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Infectious Disease: Endemics
Vaccination: AIDS Vaccine
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Total 32 results found since Jan 2013.
GMP manufacture of Shigella flexneri 2a Artificial Invaplex (Invaplex < sub > AR < /sub > ) and evaluation in a Phase 1 Open-label, dose escalating study administered intranasally to healthy, adult volunteers
Vaccine. 2023 Sep 2:S0264-410X(23)00995-7. doi: 10.1016/j.vaccine.2023.08.051. Online ahead of print.ABSTRACTShigella species cause severe disease among travelers to, and children living in, endemic countries. Although significant efforts have been made to improve sanitation, increased antibiotic resistance and other factors suggest an effective vaccine is a critical need. Artificial Invaplex (InvaplexAR) is a subunit vaccine approach complexing Shigella LPS with invasion plasmid antigens. In pre-clinical studies, the InvaplexAR vaccine demonstrated increased immunogenicity as compared to the first generation product and w...
Source: Vaccine - September 4, 2023 Category: Allergy & Immunology Authors: Christopher Duplessis Kristen A Clarkson K Ross Turbyfill Ashley N Alcala Ramiro Gutierrez Mark S Riddle Tida Lee Kristopher Paolino Hailey P Weerts Amanda Lynen Edwin V Oaks Chad K Porter Robert Kaminski Source Type: research
Viral hepatitis in persons living with HIV in the post-COVID era
AIDS Rev. 2023;25(1):1-13. doi: 10.24875/AIDSRev.M23000061.ABSTRACTCoinfection with hepatitis viruses A to E is frequent in persons living with HIV (PLWH) and causes significant morbidity and mortality. Oro-fecal transmissible hepatitis A and E mostly produce acute self-limited episodes in poor income regions and in non-vaccinated travelers. In high-income countries, outbreaks of hepatitis A occur in men having sex with men (MSM) and chronic hepatitis E is occasionally reported among PLWH with severe immunodeficiency. Chronic hepatitis B, C, and D are frequent in PLWH in highly endemic regions and globally in persons who i...
Source: AIDS Reviews - March 23, 2023 Category: Infectious Diseases Authors: Vicente Soriano V íctor Moreno-Torres Carmen de Mendoza Octavio Corral Pablo Barreiro Source Type: research
