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Total 981 results found since Jan 2013.

Molecules, Vol. 24, Pages 1429: Primary Step Towards In Situ Detection of Chemical Biomarkers in the UNIVERSE via Liquid-Based Analytical System: Development of an Automated Online Trapping/Liquid Chromatography System
Geffroy-Rodier The search for biomarkers in our solar system is a fundamental challenge for the space research community. It encompasses major difficulties linked to their very low concentration levels, their ambiguous origins (biotic or abiotic), as well as their diversity and complexity. Even if, in 40 years’ time, great improvements in sample pre-treatment, chromatographic separation and mass spectrometry detection have been achieved, there is still a need for new in situ scientific instrumentation. This work presents an original liquid chromatographic system with a trapping unit dedicated to the one-...
Source: Molecules - April 10, 2019 Category: Chemistry Authors: Thomas Ribette Bertrand Leroux Balkis Eddhif Audrey Allavena Marc David Robert Sternberg Pauline Poinot Claude Geffroy-Rodier Tags: Article Source Type: research

Molecules, Vol. 24, Pages 1420: In Vitro Effects on Thrombin of Paris Saponins and In Vivo Hemostatic Activity Evaluation of Paris fargesii var. brevipetala
Hao Zhang The resource shortage of Rhizoma Paridis has never been effectively addressed, and the industry continues to search for alternative resources. The in vitro effects on thrombin of Paris saponins and in vivo hemostatic activity of Paris fargesii var. brevipetala (PF) were evaluated in this study. PF is considered to be an alternative source of Rhizoma Paridis (RP). The in vitro incubation experiment was designed to investigate the effects on thrombin activity of Paris saponin H (PS H) and saponin extract in PF. The bleeding time of mouse tail snipping was used to evaluate the in vivo hemostatic effects of Paris...
Source: Molecules - April 10, 2019 Category: Chemistry Authors: Feiyan Wen Tiezhu Chen Hongxiang Yin Juan Lin Hao Zhang Tags: Article Source Type: research

Molecules, Vol. 24, Pages 1476: In Silico Evaluation of Ibuprofen and Two Benzoylpropionic Acid Derivatives with Potential Anti-Inflammatory Activity
leydson B. R. Santos Inflammation is a complex reaction involving cellular and molecular components and an unspecific response to a specific aggression. The use of scientific and technological innovations as a research tool combining multidisciplinary knowledge in informatics, biotechnology, chemistry and biology are essential for optimizing time and reducing costs in the drug design. Thus, the integration of these in silico techniques makes it possible to search for new anti-inflammatory drugs with better pharmacokinetic and toxicological profiles compared to commercially used drugs. This in silico study evaluated the...
Source: Molecules - April 14, 2019 Category: Chemistry Authors: Jos é A. H. M. Bittencourt Moys és F. A. Neto Pedro S. Lacerda Renata C. V. S. Bittencourt Rai C. Silva Cleison C. Lobato Luciane B. Silva Franco H. A. Leite Juliana P. Zuliani Joaqu ín M. C. Rosa Rosivaldo S. Borges Cleydson B. R. Santos Tags: Article Source Type: research

Molecules, Vol. 24, Pages 1722: Protective Effects of a New C-Jun N-terminal Kinase Inhibitor in the Model of Global Cerebral Ischemia in Rats
The objective of the present work was to study the neuroprotective activity of a new specific JNK inhibitor, IQ-1S (11H-indeno[1,2-b]quinoxalin-11-one oxime sodium salt), in the model of global cerebral ischemia (GCI) in rats compared with citicoline (cytidine-5′-diphosphocholine), a drug approved for the treatment of acute ischemic stroke and to search for pleiotropic mechanisms of neuroprotective effects of IQ-1S. The experiments were performed in a rat model of ischemic stroke with three-vessel occlusion (model of 3VO) affecting the brachiocephalic artery, the left subclavian artery, and the left common ca...
Source: Molecules - May 2, 2019 Category: Chemistry Authors: Mark B. Plotnikov Galina A. Chernysheva Oleg I. Aliev Vera I. Smol ’iakova Tatiana I. Fomina Anton N. Osipenko Victoria S. Rydchenko Yana J. Anfinogenova Andrei I. Khlebnikov Igor A. Schepetkin Dmitriy N. Atochin Tags: Article Source Type: research

Molecules, Vol. 24, Pages 1740: New Quinolone-Based Thiosemicarbazones Showing Activity Against Plasmodium falciparum and Mycobacterium tuberculosis
This study highlights quinolone-thiosemicarabazones as a class of compounds that can be exploited further in search of novel, safe agents with potent activities against both the causal agents of malaria and tuberculosis.
Source: Molecules - May 3, 2019 Category: Chemistry Authors: Richard M. Beteck Ronnett Seldon Audrey Jordaan Digby F. Warner Heinrich C. Hoppe Dustin Laming Setshaba D. Khanye Tags: Article Source Type: research

Molecules, Vol. 24, Pages 1846: Insulin Release Mechanism Modulated by Toxins Isolated from Animal Venoms: From Basic Research to Drug Development Prospects
wartz Venom from mammals, amphibians, snakes, arachnids, sea anemones and insects provides diverse sources of peptides with different potential medical applications. Several of these peptides have already been converted into drugs and some are still in the clinical phase. Diabetes type 2 is one of the diseases with the highest mortality rate worldwide, requiring specific attention. Diverse drugs are available (e.g., Sulfonylureas) for effective treatment, but with several adverse secondary effects, most of them related to the low specificity of these compounds to the target. In this context, the search for specific and...
Source: Molecules - May 13, 2019 Category: Chemistry Authors: Beatriz Elena Sarmiento Luis Felipe Santos Menezes Elisabeth F. Schwartz Tags: Review Source Type: research

Molecules, Vol. 24, Pages 1868: Synthesis and Cytotoxic Evaluation of 3-Methylidenechroman-4-ones
sz Janecki In the search for new anticancer agents, a library of variously substituted 3-methylidenechroman-4-ones was synthesized using Horner–Wadsworth–Emmons methodology. Acylation of diethyl methylphosphonate with selected ethyl salicylates furnished 3-diethoxyphosphorylchromen-4-ones which were next used as Michael acceptors in the reaction with various Grignard reagents. The adducts were obtained as the mixtures of trans and cis diastereoisomers along with a small amount of enol forms. Their relative configuration and preferred conformation were established by NMR analysis. The adducts...
Source: Molecules - May 14, 2019 Category: Chemistry Authors: Jacek K ędzia Tomasz Bartosik Joanna Drogosz Anna Janecka Urszula Krajewska Tomasz Janecki Tags: Article Source Type: research

Molecules, Vol. 24, Pages 1943: High Resolution Mass Profile of Bufadienolides and Peptides Combing with Anti-Tumor Cell Screening and Multivariate Analysis for the Quality Evaluation of Bufonis Venenum
Luo Di Wu Duan In order to evaluate the quality of Bufonis Venenum commercial herbs, a three-step qualitative and quantitative research study was performed. Firstly, we tried to identify small molecules and peptides in Bufonis Venenum using pre-fractionation chromatography and high-resolution mass spectrometry. The database search of the small molecules and peptides of Bufonis Venenum revealed that the dried venom consisted of free/conjugated-type bufadienolides and peptides with a mass range of 0.4–2 kDa. Secondly, we used partial least squares (PLS) multivariate statistical analysis to screen ...
Source: Molecules - May 19, 2019 Category: Chemistry Authors: He Ma Zhou Zhu Lv Li Wang Yan Luo Di Wu Duan Tags: Article Source Type: research

Molecules, Vol. 24, Pages 1975: Synthesis, Biological Evaluation, and In Silico Studies of Novel Aminated Xanthones as Potential p53-Activating Agents
araiva Sousa Xanthone scaffold has been regarded as an attractive chemical tool in the search for bioactive molecules with antitumor activity, and in particular two xanthone derivatives, 12-hydroxy-2,2-dimethyl-3,4-dihydro-2H,6H-pyrano [3,2-b]xanthen-6-one (4) and 3,4-dimethoxy-9-oxo-9H-xanthene-1-carbaldehyde (5), were described as a murine double minute 2 (MDM2)-p53 inhibitor and a TAp73 activator, respectively. The xanthone 5 was used as a starting point for the construction of a library of 3,4-dioxygenated xanthones bearing chemical moieties of described MDM2-p53 inhibitors. Eleven aminated xanthones were succes...
Source: Molecules - May 21, 2019 Category: Chemistry Authors: Lemos Gomes Loureiro Brand ão Palmeira Pinto Saraiva Sousa Tags: Article Source Type: research

Molecules, Vol. 24, Pages 2062: The Multiple Faces of C-Reactive Protein —Physiological and Pathophysiological Implications in Cardiovascular Disease
Molecules, Vol. 24, Pages 2062: The Multiple Faces of C-Reactive Protein—Physiological and Pathophysiological Implications in Cardiovascular Disease Molecules doi: 10.3390/molecules24112062 Authors: Magdalena Boncler Yi Wu Cezary Watala C-reactive protein (CRP) is an intriguing protein which plays a variety of roles in either physiological or pathophysiological states. For years it has been regarded merely as a useful biomarker of infection, tissue injury and inflammation, and it was only in the early 80s that the modified isoforms (mCRP) of native CRP (nCRP) appeared. It soon became clear that the roles of n...
Source: Molecules - May 29, 2019 Category: Chemistry Authors: Magdalena Boncler Yi Wu Cezary Watala Tags: Review Source Type: research

Molecules, Vol. 24, Pages 2077: Sarconesin II, a New Antimicrobial Peptide Isolated from Sarconesiopsis magellanica Excretions and Secretions
This study aims to identify and characterize a new S. magellanica AMP. RP-HPLC was used to fractionate ES, using C18 columns, and their antimicrobial activity was evaluated. The peptide sequence of the fraction collected at 43.7 min was determined by mass spectrometry (MS). Fluorescence and electronic microscopy were used to evaluate the mechanism of action. Toxicity was tested on HeLa cells and human erythrocytes; physicochemical properties were evaluated. The molecule in the ES was characterized as sarconesin II and it showed activity against Gram-negative (Escherichia coli MG1655, Pseudomonas aeruginosa ATCC 27853, P. a...
Source: Molecules - May 30, 2019 Category: Chemistry Authors: Andrea D íaz-Roa Abraham Espinoza-Culup ú Orlando Torres-Garc ía Monamaris M. Borges Ivan N. Avino Fl ávio L. Alves Antonio Miranda Manuel A. Patarroyo Pedro I. da Silva Felio J. Bello Tags: Article Source Type: research

Molecules, Vol. 24, Pages 2172: Avocado Oil: Characteristics, Properties, and Applications
tiz-Viedma Avocado oil has generated growing interest among consumers due to its nutritional and technological characteristics, which is evidenced by an increase in the number of scientific articles that have been published on it. The purpose of the present research was to discuss the extraction methods, chemical composition, and various applications of avocado oil in the food and medicine industries. Our research was carried out through a systematic search in scientific databases. Even though there are no international regulations concerning the quality of avocado oil, some authors refer to the parameters used for oli...
Source: Molecules - June 9, 2019 Category: Chemistry Authors: Marcos Flores Carolina Saravia Claudia E. Vergara Felipe Avila Hugo Vald és Jaime Ortiz-Viedma Tags: Review Source Type: research

Molecules, Vol. 24, Pages 2223: Identification of a Heat-Inducible Element of Cysteine Desulfurase Gene Promoter in Lentinula edodes
In this study, the promoter sequence of the cysteine desulfurase gene (pCS) was cloned and analyzed using bioinformatics tools. A series of 5′deletion fragments and site-directed mutations of pCS were constructed to identify the element that responds to heat stress. Six heat shock transcription factor (HSTF) binding sites were predicted by SCPD (The Promoter Database of Saccharomyces cerevisiae) and three of the binding sites were predicted by Yeastract (Yeast Search for Transcriptional Regulators and Consensus Tracking) in pCS. The results indicated that pCS was able to drive the expression of the EGFP (Enha...
Source: Molecules - June 13, 2019 Category: Chemistry Authors: Zhicheng Huang Xiaoyu Lei Xi Feng Shuangshuang Gao Gangzheng Wang Yinbing Bian Wen Huang Ying Liu Tags: Article Source Type: research

Molecules, Vol. 24, Pages 2272: Symphytum Species: A Comprehensive Review on Chemical Composition, Food Applications and Phytopharmacology
d Valere Tsouh Fokou Cho Martins Symphytum species belongs to the Boraginaceae family and have been used for centuries for bone breakages, sprains and rheumatism, liver problems, gastritis, ulcers, skin problems, joint pain and contusions, wounds, gout, hematomas and thrombophlebitis. Considering the innumerable potentialities of the Symphytum species and their widespread use in the world, it is extremely important to provide data compiling the available literature to identify the areas of intense research and the main gaps in order to design future studies. The present review aims at summarizing the main data...
Source: Molecules - June 17, 2019 Category: Chemistry Authors: Salehi Sharopov Boyunegmez Tumer Ozleyen Rodr íguez‐Pérez Ezzat Azzini Hosseinabadi Butnariu Sarac Bostan Acharya Sen Nur Kasapoglu Da şkaya-Dikmen Özçelik Baghalpour Sharifi-Rad Valere Tsouh Fokou Cho Martins Tags: Review Source Type: research

Molecules, Vol. 24, Pages 2321: Discovery of Novel UV-Filters with Favorable Safety Profiles in the 5-Arylideneimidazolidine-2,4-dione Derivatives Group
k Marona Elżbieta Pękala Effective protection from the harmful effects of UV radiation may be achieved by using sunscreens containing organic or inorganic UV filters. The number of currently available UV filters is limited and some of the allowed molecules possess limitations such as systemic absorption, endocrine disruption properties, contact and photocontact allergy induction, and low photostability. In the search for new organic UV filters we designed and synthesized a series consisting of 5-benzylidene and 5-(3-phenylprop-2-en-1-ylidene)imidazolidine-2,4-dione (hydantoin) derivatives. The photoprotective activ...
Source: Molecules - June 23, 2019 Category: Chemistry Authors: Justyna Popi ół Agnieszka Gunia-Krzy żak Kamil Piska Dorota Żelaszczyk Paulina Koczurkiewicz Karolina S łoczyńska Katarzyna W ójcik-Pszczoła Anna Krupa Agata Kryczyk-Poprawa Ewa Żesławska Wojciech Nitek Pawe ł Żmudzki Henryk Marona El żbieta Tags: Article Source Type: research