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Total 727 results found since Jan 2013.
Diethylcarbamazine elicits Ca < sup > 2+ < /sup > signals through TRP-2 channels that are potentiated by emodepside in < em > Brugia malayi < /em > muscles
Antimicrob Agents Chemother. 2023 Sep 20:e0041923. doi: 10.1128/aac.00419-23. Online ahead of print.ABSTRACTFilarial nematode infections are a major health concern in several countries. Lymphatic filariasis is caused by Wuchereria bancrofti and Brugia spp. affecting over 120 million people. Heavy infections can lead to elephantiasis, which has serious effects on individuals' lives. Although current anthelmintics are effective at killing microfilariae in the bloodstream, they have little to no effect against adult parasites found in the lymphatic system. The anthelmintic diethylcarbamazine is one of the central pillars of l...
Source: Antimicrobial Agents and Chemotherapy - September 20, 2023 Category: Microbiology Authors: Paul D E Williams Sudhanva S Kashyap Alan P Robertson Richard J Martin Source Type: research
< em > Plasmodium falciparum < /em > GCN5 plays a key role in regulating artemisinin resistance-related stress responses
Antimicrob Agents Chemother. 2023 Sep 13:e0057723. doi: 10.1128/aac.00577-23. Online ahead of print.ABSTRACTPlasmodium falciparum causes the most severe malaria and is exposed to various environmental and physiological stresses in the human host. Given that GCN5 plays a critical role in regulating stress responses in model organisms, we aimed to elucidate PfGCN5's function in stress responses in P. falciparum. The protein level of PfGCN5 was substantially induced under three stress conditions [heat shock, low glucose starvation, and dihydroartemisinin, the active metabolite of artemisinin (ART)]. With a TetR-DOZI condition...
Source: Antimicrobial Agents and Chemotherapy - September 13, 2023 Category: Microbiology Authors: Amuza Byaruhanga Lucky Chengqi Wang Ahmad Rushdi Shakri Mohammad Kalamuddin Anongruk Chim-Ong Xiaolian Li Jun Miao Source Type: research
Combination of inhibitors for two glycolytic enzymes portrays high synergistic efficacy against < em > Cryptosporidium parvum < /em >
Antimicrob Agents Chemother. 2023 Sep 1:e0056923. doi: 10.1128/aac.00569-23. Online ahead of print.ABSTRACTCryptosporidium is an intracellular protozoan parasite that causes serious enteric disease in humans and in a wide range of animals worldwide. Despite its high prevalence, no effective therapeutic drugs are available against life-threatening cryptosporidiosis in at-risk populations including malnourished children, immunocompromised patients, and neonatal calves. Thus, new efficacious drugs are urgently needed to treat all susceptible populations with cryptosporidiosis. Unlike other apicomplexans, Cryptosporidium parvu...
Source: Antimicrobial Agents and Chemotherapy - September 1, 2023 Category: Microbiology Authors: Shahbaz M Khan Muhammad Rashid Bajwa Rachael Y Lahar William H Witola Source Type: research
PLGA Nanoparticles as New Drug Delivery Systems in Leishmaniasis Chemotherapy: A Review of Current Practices
Curr Med Chem. 2023 Aug 23. doi: 10.2174/0929867331666230823094737. Online ahead of print.ABSTRACTAlthough leishmaniasis is one of the most common parasitic diseases, its traditional treatments suffer from some serious problems. To solve such issues, we can take advantage of the effective nanoparticle-based approaches to deliver anti-leishmanial agents into leishmania-infected macrophages either using passive targeting or using macrophage-related receptors. Despite the high potential of nanotechnology, Liposomal Amphotericin B (AmBisome®) is the only FDA-approved nanoparticle-based anti-leishmanial therapy. In an effort t...
Source: Current Medicinal Chemistry - August 24, 2023 Category: Chemistry Authors: Alaleh Valiallahi Zahra Vazifeh Zahra Rezanejad Gatabi Maryam Davoudi Iman Rezanezhad Gatabi Source Type: research
Organogold(III)-dithiocarbamate compounds and their coordination analogues as anti-tumor and anti-leishmanial metallodrugs
J Inorg Biochem. 2023 Jul 29;247:112346. doi: 10.1016/j.jinorgbio.2023.112346. Online ahead of print.ABSTRACTThe limited chemical stability of gold(III)-based compounds in physiological environment has been a challenge in drug discovery, and organometallic chemistry might provide the solution to overcome this issue. In this work, four novel cationic organogold(III)-dithiocarbamate complexes of general structure [(C^N)AuIIIDTC]PF6 (C1a - C4a, DTC = dithiocarbamate, L1 - L4, C^N = 2-anilinopyridine) are presented, and compared to their coordination gold(III)-dithiocarbamate analogues [AuIIIDTCCl2] (C1b - C4b), as potential a...
Source: Journal of Inorganic Biochemistry - August 3, 2023 Category: Biochemistry Authors: Ana Luiza de Andrade Querino Alessandra Mara de Sousa Sophie R Thomas Geraldo Magela de Lima Dalton Dittz Angela Casini Rubens Lima do Monte-Neto Heveline Silva Source Type: research
