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Identification of hub genes associated with outcome of clear cell renal cell carcinoma.
Authors: Li R, Wang L, Wang X, Geng RX, Li N, Liu XH Abstract Clear cell renal cell carcinoma (ccRCC) is one of the most common tumor types of the urinary system. Bioinformatics tools have been used to identify new biomarkers of ccRCC and to explore the mechanisms underlying development and progression of ccRCC. The present study analyzed the differentially expressed genes (DEGs) associated with RCC using data obtained from Gene Expression Omnibus datasets and GEO2R software. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis of these DEGs was performed and analyzed us...
Source: Oncology Letters - March 29, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Downregulation of peroxiredoxin II suppresses the proliferation and metastasis of gastric cancer cells.
Authors: Niu L, Liu A, Xu W, Yang L, Zhu W, Gu Y Abstract Peroxiredoxin (Prx) II is an imperative member of the superfamily of peroxidases. It serves an essential role in scavenging organic hydroperoxide and H2O2. It is involved in the development of various malignant tumors. In order to investigate the significance of Prx II expressions level in gastric cancer (GC), downregulation of Prx II was performed to investigate its role in the proliferation and migration of gastric adenocarcinoma cells. In GC cells and 45 GC specimens, the mRNA and protein expression levels of Prx II were determined using reverse transcrip...
Source: Oncology Letters - September 16, 2018 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research