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Infectious Disease: MERS
Vaccination: Veterinary Vaccinations
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Total 240 results found since Jan 2013.
Hyperimmune immunoglobulin for people with COVID-19
CONCLUSIONS: We included data from five RCTs that evaluated hIVIG compared to standard therapy, with participants with moderate-to-severe disease. As the studies evaluated different preparations (from humans or from various animals) and doses, we could not pool them. hIVIG prepared from humans may have little to no impact on mortality, and clinical improvement and worsening. hIVIG may increase grade 3-4 adverse events. Studies did not evaluate quality of life. RBD-specific polyclonal F(ab´)2 fragments of equine antibodies may reduce mortality and serious adverse events, and may reduce clinical worsening. However, the stud...
Source: Cochrane Database of Systematic Reviews - January 26, 2023 Category: General Medicine Authors: Catherine Kimber Sarah J Valk Khai Li Chai Vanessa Piechotta Claire Iannizzi Ina Monsef Erica M Wood Abigail A Lamikanra David J Roberts Zoe McQuilten Cynthia So-Osman Lise J Estcourt Nicole Skoetz Source Type: research
Gain-of-function research
Adv Appl Microbiol. 2022;120:79-111. doi: 10.1016/bs.aambs.2022.06.002. Epub 2022 Jul 13.ABSTRACTThe term Gain-of-Function (GoF) describes the gain of new functions by organisms through genetic changes, which can naturally occur or by experimental genetic modifications. Gain-of-Function research on viruses is enhancing transmissibility, virus replication, virulence, host range, immune evasion or drug and vaccine resistance to get insights into the viral mechanisms, to create and analyze animal models, to accelerate drug and vaccine development and to improve pandemic preparedness. A subset is the GoF research of concern (G...
Source: Advances in Applied Microbiology - October 15, 2022 Category: Microbiology Authors: K P Saalbach Source Type: research
