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Intrathecal Injection of Allogenic Bone Marrow-Derived Mesenchymal Stromal Cells in Treatment of Patients with Severe Ischemic Stroke: Study Protocol for a Randomized Controlled Observer-Blinded Trial
AbstractMesenchymal stromal cells (MSCs) can differentiate into multiple tissues. Preclinical studies have shown that MSC-based therapy is a potential new treatment approach for ischemic stroke. These results support the urgent need for further studies of MSC transplantation in the treatment of ischemic stroke in humans. Here, we develop a prospective, randomized, controlled, observer-blinded phase II trial to assess the clinical safety, feasibility, and therapeutic mechanisms of allogenic bone marrow-derived MSCs (BM-MSCs) by intrathecal infusion in the treatment of patients with cerebral infarction within the middle cere...
Source: Translational Stroke Research - May 23, 2018 Category: Neurology Source Type: research

Identification of novel risk loci for restless legs syndrome in genome-wide association studies in individuals of European ancestry: a meta-analysis
Publication date: November 2017 Source:The Lancet Neurology, Volume 16, Issue 11 Author(s): Barbara Schormair, Chen Zhao, Steven Bell, Erik Tilch, Aaro V Salminen, Benno Pütz, Yves Dauvilliers, Ambra Stefani, Birgit Högl, Werner Poewe, David Kemlink, Karel Sonka, Cornelius G Bachmann, Walter Paulus, Claudia Trenkwalder, Wolfgang H Oertel, Magdolna Hornyak, Maris Teder-Laving, Andres Metspalu, Georgios M Hadjigeorgiou, Olli Polo, Ingo Fietze, Owen A Ross, Zbigniew Wszolek, Adam S Butterworth, Nicole Soranzo, Willem H Ouwehand, David J Roberts, John Danesh, Richard P Allen, Christopher J Earley, William G Ondo, Lan Xiong,...
Source: The Lancet Neurology - October 11, 2017 Category: Neurology Source Type: research

Intra‐arterial bone marrow mononuclear cells (BM‐MNCs) transplantation in acute ischemic stroke (IBIS trial): protocol of a phase II, randomized, dose‐finding, controlled multicenter trial
DiscussionThis is the first trial to explore efficacy of different doses of intra‐arterial bone marrow mononuclear cell in moderate‐to‐severe acute ischemic stroke patients. The trial is registered as NCT02178657.
Source: International Journal of Stroke - June 4, 2015 Category: Neurology Authors: Francisco Moniche, Irene Escudero, Elena Zapata‐Arriaza, María Usero‐Ruiz, María Prieto‐León, Javier Torre, Miguel‐Angel Gamero, Jose Antonio Tamayo, Juan‐José Ochoa‐Sepúlveda, José Maestre, Magdalena Carmona, Pilar Piñero, Cristina Cal Tags: Protocol Source Type: research