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Total 992 results found since Jan 2013.

Molecules, Vol. 28, Pages 4199: Trisubstituted 1,3,5-triazines as Histamine H4 Receptor Antagonists with Promising Activity In Vivo
Dorota Łażewska Pain is a very unpleasant experience that makes life extremely uncomfortable. The histamine H4 receptor (H4R) is a promising target for the treatment of inflammatory and immune diseases, as well as pain. H4R ligands have demonstrated analgesic effects in a variety of pain models, including inflammatory pain. Continuing the search for active H4R ligands among the alkyl derivatives of 1,3,5-triazine, we obtained 19 new compounds in two series: acyclic (I) and aliphatic (II). In vitro pharmacological evaluation showed their variable affinity for H4R. The majority of compounds showed a moderate affinity ...
Source: Molecules - May 19, 2023 Category: Chemistry Authors: Agnieszka Olejarz-Maciej Szczepan Mogilski Tadeusz Karcz Tobias Werner Katarzyna Kami ńska Jaros ław Kupczyk Ewelina Honkisz-Orzechowska Gniewomir Latacz Holger Stark Katarzyna Kie ć-Kononowicz Dorota Łażewska Tags: Article Source Type: research

Molecules, Vol. 28, Pages 4184: Chemical Profile, Antibacterial, Antibiofilm, and Antiviral Activities of Pulicaria crispa Most Potent Fraction: An In Vitro and In Silico Study
lal El Menofy Infectious diseases caused by viruses and bacteria are a major public health concern worldwide, with the emergence of antibiotic resistance, biofilm-forming bacteria, viral epidemics, and the lack of effective antibacterial and antiviral agents exacerbating the problem. In an effort to search for new antimicrobial agents, this study aimed to screen antibacterial and antiviral activity of the total methanol extract and its various fractions of Pulicaria crispa (P. crispa) aerial parts. The P. crispa hexane fraction (HF) was found to have the strongest antibacterial effect against both Gram-positive and Gra...
Source: Molecules - May 19, 2023 Category: Chemistry Authors: Fatma Abo-Elghiet Areej Rushdi Mona H. Ibrahim Sara H. Mahmoud Mohamed A. Rabeh Saad Ali Alshehri Nagwan Galal El Menofy Tags: Article Source Type: research

Molecules, Vol. 28, Pages 4181: Characterization of the Nonpolar and Polar Extractable Components of Glanded Cottonseed for Its Valorization
Qi Zhao Cottonseed is the second major product of cotton (Gossypium spp.) crops after fiber. Thus, the characterization and valorization of cottonseed are important parts of cotton utilization research. In this work, the nonpolar and polar fractions of glanded (Gd) cottonseed were sequentially extracted by 100% hexane and 80% ethanol aqueous solutions and subjected to 13C and 1H nuclear magnetic resonance (NMR) spectroscopy and Fourier-transform ion cyclotron resonance mass spectrometry (FT-ICR MS), respectively. The nonpolar (crude oil) extracts showed the characteristic NMR peak features of edible plant oils with the...
Source: Molecules - May 19, 2023 Category: Chemistry Authors: Zhongqi He Sunghyun Nam Shasha Liu Qi Zhao Tags: Article Source Type: research

Molecules, Vol. 28, Pages 4124: Highly Flexible Poly(1,12-dodecylene 5,5 & prime;-isopropylidene-bis(ethyl 2-furoate)): A Promising Biobased Polyester Derived from a Renewable Cost-Effective Bisfuranic Precursor and a Long-Chain Aliphatic Spacer
Molecules, Vol. 28, Pages 4124: Highly Flexible Poly(1,12-dodecylene 5,5′-isopropylidene-bis(ethyl 2-furoate)): A Promising Biobased Polyester Derived from a Renewable Cost-Effective Bisfuranic Precursor and a Long-Chain Aliphatic Spacer Molecules doi: 10.3390/molecules28104124 Authors: Sami Zaidi Abdelkader Bougarech Majdi Abid Souhir Abid Armando J. D. Silvestre Andreia F. Sousa The continuous search for novel biobased polymers with high-performance properties has highlighted the role of monofuranic-based polyesters as some of the most promising for future plastic industry but has neglected th...
Source: Molecules - May 16, 2023 Category: Chemistry Authors: Sami Zaidi Abdelkader Bougarech Majdi Abid Souhir Abid Armando J. D. Silvestre Andreia F. Sousa Tags: Article Source Type: research

Molecules, Vol. 28, Pages 4101: Investigation of Polyphenolic Compounds in Different Varieties of Black Chokeberry Aronia melanocarpa
V. Ramenskaya The purpose of this work was to study the qualitative and quantitative composition of the main groups of biologically active substances in the fresh fruits of five different varieties of black chokeberry (Aronia melanocarpa (Michx.) Elliot), carried out within the framework of the search for available and cost-effective raw materials for food product fortification. Samples of aronia chokeberry were grown at the Federal Scientific Center named after I.V. Michurin in the Tambov region of Russia. Using a modern chemical–analytical methodology, the contents and profiles of anthocyanin pigments, ...
Source: Molecules - May 15, 2023 Category: Chemistry Authors: Makar A. Gerasimov Irina B. Perova Konstantin I. Eller Michail Y. Akimov Anna M. Sukhanova Galina M. Rodionova Galina V. Ramenskaya Tags: Article Source Type: research

Molecules, Vol. 28, Pages 4100: Bioinformatic Analysis of Key Regulatory Genes in Adult Asthma and Prediction of Potential Drug Candidates
Lihua Zhang Asthma is a common chronic disease that is characterized by respiratory symptoms including cough, wheeze, shortness of breath, and chest tightness. The underlying mechanisms of this disease are not fully elucidated, so more research is needed to identify better therapeutic compounds and biomarkers to improve disease outcomes. In this present study, we used bioinformatics to analyze the gene expression of adult asthma in publicly available microarray datasets to identify putative therapeutic molecules for this disease. We first compared gene expression in healthy volunteers and adult asthma patients to obtai...
Source: Molecules - May 15, 2023 Category: Chemistry Authors: Shaojun Chen Jiahao Lv Yiyuan Luo Hongjiang Chen Shuwei Ma Lihua Zhang Tags: Article Source Type: research

Molecules, Vol. 28, Pages 4073: The Chemical Space of Marine Antibacterials: Diphenyl Ethers, Benzophenones, Xanthones, and Anthraquinones
M. Afonso The emergence of multiresistant bacteria and the shortage of antibacterials in the drug pipeline creates the need to search for novel agents. Evolution drives the optimization of the structure of marine natural products to act as antibacterial agents. Polyketides are a vast and structurally diverse family of compounds that have been isolated from different marine microorganisms. Within the different polyketides, benzophenones, diphenyl ethers, anthraquinones, and xanthones have shown promising antibacterial activity. In this work, a dataset of 246 marine polyketides has been identified. In order to characteri...
Source: Molecules - May 13, 2023 Category: Chemistry Authors: Jos é X. Soares In ês Afonso Adaleta Omerbasic Daniela R. P. Loureiro Madalena M. M. Pinto Carlos M. M. Afonso Tags: Article Source Type: research

Molecules, Vol. 28, Pages 4044: Pharmacophore-Based Virtual Screening and In-Silico Explorations of Biomolecules (Curcumin Derivatives) of Curcuma longa as Potential Lead Inhibitors of ERBB and VEGFR-2 for the Treatment of Colorectal Cancer
jad Bilal The newly FDA-approved drug, Axitinib, is an effective therapy against RTKs, but it possesses severe adverse effects like hypertension, stomatitis, and dose-dependent toxicity. In order to ameliorate Axitinib’s downsides, the current study is expedited to search for energetically stable and optimized pharmacophore features of 14 curcumin (1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione) derivatives. The rationale behind the selection of curcumin derivatives is their reported anti-angiogenic and anti-cancer properties. Furthermore, they possessed a low molecular weight and a low toxic...
Source: Molecules - May 12, 2023 Category: Chemistry Authors: Syeda Abida Ejaz Mubashir Aziz Mohamed Fawzy Ramadan Ammara Fayyaz Muhammad Sajjad Bilal Tags: Article Source Type: research

Molecules, Vol. 28, Pages 4015: Analogy of the Reactions of Aromatic and Aliphatic & pi;-Electrophiles with Nucleophiles
Molecules, Vol. 28, Pages 4015: Analogy of the Reactions of Aromatic and Aliphatic π-Electrophiles with Nucleophiles Molecules doi: 10.3390/molecules28104015 Authors: Michał Barbasiewicz Michał Fedoryński Rafał Loska Mieczysław Mąkosza The aim of this essay is to disclose the similarity of a great variety of reactions that proceed between nucleophiles and π-electrophiles—both aromatic and aliphatic. These reactions proceed via initial reversible addition, followed by a variety of transformations that are common for the adducts of both aliphatic and aromatic electrophiles....
Source: Molecules - May 11, 2023 Category: Chemistry Authors: Micha ł Barbasiewicz Micha ł Fedoryński Rafa ł Loska Mieczys ław Mąkosza Tags: Review Source Type: research

Molecules, Vol. 28, Pages 4035: Hybrid Nanocomposites of Tenoxicam: Layered Double Hydroxides (LDHs) vs. Hydroxyapatite (HAP) Inorganic Carriers
ella Bini The search for effective systems to facilitate the release of poorly bioavailable drugs is a forefront topic for the pharmaceutical market. Materials constituted by inorganic matrices and drugs represent one of the latest research strategies in the development of new drug alternatives. Our aim was to obtain hybrid nanocomposites of Tenoxicam, an insoluble nonsteroidal anti-inflammatory drug, with both layered double hydroxides (LDHs) and hydroxyapatite (HAP). The physicochemical characterization on the base of X-ray powder diffraction, SEM/EDS, DSC and FT-IR measurements was useful to verify the possible hybr...
Source: Molecules - May 11, 2023 Category: Chemistry Authors: Lauretta Maggi Valeria Friuli Giovanna Bruni Alessia Rinaldi Marcella Bini Tags: Article Source Type: research

Molecules, Vol. 28, Pages 3973: Aroma Characterization of Roasted Meat and Meat Substitutes Using Gas Chromatography & ndash;Mass Spectrometry with Simultaneous Selective Detection and a Dedicated Software Tool, AromaMS
Molecules, Vol. 28, Pages 3973: Aroma Characterization of Roasted Meat and Meat Substitutes Using Gas Chromatography–Mass Spectrometry with Simultaneous Selective Detection and a Dedicated Software Tool, AromaMS Molecules doi: 10.3390/molecules28093973 Authors: Nitzan Tzanani Ariel Hindi Dana Marder The development of healthier and more sustainable food products, such as plant-based meat substitutes (PBMSs), have received significant interest in recent years. A thorough understanding of the aroma composition can support efforts to improve the sensory properties of PBMS products and promote their consu...
Source: Molecules - May 8, 2023 Category: Chemistry Authors: Nitzan Tzanani Ariel Hindi Dana Marder Tags: Article Source Type: research

Molecules, Vol. 28, Pages 3959: Cytotoxic Activity, Topoisomerase I Inhibition and In Silico Studies of New Sesquiterpene-aryl Ester Derivatives of (-) Drimenol
In this study, we aimed to evaluate two sets of sesquiterpene-aryl derivatives linked by an ester bond, their cytotoxic activities, and their capacity to activate caspases 3/7 and inhibit human topoisomerase I (TOP1). A total of 13 compounds were synthesized from the natural sesquiterpene (-)-drimenol and their cytotoxic activity was evaluated in vitro against three cancer cell lines: PC-3 (prostate cancer), HT-29 (colon cancer), MCF-7 (breast cancer), and an immortalized non-tumoral cell line (MCF-10). From the results, it was observed that 6a was the most promising compound due to its cytotoxic effect on three cancer cel...
Source: Molecules - May 8, 2023 Category: Chemistry Authors: Ileana Araque Javiera Ram írez Rut Vergara Jaime Mella Pablo Ar ánguiz Luis Espinoza Waleska Vera Iv án Montenegro Cristian O. Salas Joan Villena Mauricio A. Cuellar Tags: Article Source Type: research

Molecules, Vol. 28, Pages 3938: Identification of Small Molecule Inhibitors of Human Cytomegalovirus pUL89 Endonuclease Using Integrated Computational Approaches
This study provided promising starting point for further in vitro and in vivo studies.
Source: Molecules - May 7, 2023 Category: Chemistry Authors: Mazen Almehmadi Ihtisham Ul Haq Ahad Amer Alsaiari Fahad M. Alshabrmi Osama Abdulaziz Mamdouh Allahyani Mohammed Aladhadh Alaa Shafie Abdulelah Aljuaid Rema Turki Alotaibi Jawad Ullah Nada Saud Alharthi Tags: Article Source Type: research

Molecules, Vol. 28, Pages 3931: Comparative Analysis of Stable Gold Nanoparticles Synthesized Using Sonochemical and Reduction Methods for Antibacterial Activity
This study focuses on the influence of synthetic methods on the aggregation stability and antibacterial activity of gold nanoparticles (NPs) prepared by using sodium citrate as a reducing and capping agent against Staphylococcus aureus (S. aureus). Gold NPs were synthesized using a simple and rapid sonochemical method and compared to gold NPs synthesized using a reduction method. The physicochemical features of gold NPs were characterized using UV-vis, XRD, TEM, and zeta potential, and the TEM results showed that the sonochemical method produced monodispersed spherical gold NPs with an average diameter of 18.5 nm, while th...
Source: Molecules - May 6, 2023 Category: Chemistry Authors: Mohammed Ali Dheyab Azlan Abdul Aziz Nazila Oladzadabbasabadi Alyaa Alsaedi Farhank Saber Braim Mahmood S. Jameel Asmeit Ramizy Mohammad Alrosan Ali Madi Almajwal Tags: Article Source Type: research

Molecules, Vol. 28, Pages 3809: Acetogenins-Rich Fractions of Annona coriacea Suppress Human Glioblastoma Viability and Migration by Regulating Necroptosis and MMP-2 Activity In Vitro
. M. A. Ribeiro Glioblastoma (GBM) is an incurable primary brain tumor with a poor prognosis. Resection, radiation therapy, and temozolomide (TMZ) are insufficient to increase survival, making the treatment limited. Thus, the search for more effective and specific treatments is essential, making plants a promising source for elucidating new anti-glioblastoma compounds. Accordingly, this study investigated the effects of four fractions of hexane and ethyl acetate extract of Annona coriacea Mart., enriched with acetogenins, against GBM cell lines. All four fractions were selectively cytotoxic to GBM cells when compared t...
Source: Molecules - April 29, 2023 Category: Chemistry Authors: Lorena R. Sousa Ana Gabriela S. Oliveira Ant ônio Arantes Jo ão Gabriel M. Junqueira Gerso P. Alexandre Vanessa G. P. Severino Rui Manuel Reis Bonglee Kim Rosy I. M. A. Ribeiro Tags: Article Source Type: research