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The Use of < em > In Silico < /em > Methods to Identify and Assess Antigenic Regions Suitable for the Development of Peptide-based Pan-viral Vaccines
We report a pan-antigenic peptide region with strong affinity for MHC-I and MHC-II, and good immunogenic potential. According to the output from the relevant in silico tools, the peptide was predicted to be non-toxic, non-allergic and to possess the desired physicochemical properties for potentially successful vaccine production. With further investigation and optimisation, this peptide could be considered for use in the development of a broad-spectrum anti-viral vaccine that may protect against emerging new viruses. Our approach of using in silico methods to identify candidate antigenic peptides with the desired physicoch...
Source: Alternatives to Laboratory Animals : ATLA - August 7, 2023 Category: Research Authors: Shayana Saravanakumar Jhinuk Chatterjee Source Type: research

Promoting immunity with novel targeting antigen delivery vehicle based on bispecific nanobody
In conclusion, our results demonstrate the potential of bispecific nanobody as a novel and efficient DC-specific antigen delivery vehicle. This highlights the potential to expand targeted delivery to the field of animal epidemic diseases and provides a reference for the general application of nanotechnology in viral diseases.PMID:37116343 | DOI:10.1016/j.intimp.2023.110140
Source: International Immunopharmacology - April 28, 2023 Category: Allergy & Immunology Authors: Haiwei Cheng Li Yang Liting Hou Zizheng Cai Xiaoming Yu Luping Du Jin Chen Qisheng Zheng Source Type: research

Addressing the Threat of Emerging Viral Infections
Keio J Med. 2023;72(1):27. doi: 10.2302/kjm.ABSTRACT_72_1-2.ABSTRACTEmerging infections are caused when microorganisms that are maintained in a reservoir where they cause no harm, transmit from the reservoir to a new host. I have been studying the replication, molecular basis for pathogenesis, and host responses to emerging viruses, including influenza virus, Ebola virus, and SARS-CoV-2, and using the knowledge gained from these studies to develop antivirals and vaccines.Influenza viruses cause epidemics every winter, but occasionally new influenza viruses emerge and spread worldwide (pandemic). We established a technique ...
Source: The Keio Journal of Medicine - March 26, 2023 Category: Universities & Medical Training Authors: Yoshihiro Kawaoka Source Type: research

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