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Radionuclide Imaging in Ischemic Stroke
Ischemic stroke is caused by interruption or significant impairment of blood supply to the brain, which leads to a cascade of metabolic and molecular alterations resulting in functional disturbance and morphologic damage. The changes in regional cerebral blood flow and regional metabolism can be assessed by radionuclide imaging, especially SPECT and PET. SPECT and PET have broadened our understanding of flow and metabolic thresholds critical for maintenance of brain function and morphology: PET was essential in the transfer of the concept of the penumbra to clinical stroke and thereby had a great impact on developing treat...
Source: Journal of Nuclear Medicine - November 3, 2014 Category: Radiology Authors: Heiss, W.-D. Tags: Continuing Education Source Type: research

In Vivo Quantification of Cerebral Translocator Protein Binding in Humans Using 6-Chloro-2-(4'-123I-Iodophenyl)-3-(N,N-Diethyl)-Imidazo1,2-aPyridine-3-Acetamide SPECT
Conclusion: As demonstrated within a group of stroke and GBM patients, 123I-CLINDE SPECT can be used for quantitative assessment of TSPO expression in vivo. Because of the absence of a region devoid of TSPO, reference tissue models should be used with caution. The 2-tissue-compartment kinetic analysis of a 90-min dynamic scan with arterial blood sampling is recommended for the quantification of 123I-CLINDE binding with SPECT.
Source: Journal of Nuclear Medicine - December 1, 2014 Category: Radiology Authors: Feng, L., Svarer, C., Thomsen, G., de Nijs, R., Larsen, V. A., Jensen, P., Adamsen, D., Dyssegaard, A., Fischer, W., Meden, P., Krieger, D., Moller, K., Knudsen, G. M., Pinborg, L. H. Tags: Clinical Investigations Source Type: research