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Multimodal Magnetic Resonance Imaging and Therapeutic Intervention With Yi-nao-jie-yu Decoction in a Rat Model of Post-stroke Depression
Post-stroke depression (PSD) is the most common neuropsychiatric complication after a stroke, though its neuropathological characteristics have not been fully elucidated. Comprehensive and non-invasive magnetic resonance (MR) assessment techniques are urgently needed for current research, as diffusion tensor imaging (DTI), arterial spin labeling (ASL), and magnetic resonance spectroscopy (MRS) can allow for a comprehensive assessment of neuropathological changes in the brain. These techniques can provide information about microscopic tissue integrity, cerebral perfusion, and cerebral metabolism, and can serve as powerful t...
Source: Frontiers in Psychiatry - November 4, 2020 Category: Psychiatry Source Type: research

Panaxatriol saponins promotes angiogenesis and enhances cerebral perfusion after ischemic stroke in rats
Panaxatriol saponins (PTS), an extract from the traditional Chinese herb Panax notoginseng, which has been used to treat ischemic stroke for many years in China. However, the mechanism underlying the effects o...
Source: BMC Complementary and Alternative Medicine - January 23, 2017 Category: Complementary Medicine Authors: Zhen Hui, Du-Juan Sha, Su-Lei Wang, Chao-Sheng Li, Jian Qian, Jing-Qing Wang, Yang Zhao, Jing-Hua Zhang, Hong-Yu Cheng, Hui Yang, Lin-Jie Yu and Yun Xu Source Type: research

Effect of Neurorepair for Motor Functional Recovery Enhanced by Total Saponins From Trillium tschonoskii Maxim. Treatment in a Rat Model of Focal Ischemia
Trillium tschonoskii Maxim. (TTM), is a perennial herb from Liliaceae, that has been widely used as a traditional Chinese medicine treating cephalgia and traumatic hemorrhage. The present work was designed to investigate whether the total saponins from Trillium tschonoskii Maxim. (TSTT) would promote brain remodeling and improve gait impairment in the chronic phase of ischemic stroke. A focal ischemic model of male Sprague-Dawley (SD) rats was established by permanent middle cerebral artery occlusion (MCAO). Six hours later, rats were intragastrically treated with TSTT (120, 60, and 30 mg/kg) and once daily up to day 30. ...
Source: Frontiers in Pharmacology - December 10, 2021 Category: Drugs & Pharmacology Source Type: research