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Source: Journal of Nuclear Medicine
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Total 81 results found since Jan 2013.
Molecular imaging of inflammation in the brain-heart axis after ischemic stroke: comparison of two murine stroke models.
Conclusions: In contrast to topical ET-1 application after craniotomy, the intravascular MCAo model enables imaging studies of brain-heart networking after stroke, which evokes elevated TSPO PET signal in both brain and heart. The severity of cerebral ischemic damage may contribute to cardiac dysfunction via systemic inflammatory networking.
Source: Journal of Nuclear Medicine - May 14, 2020 Category: Nuclear Medicine Authors: Hermanns, N., Bascunana, P., Langer, B. L. N., Wolf, B., Bankstahl, J., Ross, T., Bengel, F., Thackeray, J. Tags: Cardiovascular Council YIA Symposium Source Type: research
Causal role of non-stenotic hypodense plaques with high FDG uptake detected with PET-CT angiography in patients with unknown cause of stroke?
Conclusions In this exploratory study, we found a high prevalence of non-stenotic hypodense plaques with high FDG uptake (TBR max. > 1.80) in carotid arteries ipsilateral to cerebral ischemia suggesting a causal role for these plaque in patients with unknown cause of stroke. In comparison to high-resolution MRI, the imaging criteria used in this study for the identification of complicated plaques were very simple and easy to implement. In addition, FDG-PET-CTA allows for the evaluation of non-stenotic plaques along the whole length of supra-aortic trunks. Further studies with a larger number of patients are requested to...
Source: Journal of Nuclear Medicine - May 23, 2016 Category: Nuclear Medicine Authors: Mikail, N., Mazighi, M., Meseguer, E., Guidoux, C., Leseche, G., Rouzet, F., Le Guludec, D., Amarenco, P., Hyafil, F. Tags: MTA II: Cardiovascular Clinical Science Posters Source Type: research
Monitoring synaptic loss in a rat model of stroke: a PET imaging study with 18FSynVesT-2, radiotracer for the synaptic vesicle protein 2A (SV2A)
Conclusions: Using [18F]SynVesT-2 and PET imaging, we successfully detected synapse loss in rat MCAO model and tracked disease progression via lesion quantification. Synapse loss is mainly in hippocampus, thalamus, and neocortex, rather than cerebellum. Furthermore, most significant loss of synapses was observed to occur during the first week post reperfusion. Our results showed that the quantification of synaptic density by SV2A PET may provide an objective measure of disease progression and a primary endpoint to evaluate treatment efficacy of novel therapeutics for stroke in clinical trials. References: Bunevicius et al....
Source: Journal of Nuclear Medicine - May 14, 2020 Category: Nuclear Medicine Authors: Lyu, X., Toyonaga, T., Deng, G., Huang, Y., Carson, R., Zhou, J., Cai, Z. Tags: Basic Science - Synaptic activity and other mechanisms Source Type: research
FDG PET Imaging as A Non-invasive Method to Demonstrate Peri-infarct Depression after Stroke
Conclusion: FDG PET imaging is reliable to reflect metabolic stress imposed by peri-infarct depression. Peri-infarct depression leads to the metabolic change in neurons, including suppression of mitochondria function and overactivation of glycolysis, thus deteriorate functional and tissue consequence. The insults from PID could be alleviated by improving mitochondria function.
Source: Journal of Nuclear Medicine - May 23, 2018 Category: Nuclear Medicine Authors: Yao, J., Zhou, R., Shi, J., Zhang, H. Tags: Basic Science III Source Type: research
PET imaging of ischemic brain stroke necrosis with novel agent 18F-Fluoroglucaric Acid
Conclusions: Results show that FGA has a potential to enable extremely sensitive and high resolution neuroimaging of brain infarcts. F-18-labeled FGA can be rapidly synthesized from ubiquitously available F-18-FDG in a simple reaction.
Source: Journal of Nuclear Medicine - May 23, 2018 Category: Nuclear Medicine Authors: Houson, H., Mdzinarishvili, A., Awasthi, V. Tags: Basic Science III Source Type: research
18FDBT10 as alpha7-nAChR ligand to image stroke-associated neuroinflammation by PET
616Objectives: t is known that, after ischemic stroke, neuroinflammatory processes occur which represent interesting treatment targets. However, sufficient in vivo imaging of these processes, particularly in acute and subacute stages, was not possible upon till now. During neuroinflammation, alpha7-nicotinic acetylcholine receptors (nAChRs) are overexpressed. We, thus, tested the novel alpha7-nAChR ligand [18F]DBT10 for its potential to image post-stroke neuroinflammation. In 10 adult Merino sheep, the left middle cerebral artery was permanently occluded (pMCAO, day 1). On day 0 (baseline) as well as 4hrs after pMCAO, and ...
Source: Journal of Nuclear Medicine - May 23, 2018 Category: Nuclear Medicine Authors: Barthel, H., Deuther-Conrad, W., Patt, M., Nitzsche, B., Teodoro, R., Hartig, W., Wenzel, B., Aleithe, S., Mages, B., Luthardt, J., Rullmann, M., Becker, G., Grunwald, T., Michalski, D., Boltze, J., Brust, P., Sabri, O. Tags: Probes for Neuroimaging II Source Type: research
Antioxidative neuroprotective role of iron-gallic acid coordination nanoparticles and PET/MR usage in an ischemia stroke model
Conclusions: Fe-GA CPNs exhibit an impressive antioxidative neuroprotective role in ischemia stroke, which might have the potential to be translated into clinical applications for improved treatment of patients with stroke. PET/MRI is effective and accurate method for ischemic evaluation.
Source: Journal of Nuclear Medicine - May 20, 2019 Category: Nuclear Medicine Authors: KANG, L., Jiang, D., NI, D., Ehlerding, E., Wang, R., Cai, W. Tags: Basic Science I (Neurosciences) Source Type: research
Framework DNA nanocages alleviate ischemic stroke via intrathecal injection
Conclusions: Zr-89 and 800CW labeled DNA nanocage framework could be safely delivered to rat brains via intrathecal injection and imaged using PET imaging and fluorescence imaging. The delivered DNA nanocages may protected rats from ischemic stroke by neutralizing ROS. This DNA framework holds great promise for stroke prevention and potential clinical translation.
Source: Journal of Nuclear Medicine - May 20, 2019 Category: Nuclear Medicine Authors: Jiang, D., NI, D., Li, S., Ehlerding, E., Sun, T., Cao, T., Chen, W., Engle, J., Cai, W. Tags: Novel Multimodality and Nonradioactive Probes Source Type: research
Radionuclide Imaging in Ischemic Stroke
Ischemic stroke is caused by interruption or significant impairment of blood supply to the brain, which leads to a cascade of metabolic and molecular alterations resulting in functional disturbance and morphologic damage. The changes in regional cerebral blood flow and regional metabolism can be assessed by radionuclide imaging, especially SPECT and PET. SPECT and PET have broadened our understanding of flow and metabolic thresholds critical for maintenance of brain function and morphology: PET was essential in the transfer of the concept of the penumbra to clinical stroke and thereby had a great impact on developing treat...
Source: Journal of Nuclear Medicine - November 3, 2014 Category: Radiology Authors: Heiss, W.-D. Tags: Continuing Education Source Type: research
Microglial activation in recent ischemic stroke: comparison of two TSPO tracers
Conclusion: The apparent intensity of microglial activation in ischemic stroke is closely comparable between 18F-GE180 and 11C-(R)-PK11195 PET. Research Support: The study is funded by a grant from NIHR and supported by GEHC and INMIND (EC FP7).
Source: Journal of Nuclear Medicine - May 24, 2017 Category: Nuclear Medicine Authors: Herholz, K., Hinz, R., Visi, E., Trigg, W., McDonald, K., Punter, M., Majid, A., Gerhard, A. Tags: Neurology Posters Source Type: research
A study of the brain protective effects and mechanism of stroke rats with allopurinol by 18F- FMISO PET imaging
Conclusion (1) 18F-FMISO imaging can accurately show the cerebral ischemia penumbra . (2) Allopurinol can reduce the degree of hypoxia of ischemic brain tissue.(3) Allopurinol affects the 8F-FMISO uptake of brain tissues by the activity of xanthine oxidase.
Source: Journal of Nuclear Medicine - May 23, 2018 Category: Nuclear Medicine Authors: Li, Y., Li, A. Tags: Basic Science I Source Type: research
11C-DPA-713 Versus 18F-GE-180: A Preclinical Comparison of Translocator Protein 18 kDa PET Tracers to Visualize Acute and Chronic Neuroinflammation in a Mouse Model of Ischemic Stroke
Conclusion: 11C-DPA-713 and 18F-GE-180 PET enable detection of neuroinflammation at acute and chronic time points after cerebral ischemia in mice. 11C-DPA-713 PET reflects the extent of microglial activation in infarcted distal middle cerebral artery occlusion mouse brain tissue more accurately than 18F-GE-180 and appears to be slightly more sensitive. These results highlight the potential of 11C-DPA-713 for tracking microglial activation in vivo after stroke and warrant further investigation in both preclinical and clinical settings.
Source: Journal of Nuclear Medicine - January 2, 2019 Category: Nuclear Medicine Authors: Chaney, A., Cropper, H. C., Johnson, E. M., Lechtenberg, K. J., Peterson, T. C., Stevens, M. Y., Buckwalter, M. S., James, M. L. Tags: Basic Source Type: research
Validation of MRI Determination of the Penumbra by PET Measurements in Ischemic Stroke
The concept of the ischemic penumbra was formulated on the basis of animal experiments showing functional impairment and electrophysiologic disturbances with decreasing flow to the brain below defined values (the threshold for function) and irreversible tissue damage with blood supply further decreased (the threshold for infarction). The perfusion range between these thresholds was termed the "penumbra," and restitution of flow above the functional threshold was able to reverse the deficits without permanent damage. In further experiments, the dependency of the development of irreversible lesions on the interaction of the ...
Source: Journal of Nuclear Medicine - January 31, 2017 Category: Nuclear Medicine Authors: Heiss, W.-D., Zaro Weber, O. Tags: The State of the Art Source Type: research
Polyoxometalate nanoclusters act as broad-spectrum antioxidants to alleviate ischemic stroke by intrathecal injection
Conclusion: Intrathecal injection significantly improved the delivery and efficacy of POM nanoclusters to the brain, resulting in the rapid accumulation of POM nanoclusters in the ischemic penumbra. Due to this, we confirmed that the POM nanoclusters could be used as nano-antioxidants to inhibit oxidative stress as well as inflammatory damage effectively.
Source: Journal of Nuclear Medicine - May 14, 2020 Category: Nuclear Medicine Authors: Rosenkrans, Z., Li, S., Jiang, D., NI, D., Engle, J., Cai, W. Tags: Center for Molecular Imaging Innovation & amp; Translation (CMIIT) YIA Symposium Source Type: research
Improving Cerebral Blood Flow Through Liposomal Delivery of Angiogenic Peptides: Potential of 18F-FDG PET Imaging in Ischemic Stroke Treatment
Conclusion: Liposomal delivery of angiogenic peptides benefits cerebral ischemia. 18F-FDG PET imaging holds promise as an indicator of the effectiveness of angiogenic therapy in cerebral ischemia.
Source: Journal of Nuclear Medicine - July 1, 2015 Category: Nuclear Medicine Authors: Hwang, H., Jeong, H.-S., Oh, P.-S., Na, K.-S., Kwon, J., Kim, J., Lim, S., Sohn, M.-H., Jeong, H.-J. Tags: Basic Science Investigations Source Type: research
