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Total 257 results found since Jan 2013.
Convergent activation of two-pore channels mediated by the NAADP-binding proteins JPT2 and LSM12
Sci Signal. 2023 Aug 22;16(799):eadg0485. doi: 10.1126/scisignal.adg0485. Epub 2023 Aug 22.ABSTRACTThe second messenger nicotinic acid adenine dinucleotide phosphate (NAADP) evokes calcium ion (Ca2+) release from endosomes and lysosomes by activating two-pore channels (TPCs) on these organelles. Rather than directly binding to TPCs, NAADP associates with proteins that indirectly confer NAADP sensitivity to the TPC complex. We investigated whether and how the NAADP-binding proteins Jupiter microtubule-associated homolog 2 (JPT2) and like-Sm protein 12 (LSM12) contributed to NAADP-TPC-Ca2+ signaling in human cells. Biochemic...
Source: Science Signaling - August 22, 2023 Category: Biomedical Science Authors: Gihan S Gunaratne Eugen Brailoiu Sushil Kumar Yu Yuan James T Slama Timothy F Walseth Sandip Patel Jonathan S Marchant Source Type: research
Comprehensive analysis of transcriptome-wide N6-methyladenosine methylomes in the Barrett's esophagus in rats
CONCLUSION: Our study is the first to perform comprehensive and transcriptome-wide maps to identify the potential roles played by m6A methylation in BE, which widely involved in oxidative stress. This foresees a guiding role in revealing the molecular mechanism of m6A-mediated genes that govern the pathogenesis and progression of BE and EAC.PMID:37454940 | DOI:10.1016/j.ygeno.2023.110687
Source: Genomics - July 16, 2023 Category: Genetics & Stem Cells Authors: Ke Zou Hui Dong Mengmeng Li Ying Zhang Kai Zhang Danlin Song Chuanlian Chu Source Type: research
A Review on Vitamin D Deficiency and Related Disorders: What is the Right Serum Vitamin D Level?
J Assoc Physicians India. 2023 May;71(5):11-12. doi: 10.5005/japi-11001-0240.ABSTRACTTo maintain a healthy skeleton, vitamin D is crucial for phosphate as well as calcium uptake. It is of great significance for maintaining the various adaptive and innate immune response components. To reduce the development of various immune-related disorders, such as diabetes, hypertension, cardiovascular diseases, rheumatoid arthritis, and coronavirus disease 2019 (COVID-19), numerous studies evaluating the optimal threshold levels for serum 25-hydroxyvitamin D [25(OH)D]. It is documented in various evidence to increase the serum 25(OH)D...
Source: Cancer Control - June 25, 2023 Category: Cancer & Oncology Authors: Ganapathi Bantwal Source Type: research
Blood pressure control following angiotensin antagonists substitution: insights from a triple-blind, randomized, clinical trial
This article is protected by copyright. All rights reserved.PMID:37341147 | DOI:10.1002/jcph.2294
Source: The Journal of Clinical Pharmacology - June 21, 2023 Category: Drugs & Pharmacology Authors: Amin Sharifan Maryam Bahreini Haleh Ashraf Farhad Najmeddin Source Type: research
