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Effects of liraglutide on hemodynamic parameters in patients with heart failure.
This study aimed to evaluate the effects of liraglutide on hemodynamic parameters in patients with heart failure. A total of 78 patients with heart failure were enrolled in this study between August 2014 and November 2015. Of these, 52 patients were randomized 1:1 to receive either liraglutide or placebo for 7 days. Hemodynamic measurements were made using transpulmonary thermodilution and arterial pulse contour analysis. At 7 days, the difference in change of the primary endpoint of cardiac output between the liraglutide group and control group was +1.1 1/min (95% CI +0.1 to +2.2; P < 0.001). Stroke volume was signific...
Source: Oncotarget - June 25, 2017 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Role of seizure in neonatal stroke.
Authors: Auvin S, Charriaut-Marlangue C PMID: 28562317 [PubMed - as supplied by publisher]
Source: Oncotarget - June 2, 2017 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Association between body mass index and presence of carotid plaque among low-income adults aged 45 years and older: a population-based cross-sectional study in rural China.
Authors: Lou Y, Li B, Su L, Mu Z, Sun M, Gu H, Ni J, Wu Y, Tu J, Wang J, Ning X Abstract Carotid plaque is a good surrogate endpoint for assessing arterial atherosclerosis, and atherosclerosis is a reliable predictor of cardiovascular diseases. However, the effect of body mass index on carotid plaque is unknown. Therefore, we aimed to explore the association between body mass index and carotid plaque in a low-income Chinese population. Residents aged ≥45 years and free of stroke and cardiovascular diseases were enrolled and divided into four groups based on body mass index. B-mode ultrasonography was performed to...
Source: Oncotarget - May 20, 2017 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

A risk prediction model for post-stroke depression in Chinese stroke survivors based on clinical and socio-psychological features.
CONCLUSION: This study provided an effective risk model for PSD and indicated that the socio-psychological factors were important risk factors of PSD. PMID: 28446713 [PubMed - as supplied by publisher]
Source: Oncotarget - April 29, 2017 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

PKC and CaMK-II inhibitions coordinately rescue ischemia-induced GABAergic neuron dysfunction.
Authors: Huang L, Wang C, Zhao S, Ge R, Guan S, Wang JH Abstract Cerebral ischemia leads to neuronal death for stroke, in which the imbalance between glutamatergic neurons and GABAergic neurons toward neural excitotoxicity is presumably involved. GABAergic neurons are vulnerable to pathological factors and impaired in an early stage of ischemia. The rescue of GABAergic neurons is expected to be the strategy to reserve ischemic neuronal impairment. As protein kinase C (PKC) and calmodulin-dependent protein kinase II (CaMK-II) are activated during ischemia, we have investigated whether the inhibitions of these kinase...
Source: Oncotarget - April 27, 2017 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Pannexin1 knockout and blockade reduces ischemic stroke injury in female, but not in male mice.
Authors: Freitas-Andrade M, Bechberger JF, MacVicar BA, Viau V, Naus CC Abstract The membrane channel Pannexin 1 (Panx1) mediates apoptotic and inflammatory signaling cascades in injured neurons, responses previously shown to be sexually dimorphic under ischemic conditions. We tested the hypothesis that Panx1 plays an underlying role in mediating sex differences in stroke outcome responses. Middle-aged, 8-9 month old male and female wild type and Panx1 KO mice were subjected to permanent middle cerebral artery (MCA) occlusion, and infarct size and astrocyte and microglia activation were assessed 4 days later. The s...
Source: Oncotarget - April 27, 2017 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Heat stress induces intestinal injury through lysosome- and mitochondria-dependent pathway in vivo and in vitro.
Authors: Yi G, Li L, Luo M, He X, Zou Z, Gu Z, Su L Abstract Damage to the small intestine secondary to heat stroke is a major factor in heat stroke-related morbidity and mortality. However, the underlying mechanisms by which heat stroke causes small intestinal lesions and dysfunction remain unclear. To explore the pathogenesis of small intestinal tissue and epithelial cell injury, the SW480 cell heat stress model and the mice heat stroke model were established to mimic heat stroke. Morphologic changes in intestinal tissue and increased TUNEL-positive index were induced by heat stress in vivo. Heat stress activated...
Source: Oncotarget - April 6, 2017 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Dimethyl fumarate for ischemic stroke.
Authors: Kunze R PMID: 28209921 [PubMed - as supplied by publisher]
Source: Oncotarget - February 18, 2017 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Relationship of thyroid function with intracranial arterial stenosis and carotid atheromatous plaques in ischemic stroke patients with euthyroidism.
In conclusion, low free thyroxine levels were independently associated with carotid atheromatous plaques in ischemic stroke patients with euthyroidism, but thyroid function indicators were not associated with intracranial artery stenosis. PMID: 28147329 [PubMed - as supplied by publisher]
Source: Oncotarget - February 3, 2017 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Relation between baseline plaque features and subsequent coronary artery remodeling determined by optical coherence tomography and intravascular ultrasound.
We examined the influence of baseline plaque characteristics on subsequent vascular remodeling in response to changes in plaque size. Using optical coherence tomography (OCT) and intravascular ultrasound (IVUS), we examined 213 plaques from 138 patients with acute coronary syndrome at baseline and repeated IVUS at the 12-month follow-up. The change in external elastic membrane (EEM) area for each 1 mm2 change in plaque area (i.e., the slope of the regression line) was calculated as a measure of vascular remodeling capacity. In plaques with static positive remodeling, the slope was smaller than in plaques without static pos...
Source: Oncotarget - December 20, 2016 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Multi-delay ASL can identify leptomeningeal collateral perfusion in endovascular therapy of ischemic stroke.
CONCLUSIONS: Higher leptomeningeal collateral perfusion scores on CBV images by ASL may be a specific marker of clinical outcome after endovascular treatment in patients with acute MCA ischemic stroke. Further study with larger sample size is warranted. PMID: 27974692 [PubMed - as supplied by publisher]
Source: Oncotarget - December 16, 2016 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Distance to Thrombus in acute middle cerebral artery stroke predicts basal ganglia infarction after mechanical thrombectomy.
CONCLUSION: In MCA stroke, the exact site of the occlusion as measured by DT independently predicts the involvement of LSAs and subsequent striatocapsular infarction with high sensitivity and specificity. PMID: 27845905 [PubMed - as supplied by publisher]
Source: Oncotarget - November 16, 2016 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Therapeutic effects of umbilical cord blood plasma in a rat model of acute ischemic stroke.
This study provides valuable insights into the development of a safe, effective, and cell-free strategy for the treatment of ischemic brain damage and a much-needed alternative for patients who are ineligible for thrombolytic therapy. PMID: 27816964 [PubMed - as supplied by publisher]
Source: Oncotarget - November 8, 2016 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Intravenous administration of xenogenic adipose-derived mesenchymal stem cells (ADMSC) and ADMSC-derived exosomes markedly reduced brain infarct volume and preserved neurological function in rat after acute ischemic stroke.
In conclusion, xenogenic ADMSC/ADMSC-derived exosome therapy was safe and offered the additional benefit of reducing BIZ and improving neurological function in rat AIS. PMID: 27793019 [PubMed - as supplied by publisher]
Source: Oncotarget - October 31, 2016 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

The components of Huang-Lian-Jie-Du-Decoction act synergistically to exert protective effects in a rat ischemic stroke model.
This study investigated the efficacy of various combinations of the major components of HLJDD, berberine (A), baicalin (B), and jasminoidin (C), on the treatment of ischemic stroke modeled by middle cerebral artery occlusion (MCAO) in rats. The effects of A, B and C individually and their combinations were investigated using proton nuclear magnetic resonance (1H NMR)-based metabolomics complemented with neurologic deficit scoring, infarct volume measurement, biochemistry, histopathology and immunohistochemistry, as well as quantitative real-time polymerase chain reaction (qRT-PCR) and western blotting. Ischemic stroke prod...
Source: Oncotarget - October 27, 2016 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

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