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Specialty: Biology
Source: Life Sciences
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Total 65 results found since Jan 2013.
Role of fractalkine/CX3CR1 signaling pathway in the recovery of neurological function after early ischemic stroke in a rat model
This study aims to explore the role of fractalkine/CX3C chemokine receptor 1 (CX3CR1) signaling pathway in the recovery of neurological functioning after an early ischemic stroke in rats. After establishment of permanent middle cerebral artery occlusion (pMCAO) models, 50 rats were divided into blank, sham, model, positive control and CX3CR1 inhibitor groups. Neurological impairment, walking and grip abilities, and cortical and hippocampal infarctions were evaluated by Zea Longa scoring criterion, beam-walking assay and grip strength test, and diffusion-weighted magnetic resonance imaging. qRT-PCR and Western blotting were...
Source: Life Sciences - July 19, 2017 Category: Biology Source Type: research
A selective cannabinoid CB2 agonist attenuates damage and improves memory retention following stroke in mice
Publication date: Available online 30 May 2015 Source:Life Sciences Author(s): Richard D. Ronca , Alyssa M. Myers , Doina Ganea , Ronald F. Tuma , Ellen A. Walker , Sara Jane Ward Aims We have recently demonstrated that treatment with a cannabinoid CB2 agonist was protective in a mouse middle cerebral artery occlusion model of cerebral ischemia/reperfusion injury. The present study aimed to determine whether these protective effects of CB2 agonism would extend to a mouse photoinjury model of permanent ischemia and determine associated alterations in cognition and infarct size. Main Methods Mice received three injections...
Source: Life Sciences - May 31, 2015 Category: Biology Source Type: research
Nerve growth factor-carbon nanotube complex exerts prolonged protective effects in an in vitro model of ischemic stroke
Publication date: Available online 2 December 2016 Source:Life Sciences Author(s): Parichehr Hassanzadeh, Elham Arbabi, Fatemeh Atyabi, Rassoul Dinarvand Aims The therapeutic potential of nerve growth factor (NGF) against the neurological disorders may be negatively affected by its short half-life. Based on the superior properties of carbon nanotubes (CNTs) for controlled drug delivery, we aimed to prepare CNT-NGF complex and evaluate its effect in an in vitro model of ischemic stroke. Materials and methods Multi-walled CNTs (MWCNTs)-NGF complex was prepared using amino-functionalized COOH-MWCNTs and characterized by Four...
Source: Life Sciences - December 2, 2016 Category: Biology Source Type: research
Proteomic analyses identify a potential mechanism by which extracellular vesicles aggravate ischemic stroke
Publication date: Available online 7 June 2019Source: Life SciencesAuthor(s): Xintong Wang, Jiaoqi Wang, Xiaohua Shi, Chengliang Pan, Hongyu Liu, Yue Dong, Rui Dong, Jing Mang, Zhongxin XuAbstractAimsExtracellular vesicles (EVs) are vital for information exchange between donor and recipient cells. When cells are stressed (e.g., by oxygen glucose deprivation, OGD), the complex information carried by the EVs is altered by the donor cells. Here, we aimed to analyze the proteomic differences between EVs derived from OGD-damaged cells and EVs derived from undamaged cells to explore the potential mechanisms by which EVs aggravat...
Source: Life Sciences - June 7, 2019 Category: Biology Source Type: research
Surprising outcomes in cannabinoid CB1/CB2 receptor double knockout mice in two models of ischemia
Publication date: 15 February 2018 Source:Life Sciences, Volume 195 Author(s): Sara Jane Ward, Francesca Castelli, Zachary W. Reichenbach, Ronald F. Tuma Aims We tested the hypothesis that CB1/CB2 receptor double knockout would produce significant increases in infarct size and volume and significant worsening in clinical score, using two mouse models, one of permanent ischemia and one of ischemia/reperfusion. Main methods Focal cerebral infarcts were created using either photo induced permanent injury or transient middle cerebral artery occlusion. Infarct volume and motor function were evaluated in cannabinoid receptor 1/...
Source: Life Sciences - January 5, 2018 Category: Biology Source Type: research
MiR-145 protected the cell viability of human cerebral cortical neurons after oxygen-glucose deprivation by downregulating EPHA4
In this study, we aimed to further explore their function in a model of oxygen-glucose deprivation (OGD). The expression of miR-145 in the blood of 44 patients with ischemic stroke and 37 normal controls was detected by qRT-PCR. After transfection with either the wild- or mutant-type pGL3-promoter EPHA4 3′UTR into the miR-145 mimic and miR-145 inhibitor, a dual-luciferase reporter assay was performed to explore the interaction between miR-145 and EPHA4. qRT-PCR and Western blot were performed to further explore the effects of miR-145 on EPHA4 expression after an miR-145 mimic, an miR-145 inhibitor or LV-sh-EPHA4 was tran...
Source: Life Sciences - May 29, 2019 Category: Biology Source Type: research
Ferulic acid-loaded nanostructured lipid carriers: A promising nanoformulation against the ischemic neural injuries
Publication date: 15 January 2018 Source:Life Sciences, Volume 193 Author(s): Parichehr Hassanzadeh, Elham Arbabi, Fatemeh Atyabi, Rassoul Dinarvand Aims Treatment of the ischemic stroke has remained a major healthcare challenge. The phenolic compound, ferulic acid (FA), has shown promising antioxidant and neuroprotective effects, however, low bioavailability may negatively affect its efficiency. This, prompted us to incorporate FA into the nanostructured lipid carriers (FA-NLCs) and evaluate its therapeutic potential in in vitro and in vivo models of ischemic stroke. Main methods FA-NLCs were prepared by high-pressure ho...
Source: Life Sciences - December 22, 2017 Category: Biology Source Type: research
4-((5-(Tert-butyl)-3-chloro-2-hydroxybenzyl) amino)-2-hydroxybenzoic acid protects against oxygen-glucose deprivation/reperfusion injury
Publication date: 1 July 2018 Source:Life Sciences, Volume 204 Author(s): Yuexinzi Jin, Xuelian Tang, Xiang Cao, Linjie Yu, Jian Chen, Haoran Zhao, Yan Chen, Lijuan Han, Xinyu Bao, Fei Li, Yun Xu Aims Oxidative stress is one of the most important pathological mechanisms which could aggravate ischemic stroke injury. In order to seek for better treatment therapies to alleviate stroke injury, novel chemicals have been synthetized. In the present study, a new compound 4-((5-(tert-butyl)-3-chloro-2-hydroxybenzyl) amino)-2- hydroxybenzoic acid, named LX009, was used to determine whether it could reduce the oxidative stress caus...
Source: Life Sciences - May 18, 2018 Category: Biology Source Type: research
Sitagliptin attenuates transient cerebral ischemia/reperfusion injury in diabetic rats: Implication of the oxidative–inflammatory–apoptotic pathway
Publication date: 1 April 2015 Source:Life Sciences, Volume 126 Author(s): Ayman E. El-Sahar , Marwa M. Safar , Hala F. Zaki , Amina S. Attia , Afaf A. Ain-Shoka Aims Ischemic stroke is a major macrovascular complication of diabetes mellitus. Sitagliptin, a dipeptidyl peptidase-IV inhibitor, was recently shown to improve cognitive functions in diabetic rats; hence the present study was conducted to evaluate its protective effect against transient ischemia–reperfusion (I/R) in diabetic animals. Main methods Diabetes was induced by streptozotocin (40mg/kg). Six weeks later, cerebral I/R was induced by bicommon carotid o...
Source: Life Sciences - March 11, 2015 Category: Biology Source Type: research
Adjuvant-induced mono-arthritis potentiates cerebral hemorrhage in the spontaneously hypertensive rats
Publication date: Available online 21 February 2016 Source:Life Sciences Author(s): Amy Randell, Noriko Daneshtalab Aims Patients with rheumatoid arthritis (RA), have a higher incidence of hypertension and stroke than the normal population. Currently there exists no animal model to study the pathogenic interactions of hemorrhagic stroke (HS) subsequent to chronic inflammation and hypertension. We have created and defined a hypertensive-mono-arthritic animal model who demonstrate gross signs of cerebral hemorrhage in presence of mono-arthritis. Main methods Spontaneously hypertensive rats (SHR) were fed either a high s...
Source: Life Sciences - February 21, 2016 Category: Biology Source Type: research
Memantine mediates neuroprotection via regulating neurovascular unit in a mouse model of focal cerebral ischemia
Publication date: 1 April 2016 Source:Life Sciences, Volume 150 Author(s): Zheng-Zhen Chen, Dan-Dan Yang, Zhan Zhao, Hui Yan, Juan Ji, Xiu-Lan Sun Aims Memantine is a low-moderate affinity and uncompetitive N-methyl-d-aspartate receptor (NMDAR) antagonist, which is also a potential neuroprotectant in acute ischemic stroke for its particular action profiles. The present study was to reveal the mechanisms involved in the neuroprotection of memantine. Main methods We used a mouse model of permanent focal cerebral ischemia via middle cerebral artery occlusion to verify our hypothesis. 2,3,5-Triphenyltetrazolium chlori...
Source: Life Sciences - March 3, 2016 Category: Biology Source Type: research
NLRP3 inflammasome activates interleukin-23/interleukin-17 axis during ischaemia-reperfusion injury in cerebral ischaemia in mice
Publication date: Available online 16 April 2019Source: Life SciencesAuthor(s): Haining Wang, Di Zhong, Hongping Chen, Jing Jin, Qingqing Liu, Guozhong LiAbstractAimsNLRP3 inflammasome has been reported associated with some inflammatory and autoimmune diseases. We previously researches showed that interleukin-23 (IL-23) and interleukin-17 (IL-17) aggravates the ischaemic injury of the brain tissue. However, it is poorly understood whether the NLPR3 inflammasome was involved in regulating and activating the IL-23/IL-17 axis in ischaemic stroke. We aimed to delineate whether the NLRP3 inflammasome signalling provokes the IL-...
Source: Life Sciences - April 17, 2019 Category: Biology Source Type: research
XQ-1H alleviates cerebral ischemia in mice through inhibition of apoptosis and promotion of neurogenesis in a Wnt/β-catenin signaling dependent way
Publication date: Available online 6 September 2019Source: Life SciencesAuthor(s): Dan Xu, Kai Hou, Fengyang Li, Shijie Chen, Weirong Fang, Yunman LiAbstractAims10-O-(N,N-dimethylaminoethyl)-ginkgolide B methanesulfonate (XQ-1H), a new derivative of ginkgolide B, has drawn great attention for its potent bioactivities against ischemia-induced injury. The purpose of this study was to further investigate the effect of XQ-1H against acute ischemic stroke by inducing middle cerebral artery occlusion/reperfusion (MCAO/R) injuries in mice.Main methodsTreatment of XQ-1H (78 or 39 mg/kg, i.g., bid) 2 h after MCAO improved motor...
Source: Life Sciences - September 7, 2019 Category: Biology Source Type: research
Treadmill exercise improves neurological function by inhibiting autophagy and the binding of HMGB1 to Beclin1 in MCAO juvenile rats
Publication date: Available online 8 January 2020Source: Life SciencesAuthor(s): Guoyuan Pan, Lingqin Jin, Weimin Shen, Jieqiong Zhang, Juanjuan Pan, Jingyan Cheng, Qingfeng Xie, Quan Hu, Shamin Wu, Hongmei Zhang, Xiang ChenAbstractAimsTreadmill exercise is a beneficial treatment following childhood stroke. Thus, studies focusing on the neuroprotective mechanism of exercise training during postischemic treatment in children with ischemic stroke are urgently needed. We evaluated the effects of treadmill exercise on autophagy after cerebral ischemia in young rats.Main methodsRats (23–25 days old) underwent cerebral ische...
Source: Life Sciences - January 9, 2020 Category: Biology Source Type: research
Postconditioning with a CpG containing Oligodeoxynucleotide ameliorates myocardial infarction in a murine closed-chest model
Publication date: Available online 29 October 2014 Source:Life Sciences Author(s): Se-Chan Kim , Shuijing Wu , Xiangming Fang , Jens Neumann , Lars Eichhorn , Grigorij Schleifer , Olaf Boehm , Rainer Meyer , Stilla Frede , Andreas Hoeft , Georg Baumgarten , Pascal Knuefermann Aims Toll-like receptor (TLR)9 ligand CpG-oligodeoxynucleotide (CpG-ODN) exerts preconditioning in myocardial ischemia/reperfusion. We hypothesized a postconditioning effect of CpG-ODN in a murine closed-chest model of myocardial infarction. Materials and Methods C57BL/6 (12weeks, male, WT) mice were instrumented at the left anterior descending art...
Source: Life Sciences - November 4, 2014 Category: Biology Source Type: research
