Sleep as a model to understand neuroplasticity and recovery after stroke: observational, perturbational and interventional approaches

Publication date: Available online 17 December 2018Source: Journal of Neuroscience MethodsAuthor(s): Armand Mensen, Andrea Pigorini, Laura Facchin, Cornelia Schöne, Sasha D'Ambrosio, Jasmine Jendoubi, Valeria Jaramillo, Kathrin Studer, Aleksandra Eberhard-Moscicka, Simone Sarasso, Antoine Adamantidis, René Müri, Reto Huber, Marcello Massimini, Claudio BassettiAbstractOur own experiences with disturbances to sleep demonstrate its crucial role in the recovery of cognitive functions. This importance is likely enhanced in the recovery from stroke; both in terms of its physiology and cognitive abilities. Decades of experimental research have highlighted which aspects and mechanisms of sleep are likely to underlie these forms of recovery. Conversely, damage to certain areas of the brain, as well as the indirect effects of stroke, may disrupt sleep. However, only limited research has been conducted which seeks to directly explore this bidirectional link between both the macro and micro-architecture of sleep and stroke. Here we describe a series of semi-independent approaches that aim to establish this link through observational, perturbational, and interventional experiments. Our primary aim is to describe the methodology for future clinical and translational research needed to delineate competing accounts of the current data. At the observational level we suggest the use of high-density EEG recording, combined analysis of macro and micro-architecture of sleep, detailed analysis ...
Source: Journal of Neuroscience Methods - Category: Neuroscience Source Type: research