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Specialty: Genetics & Stem Cells
Source: Genes

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Total 55 results found since Jan 2013.

Genes, Vol. 13, Pages 48: Ischemic Stroke Genetics: What Is New and How to Apply It in Clinical Practice?
Jatužis The etiology of ischemic stroke is multifactorial. Although receiving less emphasis, genetic causes make a significant contribution to ischemic stroke genesis, especially in early-onset stroke. Several stroke classification systems based on genetic information corresponding to various stroke phenotypes were proposed. Twin and family history studies, as well as candidate gene approach, are common methods to discover genetic causes of stroke, however, both have their own limitations. Genome-wide association studies and next generation sequencing are more efficient, promising and increasingly used for daily diagn...
Source: Genes - December 24, 2021 Category: Genetics & Stem Cells Authors: Aleksandra Ekkert Aleksandra Šliachtenko Julija Grigait ė Birut ė Burnytė Algirdas Utkus Dalius Jatu žis Tags: Review Source Type: research

Genes, Vol. 12, Pages 1860: MicroRNA Analysis of Human Stroke Brain Tissue Resected during Decompressive Craniectomy/Stroke-Ectomy Surgery
Conclusions: Dysregulated miRNAs detected in our study could be regarded as potential candidates for biomarkers and/or targets for therapeutic intervention. The results described herein further our understanding of the molecular basis of stroke and provide valuable information for the future functional studies in the experimental models of stroke.
Source: Genes - November 23, 2021 Category: Genetics & Stem Cells Authors: Andrew P. Carlson William McKay Jeremy S. Edwards Radha Swaminathan Karen S. SantaCruz Ron L. Mims Howard Yonas Tamara Roitbak Tags: Article Source Type: research

Genes, Vol. 11, Pages 726: Transcriptome Analysis of Skeletal Muscle Reveals Altered Proteolytic and Neuromuscular Junction Associated Gene Expressions in a Mouse Model of Cerebral Ischemic Stroke
S. Mohamed Stroke is a leading cause of mortality and long-term disability in patients worldwide. Skeletal muscle is the primary systemic target organ of stroke that induces muscle wasting and weakness, which predominantly contribute to functional disability in stroke patients. Currently, no pharmacological drug is available to treat post-stroke muscle morbidities as the mechanisms underlying post-stroke muscle wasting remain poorly understood. To understand the stroke-mediated molecular changes occurring at the transcriptional level in skeletal muscle, the gene expression profiles and enrichment pathways were explore...
Source: Genes - June 29, 2020 Category: Genetics & Stem Cells Authors: Peter J. Ferrandi Mohammad Moshahid Khan Hector G. Paez Christopher R. Pitzer Stephen E. Alway Junaith S. Mohamed Tags: Article Source Type: research

Genes, Vol. 13, Pages 978: Stroke and Etiopathogenesis: What Is Known?
Conclusion: We summarize the latest evidence and perspectives of ischemic stroke genetics that may be of interest to the physician and useful for day-to-day clinical work in terms of both prevention and treatment of ischemic stroke.
Source: Genes - May 30, 2022 Category: Genetics & Stem Cells Authors: Tiziana Ciarambino Pietro Crispino Erika Mastrolorenzo Antonello Viceconti Mauro Giordano Tags: Review Source Type: research

Genes, Vol. 12, Pages 1825: Genetic and Genomic Epidemiology of Stroke in People of African Ancestry
cinth Stroke is one of the leading causes of disability and death worldwide and places a significant burden on healthcare systems. There are significant racial/ethnic differences in the incidence, subtype, and prognosis of stroke, between people of European and African ancestry, of which only about 50% can be explained by traditional stroke risk facts. However, only a small number of genetic studies include individuals of African descent, leaving many gaps in our understanding of stroke genetics among this population. This review article highlights the need for and significance of including African-ancestry individuals...
Source: Genes - November 19, 2021 Category: Genetics & Stem Cells Authors: Savvina Prapiadou Stacie L. Demel Hyacinth I. Hyacinth Tags: Review Source Type: research

Genes, Vol. 14, Pages 61: Exome Array Analysis of 9721 Ischemic Stroke Cases from the SiGN Consortium
James Perry Charles Hong John Cole Elizabeth Pugh Kimberly Doheny Sharon Kardia David Weir Steven Kittner Braxton Consortium Recent genome wide association studies have identified 89 common genetic variants robustly associated with ischemic stroke and primarily located in non-coding regions. To evaluate the contribution of coding variants, which are mostly rare, we performed an exome array analysis on 106,101 SNPs for 9721 ischemic stroke cases from the SiGN Consortium, and 12,345 subjects with no history of stroke from the Health Retirement Study and SiGN consortium. We identified 15 coding variants si...
Source: Genes - December 24, 2022 Category: Genetics & Stem Cells Authors: Huichun Xu Kevin Nguyen Brady Gaynor Hua Ling Wei Zhao Patrick McArdle Timothy O ’Connor O. Stine Kathleen Ryan Megan Lynch Jennifer Smith Jessica Faul Yao Hu Jeffrey Haessler Myriam Fornage Charles Kooperberg On Group James Perry Charles Hong John Cole Tags: Article Source Type: research

Genes, Vol. 8, Pages 89: Epigenetics in Stroke Recovery
Abstract: While the death rate from stroke has continually decreased due to interventions in the hyperacute stage of the disease, long-term disability and institutionalization have become common sequelae in the aftermath of stroke. Therefore, identification of new molecular pathways that could be targeted to improve neurological recovery among survivors of stroke is crucial. Epigenetic mechanisms such as post-translational modifications of histone proteins and microRNAs have recently emerged as key regulators of the enhanced plasticity observed during repair processes after stroke. In this review, we highlight the recent a...
Source: Genes - February 26, 2017 Category: Genetics & Stem Cells Authors: Haifa Kassis Amjad Shehadah Michael Chopp Zheng Zhang Tags: Review Source Type: research

Genes, Vol. 13, Pages 144: Influence of Haptoglobin Polymorphism on Stroke in Sickle Cell Disease Patients
vain Doré This review outlines the current clinical research investigating how the haptoglobin (Hp) genetic polymorphism and stroke occurrence are implicated in sickle cell disease (SCD) pathophysiology. Hp is a blood serum glycoprotein responsible for binding and removing toxic free hemoglobin from the vasculature. The role of Hp in patients with SCD is critical in combating blood toxicity, inflammation, oxidative stress, and even stroke. Ischemic stroke occurs when a blocked vessel decreases oxygen delivery in the blood to cerebral tissue and is commonly associated with SCD. Due to the malformed red blood cells of s...
Source: Genes - January 14, 2022 Category: Genetics & Stem Cells Authors: Olivia Edwards Alicia Burris Josh Lua Diana J. Wilkie Miriam O. Ezenwa Sylvain Dor é Tags: Review Source Type: research

Genes, Vol. 14, Pages 953: Neuroprotective Peptides and New Strategies for Ischemic Stroke Drug Discoveries
asoedov Ischemic stroke continues to be one of the leading causes of death and disability in the adult population worldwide. The currently used pharmacological methods for the treatment of ischemic stroke are not effective enough and require the search for new tools and approaches to identify therapeutic targets and potential neuroprotectors. Today, in the development of neuroprotective drugs for the treatment of stroke, special attention is paid to peptides. Namely, peptide action is aimed at blocking the cascade of pathological processes caused by a decrease in blood flow to the brain tissues. Different groups of pep...
Source: Genes - April 22, 2023 Category: Genetics & Stem Cells Authors: Lyudmila V. Dergunova Ivan B. Filippenkov Svetlana A. Limborska Nikolay F. Myasoedov Tags: Review Source Type: research

Genes, Vol. 12, Pages 579: Association Study of SLC6A4 (5-HTTLPR) Polymorphism and Its Promoter Methylation with Rehabilitation Outcome in Patients with Subacute Stroke
rene Aprile Recently it has been suggested that serotonin transporter (SLC6A4) and its 5HTTLPR polymorphism could be involved in post stroke recovery. Here, we characterized the methylation profile of two different CpG islands within the SLC6A4 promoter region in the whole blood of 50 patients with subacute stroke before and after a six-week rehabilitation treatment. These patients were genotyped for 5HTTLPR polymorphism identifying patients on the basis of short (S) and L (L) alleles: 17 patients LL, 22 patients LS and 11 patients SS. At baseline, all CpG sites for both CpG islands displayed a heterogeneous methylatio...
Source: Genes - April 16, 2021 Category: Genetics & Stem Cells Authors: Massimo Santoro Mariacristina Siotto Marco Germanotta Alessia Mastrorosa Dionysia Papadopoulou Irene Aprile Tags: Article Source Type: research

Genes, Vol. 12, Pages 787: Network Protein Interaction in the link between Stroke and Periodontitis Interplay: A Pilot Bioinformatic Analysis
ado Botelho The clinical interaction between stroke and periodontitis has been consistently studied and confirmed. Hence, exploring potentially new protein interactions in this association using bioinformatic strategies presents potential interest. In this exploratory study, we conducted a protein–protein network interaction (PPI) search with documented encoded proteins for both stroke and periodontitis. Genes of interest were collected via GWAS database. The STRING database was used to predict the PPI networks, first in a sensitivity purpose (confidence cut-off of 0.7), and then with a highest confidence cut-off ...
Source: Genes - May 20, 2021 Category: Genetics & Stem Cells Authors: Leira Mascarenhas Blanco Sobrino Mendes Machado Botelho Tags: Article Source Type: research

Genes, Vol. 13, Pages 2204: Proteomic Markers in the Muscles and Brain of Pigs Recovered from Hemorrhagic Stroke
Conclusions: A network of gene interactions has been constructed for proteins involved in the regulation of synaptic transmission, in particular presynaptic vesicular and endocytic processes. The presence of transmitters and transporters associated with stimulation of NMDA receptors at neuromuscular junctions shows the relationship between upper motor neurons and neuromuscular junctions.
Source: Genes - November 24, 2022 Category: Genetics & Stem Cells Authors: Fedulova Vasilevskaya Tikhonova Kazieva Tolmacheva Makarenko Tags: Article Source Type: research

Genes, Vol. 14, Pages 454: Temporal and Spatial Gene Expression Profile of Stroke Recovery Genes in Mice
kus Aswendt Stroke patients show some degree of spontaneous functional recovery, but this is not sufficient to prevent long-term disability. One promising approach is to characterize the dynamics of stroke recovery genes in the lesion and distant areas. We induced sensorimotor cortex lesions in adult C57BL/6J mice using photothrombosis and performed qPCR on selected brain areas at 14, 28, and 56 days post-stroke (P14-56). Based on the grid walk and rotating beam test, the mice were classified into two groups. The expression of cAMP pathway genes Adora2a, Pde10a, and Drd2, was higher in poor- compared to well-recovered ...
Source: Genes - February 9, 2023 Category: Genetics & Stem Cells Authors: Jan G ötz Frederique Wieters Veronika J. Fritz Olivia K äsgen Aref Kalantari Gereon R. Fink Markus Aswendt Tags: Article Source Type: research

Genes, Vol. 14, Pages 1382: Synthetic Adrenocorticotropic Peptides Modulate the Expression Pattern of Immune Genes in Rat Brain following the Early Post-Stroke Period
This study gives insight into how the transcriptome depends on the variation in the structure of the related peptides, and it is valuable from the standpoint of the development of measures for early post-stroke therapy.
Source: Genes - June 30, 2023 Category: Genetics & Stem Cells Authors: Ivan B. Filippenkov Julia A. Remizova Vasily V. Stavchansky Alina E. Denisova Leonid V. Gubsky Nikolay F. Myasoedov Svetlana A. Limborska Lyudmila V. Dergunova Tags: Article Source Type: research

Genes, Vol. 14, Pages 1448: Isoflurane Anesthesia & rsquo;s Impact on Gene Expression Patterns of Rat Brains in an Ischemic Stroke Model
Conclusions: We were able to determine the effects of the duration of anesthesia using isoflurane on the transcriptomes in the brains of rats at 24 h after tMCAO. Thus, specific genome responses may be useful in developing potential approaches to reduce damaged areas after cerebral ischemia and neuroprotection.
Source: Genes - July 14, 2023 Category: Genetics & Stem Cells Authors: Yana Y. Shpetko Ivan B. Filippenkov Alina E. Denisova Vasily V. Stavchansky Leonid V. Gubsky Svetlana A. Limborska Lyudmila V. Dergunova Tags: Article Source Type: research