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Clinical Efficacy and Short-Term Prognosis of Butylphthalide and Sodium Chloride Injection Compared to Edaravone in the Treatment of Patients with Acute Stroke
CONCLUSIONS: This study highlights the positive impact of butylphthalide and edaravone on the therapeutic effect and short-term prognosis in acute stroke patients. The findings provide valuable guidance for future research and enhance our understanding of these drugs' mechanisms, offering the potential for improved stroke management and patient outcomes.PMID:37499159
Source: Alternative Therapies in Health and Medicine - July 27, 2023 Category: Complementary Medicine Authors: Dan Yang Mi Zhang Xiaoyan Wang Jianna Zhang Source Type: research

Electroacupuncture Regulates Endoplasmic Reticulum Stress and Ameliorates Neuronal Injury in Rats with Acute Ischemic Stroke
This study aimed to determine whether endoplasmic reticulum stress (ERS) could contribute to the protective effects of EA in cerebral ischemia/reperfusion injury (CIRI) to provide a rationale for the widespread clinical use of EA. Rats were divided into the sham-operated (sham) group, the CIRI (model) group, and the EA group. Rats in the model group were subjected to middle cerebral artery occlusion (MCAO) for 2 h followed by 72 h of reperfusion. Rats with CIRI were treated daily with EA at GV20 and ST36 for a total of 3 days. The Longa scoring system and adhesive removal somatosensory test were applied to evaluate neurolo...
Source: Evidence-based Complementary and Alternative Medicine - August 26, 2021 Category: Complementary Medicine Authors: Ya-Min Zhang Hong Xu Su-Hui Chen Hua Sun Source Type: research

Systematic Understanding of Mechanism of Danggui Shaoyao San against Ischemic Stroke Using a Network Pharmacology Approach
CONCLUSIONS: This study showed that DSS can treat IS through multiple targets and routes and provided new insights to explore the mechanisms of DSS against IS.PMID:35035503 | PMC:PMC8754614 | DOI:10.1155/2022/3747285
Source: Evidence-based Complementary and Alternative Medicine - January 17, 2022 Category: Complementary Medicine Authors: Sijie Li Yong Yang Wei Zhang Haiyan Li Wantong Yu Chen Gao Jiali Xu Wenbo Zhao Changhong Ren Source Type: research

Effect of Electroacupuncture on Neurological Deficit and Activity of Clock and Bmal1 in Cerebral Ischemic Rats
This study aims to explore the effect of acupuncture at acupoints GV20 and BL23 on neuroprotection and anti-apoptosis in middle cerebral artery occlusion (MCAO) rats and expression of apoptosis and circadian rhythm related proteins. Male Sprague-Dawley (SD) rats were randomly divided into five groups: normal group (Normal), sham model group (Sham MCAO), MCAO model group (MCAO), sham electroacupuncture group (Sham EA) and electroacupuncture group (EA). The MCAO model was prepared by electrocoagulation. The first acupuncture treatment was performed within 2 h after surgery, and then acupuncture therapy was performed on 1st d...
Source: Journal of Huazhong University of Science and Technology -- Medical Sciences -- - December 1, 2020 Category: Research Source Type: research

Neuroprotective Effect of Moxibustion on Cerebral Ischemia/Reperfusion Injury in Rats by Downregulating NR2B Expression
CONCLUSIONS: Moxibustion can improve neurological dysfunction and decrease infarction area and neuronal apoptosis caused by cerebral ischemia/reperfusion in rats. Its neuroprotective mechanism may be related to downregulating the expression of NR2B.PMID:34733340 | PMC:PMC8560262 | DOI:10.1155/2021/5370214
Source: Evidence-based Complementary and Alternative Medicine - November 4, 2021 Category: Complementary Medicine Authors: Zhong Di Qin Guo Quanai Zhang Source Type: research

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