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Positive impact of pre-stroke surgery on survival following transient focal ischemia in hypertensive rats
We describe a positive influence of pre-stroke surgery on recovery and survival in a commonly used experimental stroke model. Two groups of male, stroke-prone spontaneously hypertensive rats (SHRSPs) underwent transient middle cerebral artery occlusion (tMCAO). Group 1 underwent the procedure without any prior intervention whilst group 2 had an additional general anaesthetic 6 days prior to tMCAO for a cranial burrhole and durotomy. Post-stroke recovery was assessed using a 32 point neurological deficit score and tapered beam walk and infarct volume determined from haematoxylin–eosin stained sections. In group 2 survival...
Source: Journal of Neuroscience Methods - November 8, 2014 Category: Neuroscience Source Type: research

Model of minor stroke with mild peri-infarct ischemic injury
Conclusions The modified photothrombotic procedure will produce a minor stroke consisting of a small infarct in a region with marked diffusion and T2 hyperintensities and a peri-infarct region of selective necrosis with modest T2 changes. Minor recurrent stroke is readily produced but imaging is key for assessing size and location of each insult.
Source: Journal of Neuroscience Methods - May 10, 2016 Category: Neuroscience Source Type: research

Extraction of corticospinal tract microstructural properties in chronic stroke
Conclusion Differences in this data set highlight the need to establish a common methodology for CST reconstruction and analysis which may eliminate discrepancies in interpreting DWI and enhance biomarker use post-stroke for motor function.
Source: Journal of Neuroscience Methods - March 8, 2018 Category: Neuroscience Source Type: research

Critical differences between two classical surgical approaches for middle cerebral artery occlusion-induced stroke in mice
Conclusions In conclusion, we suggest that the Longa method is superior for the study of both short and long-term outcomes of ischemic stroke. These results have considerable implications on stroke model selection for researchers.
Source: Journal of Neuroscience Methods - May 16, 2015 Category: Neuroscience Source Type: research

Refining Forelimb Asymmetry Analysis: Correlation with Montoya Staircase Contralateral Function Post-Stroke
Conclusions This refinement of the Forelimb Asymmetry analysis improves correlation with Montoya Staircase contralateral function after stroke.
Source: Journal of Neuroscience Methods - July 22, 2017 Category: Neuroscience Source Type: research

A comparison of seven different dti-derived estimates of corticospinal tract structural characteristics in chronic stroke survivors
Conclusion We recommend this method for future research seeking to understand brain-behavior mechanisms of motor recovery in chronic stroke survivors.
Source: Journal of Neuroscience Methods - April 22, 2018 Category: Neuroscience Source Type: research

Sleep as a model to understand neuroplasticity and recovery after stroke: observational, perturbational and interventional approaches
Publication date: Available online 17 December 2018Source: Journal of Neuroscience MethodsAuthor(s): Armand Mensen, Andrea Pigorini, Laura Facchin, Cornelia Schöne, Sasha D'Ambrosio, Jasmine Jendoubi, Valeria Jaramillo, Kathrin Studer, Aleksandra Eberhard-Moscicka, Simone Sarasso, Antoine Adamantidis, René Müri, Reto Huber, Marcello Massimini, Claudio BassettiAbstractOur own experiences with disturbances to sleep demonstrate its crucial role in the recovery of cognitive functions. This importance is likely enhanced in the recovery from stroke; both in terms of its physiology and cognitive abilities. Decades of experimen...
Source: Journal of Neuroscience Methods - December 18, 2018 Category: Neuroscience Source Type: research

A reliability assessment of constrained spherical deconvolution-based diffusion-weighted magnetic resonance imaging in individuals with chronic stroke
Conclusion Future work should address the reproducibility and utility of CSD-based metrics of tract number and tract volume.
Source: Journal of Neuroscience Methods - October 24, 2015 Category: Neuroscience Source Type: research

Systematic review of survival time in experimental mouse stroke with impact on reliability of infarct estimation
Conclusion Our study shows that infarct size estimations are often performed around the peak time of edema, with a median of 24h. Most studies do consider edema formation, however, there is no consensus on what method to use to correct for edema. Furthermore, investigations into neuroprotective drugs should use longer survival times to ensure completion of the investigated process. Our findings indicate a need for more research in this area, and establishment of common correction methodology.
Source: Journal of Neuroscience Methods - January 12, 2016 Category: Neuroscience Source Type: research

An RFID-based activity tracking system to monitor individual rodent behavior in environmental enrichment: Implications for post-stroke cognitive recovery
ConclusionThis study represents an attempt to better align preclinical and clinical implementations of EE and facilitate the uptake of this intervention in the clinical setting.
Source: Journal of Neuroscience Methods - May 30, 2019 Category: Neuroscience Source Type: research

Function Based Brain Modeling and Simulation of an Ischemic Region in Post-Stroke Patients using the Bidomain
Conclusions. These results hold promise in improving the understanding of brain deterioration in stroke patients and the re-arrangement of brain networks. Furthermore, shows the use of functionality based brain modeling.
Source: Journal of Neuroscience Methods - November 15, 2019 Category: Neuroscience Source Type: research

Refinement of embolic stroke model in rats: effect of post-embolization anesthesia duration on arterial blood pressure, cerebral edema and mortality
Conclusions These data indicate that early discontinuation of isoflurane anesthesia after clot embolization permits an earlier hypertensive response that limits edema formation and mortality without significantly affecting infarct volume in survivors, thereby decreasing the required number of animals.
Source: Journal of Neuroscience Methods - June 20, 2018 Category: Neuroscience Source Type: research

Refinement of embolic stroke model in rats: Effect of post-embolization anesthesia duration on arterial blood pressure, cerebral edema and mortality
ConclusionsThese data indicate that early discontinuation of isoflurane anesthesia after clot embolization permits an earlier hypertensive response that limits edema formation and mortality without significantly affecting infarct volume in survivors, thereby decreasing the required number of animals.
Source: Journal of Neuroscience Methods - July 5, 2018 Category: Neuroscience Source Type: research

A systematic review investigating the relationship of electroencephalography and magnetoencephalography measurements with sensorimotor upper limb impairments after stroke
ConclusionsAlterations in neural activity by means of EEG and MEG are demonstrated from the early post-stroke stage onwards, and related to sensorimotor upper limb impairment.Future work exploring cortical oscillatory signals in the acute stage could provide further insight about prediction of upper limb recovery.
Source: Journal of Neuroscience Methods - August 14, 2018 Category: Neuroscience Source Type: research

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