS) and DWI-ASPECTS, and detection rates were compared for each ASPECTS region. The detection rate of ischemic lesions was higher on DWI than on CT (76.9% v 30.0%; P 
Source: Journal of Stroke and Cerebrovascular Diseases - October 8, 2012 Category: Neurology Authors: Mutsumi Mitomi, Kazumi Kimura, Junya Aoki, Yasuyuki Iguchi Tags: Original Articles Source Type: research

Clinical Use of Computed Tomographic Perfusion for the Diagnosis and Prediction of Lesion Growth in Acute Ischemic Stroke
Conclusions: In real-world use, acute imaging with CTP did not predict stroke or DWI lesions with sufficient accuracy. Our findings argue against the use of CTP for screening AIS patients until real-world implementations match the accuracy reported from specialized research centers.
Source: Journal of Stroke and Cerebrovascular Diseases - December 17, 2012 Category: Neurology Authors: Branko N. Huisa, William P. Neil, Ronald Schrader, Marcel Maya, Benedict Pereira, Nhu T. Bruce, Patrick D. Lyden Tags: Original Articles Source Type: research

Addition of Hyperacute MRI Aids in Patient Selection, Decreasing the Use of Endovascular Stroke Therapy Clinical Sciences
Conclusions— Implementation of hyperacute MRI protocol decreases the number of endovascular stroke interventions by half. Further investigation of MRI use for patient selection is warranted.
Source: Stroke - January 27, 2014 Category: Neurology Authors: Wisco, D., Uchino, K., Saqqur, M., Gebel, J. M., Aoki, J., Alam, S., George, P., Newey, C. R., Man, S., Tateishi, Y., McNeil, J., Winfield, M., Cheng-Ching, E., Hui, F. K., Toth, G., Bain, M., Rasmussen, P. A., Masaryk, T., Ruggieri, P., Hussain, M. S. Tags: Acute Cerebral Infarction, Computerized tomography and Magnetic Resonance Imaging Clinical Sciences Source Type: research

Vertebral Artery Hypoplasia: Frequency and Effect on Cerebellar Blood Flow Characteristics Clinical Sciences
Conclusions— VAH is a frequent vascular variant that can lead to a relative regional hypoperfusion in the PICA territory. Additional research should clarify the pathophysiological role of VAH in PCI.
Source: Stroke - April 28, 2014 Category: Neurology Authors: Thierfelder, K. M., Baumann, A. B., Sommer, W. H., Armbruster, M., Opherk, C., Janssen, H., Reiser, M. F., Straube, A., von Baumgarten, L. Tags: Brain Circulation and Metabolism, Computerized tomography and Magnetic Resonance Imaging, Pathology of Stroke, Risk Factors for Stroke Clinical Sciences Source Type: research

Relationship Between Magnetic Resonance Angiography–Diffusion-weighted Imaging Mismatch and Clinical Outcome in Endovascular Treatment for Acute Ischemic Stroke: Subgroup Analysis of the Recovery by Endovascular Salvage for Cerebral Ultra-acute Embolism–Japan Registry
Background: The presence or absence of the penumbra area is important when performing reperfusion therapy in patients with acute ischemic stroke. As a predictor of this penumbra area, magnetic resonance angiography (MRA)–diffusion-weighted imaging (DWI) mismatch is attracting attention. The usefulness of MRA–DWI mismatch (MDM) using the DWI–Alberta Stroke Program Early Computed Tomography Score (ASPECTS) in endovascular treatment (EVT) of patients with cerebral large vessel occlusion was evaluated.Methods: Of 1442 patients registered in the Recovery by Endovascular Salvage for Cerebral Ultra-acute Embolism–Japan Re...
Source: Journal of Stroke and Cerebrovascular Diseases - March 31, 2014 Category: Neurology Authors: Ichiro Deguchi, Tomohisa Dembo, Shinichi Yoshimura, Nobuyuki Sakai, Yasushi Okada, Kazuo Kitagawa, Kazumi Kimura, Toshio Hyogo, Hiroshi Yamagami, Yusuke Egashira, Norio Tanahashi Tags: Original Articles Source Type: research

Prediction of recanalization in acute stroke patients receiving intravenous and endovascular revascularization therapy
ConclusionThe overall likelihood of recanalization was the highest in the endovascular group, and higher for intravenous thrombolysis compared with no revascularization therapy. However, our statistical models of recanalization for each individual patient indicate significant variability between treatment options, suggesting the need to include this prediction in the personalized treatment selection.
Source: International Journal of Stroke - June 30, 2014 Category: Neurology Authors: Guangming Zhu, Patrik Michel, Tudor Jovin, James T. Patrie, Wenjun Xin, Ashraf Eskandari, Weiwei Zhang, Max Wintermark Tags: Research Source Type: research

Persistent Cognitive Impairment After Transient Ischemic Attack Clinical Sciences
Conclusions— More than a third of patients with TIA have impairment of ≥1 cognitive domain within 3 months after their TIA. The affected domains fit in the vascular cognitive impairment profile.
Source: Stroke - July 28, 2014 Category: Neurology Authors: van Rooij, F. G., Schaapsmeerders, P., Maaijwee, N. A. M., van Duijnhoven, D. A. H. J., de Leeuw, F.-E., Kessels, R. P. C., van Dijk, E. J. Tags: Behavioral/psychosocial - stroke, Behavioral Changes and Stroke, Transient Ischemic Attacks Clinical Sciences Source Type: research