Filtered By:
Source: Journal of Neurochemistry
This page shows you your search results in order of relevance.
Order by Relevance | Date
Total 123 results found since Jan 2013.
Plasmatic retinol‐binding protein 4 and glial fibrillary acidic protein as biomarkers to differentiate ischemic stroke and intracerebral hemorrhage
We describe the discovery and subsequent replications of RBP4 and its combination with circulating GFAP as plasmatic biomarkers for hyperacute stroke subtype differentiation. The combination of these biomarkers and others might aid to speed up the discrimination of both stroke subtypes improving the outcome of patients.
A rapid differentiation of ischemic stroke from intracerebral hemorrhage is essential to provide the appropriate treatment. We describe the discovery and subsequent replications of RBP4 and its combination with circulating GFAP as plasmatic biomarkers for hyperacute stroke subtype differentiation. The comb...
Source: Journal of Neurochemistry - December 17, 2015 Category: Neuroscience Authors: Víctor Llombart, Teresa García‐Berrocoso, Alejandro Bustamante, Dolors Giralt, David Rodriguez‐Luna, Marian Muchada, Anna Penalba, Cristina Boada, Mar Hernández‐Guillamon, Joan Montaner Tags: Original Article Source Type: research
Gene expression profiling in whole blood stimulated ex vivo with lipopolysaccharide as a tool to predict post ‐stroke depressive symptoms: Proof‐of‐concept study
We studied if blood gene expression could facilitate identification of persons who will develop depression 3 months after ischemic stroke. Venous blood samples were collected on day 3 after stroke. Obtained blood was stimulated in vitro with lipopolysaccharide, a powerful inducer of gene expression. After stimulation, RNA was isolated and sequenced. Expression of 510 genes differed between patients who developed depression and those who had not depression after stroke. Bioinformatic analysis revealed that expression of 6 genes (PKM, PRRC2C, NUP188, CHMP3, H2AC8, NOP10) accurately predicted a risk of depression. Our finding...
Source: Journal of Neurochemistry - June 27, 2023 Category: Neuroscience Authors: Marcin Piechota,
Dzesika Hoinkis,
Michal Korostynski,
Slawomir Golda,
Joanna Pera,
Tomasz Dziedzic Tags: ORIGINAL ARTICLE Source Type: research
Activation of neuronal Ras ‐related C3 botulinum toxin substrate 1 (Rac1) improves post‐stroke recovery and axonal plasticity in mice
We propose that activation of neuronal Rac1 mediates the release of BDNF via PAK1 signaling, which further promotes axonal plasticity and alleviates astrogliosis, and eventually contributes to functional recovery after brain ischemia. Targeting neuronal Rac1 may offer a potential therapeutic target for promoting brain remapping and functional recovery after stroke. AbstractLong-term disability after stroke is common but the mechanisms of post-stroke recovery remain unclear. Cerebral Ras-related C3 botulinum toxin substrate (Rac) 1 contributes to functional recovery after ischemic stroke in mice. As Rac1 plays divergent rol...
Source: Journal of Neurochemistry - May 22, 2021 Category: Neuroscience Authors: Fan Bu,
Yashasvee Munshi,
J Weldon Furr,
Jia ‐wei Min,
Li Qi,
Anthony Patrizz,
Zachary R. Spahr,
Akihiko Urayama,
Julia K. Kofler,
Louise D. McCullough,
Jun Li Tags: ORIGINAL ARTICLE Source Type: research
Activation of Neuronal Ras ‐Related C3 Botulinum Toxin Substrate 1 (Rac1) Improves Post‐Stroke Recovery and Axonal Plasticity in Mice
AbstractLong ‐term disability after stroke is common but the mechanisms of post‐stroke recovery is unclear. Cerebral Ras‐related C3 botulinum toxin substrate (Rac) 1 contributes to functional recovery after ischemic stroke in mice. As Rac1 plays divergent roles in individual cell types after central neural system injury, we herein examined the specific role of neuronal Rac1 in post‐stroke recovery and axonal regeneration. Young male mice were subjected to 60‐minutes middle cerebral artery occlusion (MCAO). Inducible deletion of neuronal Rac1 by daily intraperitoneal injection of tamoxifen (2 mg/4 0 g) into Thy1...
Source: Journal of Neurochemistry - September 21, 2020 Category: Neuroscience Authors: Fan Bu,
Yashasvee Munshi,
J Weldon Furr,
Jia ‐wei Min,
Li Qi,
Anthony Patrizz,
Zachary R. Spahr,
Akihiko Urayama,
Julia K. Kofler,
Louise D. McCullough,
Jun Li Tags: ORIGINAL ARTICLE Source Type: research
Hyaluronidase inhibition accelerates functional recovery from stroke in the mouse brain
Hyaluronic acid (HA) is the main component of the brain extracellular matrix (ECM). During stroke, a massive breakdown of HA occurs (including perineuronal net ‐associated HA), however, the mechanism of this phenomenon remains unclear. We hypothesized that stroke up‐regulates the expression of HA metabolism‐associated enzymes and increases HA synthesis/degradation. We observed increased expression of HA‐degrading hyaluronidases and hexosaminidases, as well as HA synthases. Immunofluorescence studies revealed predominating astrocytic origin of the enzymes. Moreover, we found that inhibiting hyaluronidases with Vcpal...
Source: Journal of Neurochemistry - January 5, 2021 Category: Neuroscience Authors: Anna Katarzyna Greda,
Dorota Nowicka Tags: ORIGINAL ARTICLE Source Type: research
Dense dopaminergic innervation of the peri ‐infarct cortex despite dopaminergic cell loss after a pure motor‐cortical stroke in rats
In this study, we assessed the reorganization of dopaminergic innervation of the PIC in a rat model of focal cortical stroke. Our data suggest a sprouting of dopaminergic fibers into the PIC and point to a role for dopaminergic signaling in reparative mechanisms post-stroke, potentially related to recovery. AbstractAfter ischemic stroke, the cortex directly adjacent to the ischemic core (i.e., the peri-infarct cortex, PIC) undergoes plastic changes that facilitate motor recovery. Dopaminergic signaling is thought to support this process. However, ischemic stroke also leads to the remote degeneration of dopaminergic midbrai...
Source: Journal of Neurochemistry - September 22, 2023 Category: Neuroscience Authors: Sibylle Frase,
Julius Steddin,
Enya Paschen,
Maximilian Lenz,
Pasquale Conforti,
Carola A. Haas,
Andreas Vlachos,
Christian Schachtrup,
Jonas A. Hosp Tags: ORIGINAL ARTICLE Source Type: research
Role of serum ‐ and glucocorticoid‐inducible kinases in stroke
Abstract
Increased expression of serum‐ and glucocorticoid‐inducible kinase 1 (SGK1) can be induced by stress and growth factors in mammals, and plays an important role in cancer, diabetes, and hypertension. A recent work suggested that SGK1 activity restores damage in a stroke model. To further investigate the role of SGKs in ischemic brain injury, we examined how SGK inhibitors influence stroke outcome in vivo and neurotoxicity in vitro. Infarct volumes were compared in adult mice with middle cerebral artery occlusion, followed by 24 h reperfusion, in the absence or presence of SGK inhibitors. Neurotoxicity assay,...
Source: Journal of Neurochemistry - May 24, 2016 Category: Neuroscience Authors: Koichi Inoue, Tiandong Leng, Tao Yang, Zhao Zeng, Takatoshi Ueki, Zhi ‐Gang Xiong Tags: Original Article Source Type: research
HDAC2 (Histone deacetylase 2): a critical factor in environmental enrichment ‐mediated stroke recovery
In this study, focal stroke was induced by photothrombosis in male mice exposing to EE or standard housing (SH) conditions. Recombinant virus vectors, including Ad‐HDAC2‐Flag, AAV‐CAG‐EGFP‐Cre, LV‐shHDAC2 or their controls were microinjected into the motor co rtex at 3 d before stroke. Grid‐walking and cylinder tasks were conducted to assess motor function. Western blot and immunostaining were used to uncover the mechanisms underlying EE‐mediated stroke recovery. We found that EE exposure reversed stroke‐induced HDAC2 upregulation, implicating HDAC 2 in EE‐mediated functional recovery. Importantly, EE...
Source: Journal of Neurochemistry - May 15, 2020 Category: Neuroscience Authors: Yu ‐Hui Lin,
Meng‐Cheng Yao,
Hai‐Yin Wu,
Jian Dong,
Huan‐Yu Ni,
Xiao‐Lin Kou,
Lei Chang,
Chun‐Xia Luo,
Dong‐Ya Zhu Tags: ORIGINAL ARTICLE Source Type: research
Neurosteroids: a novel promise for the treatment of stroke and post ‐stroke complications
AbstractStroke is the primary reason for death and disability worldwide, with few treatment strategies to date. Neurosteroids, which are natural molecules in the brain, have aroused great interest in the field of stroke. Neurosteroids are a kind of steroid that acts on the nervous system, and are synthesized in the mitochondria of neurons or glial cells using cholesterol or other steroidal precursors. Neurosteroids mainly include estrogen, progesterone (PROG), allopregnanolone, dehydroepiandrosterone (DHEA), and vitamin D (VD). Most of the preclinical studies have confirmed that neurosteroids can decrease the risk of strok...
Source: Journal of Neurochemistry - September 5, 2021 Category: Neuroscience Authors: Jiawei Xu,
Yunxiang Zhou,
Caochong Yan,
Xiaoyu Wang,
Jianyao Lou,
Yi Luo,
Shiqi Gao,
Junjie Wang,
Liang Wu,
Xiangfu Gao,
Anwen Shao Tags: REVIEW ARTICLE Source Type: research
Plasmatic RBP4 and GFAP as biomarkers to differentiate ischemic stroke and intracerebral hemorrhage
This article is protected by copyright. All rights reserved.
Source: Journal of Neurochemistry - November 3, 2015 Category: Neuroscience Authors: Víctor Llombart, Teresa García‐Berrocoso, Alejandro Bustamante, Dolors Giralt, David Rodriguez‐Luna, Marian Muchada, Anna Penalba, Cristina Boada, Mar Hernández‐Guillamon, Joan Montaner Tags: Original Article Source Type: research
Effects of ML351 and tissue plasminogen activator combination therapy in a rat model of focal embolic stroke
In conclusion, ML351 and tPA combination therapy is beneficial in ameliorating HT afte r ischemic stroke. This protective effect is probably because of 12/15‐LOX inhibition and suppression of JNK‐mediated microglia/macrophage activation.
Source: Journal of Neurochemistry - February 5, 2021 Category: Neuroscience Authors: Guangsen Cheng,
Wei Zhao,
Yongjie Xin,
Guomin Huang,
Yongkang Liu,
Zhongliang Li,
Meixiao Zhan,
Yong Li,
Ligong Lu,
Klaus Leyen,
Yu Liu Tags: ORIGINAL ARTICLE Source Type: research
Bioinformatics ‐based analysis of mechanistic differences in vascular endothelial injury ischemic stroke induced by atrial fibrillation and atherosclerosis
This study aimed to investigate the mechanistic differences in endothelial injury between atrial fibrillation (AF)- and AS-induced ischemic stroke. All target genes of AF, AS, and the vascular endothelial cell (VC) were obtained from the GeneCards database; the differential genes of AF and AS separately associated with the VC were established by a Venn diagram. A protein –protein interaction network was created, and Gene Ontology and Kyoto Encyclopedia of Genes and Genomes databases were used to perform genomic enrichment and functional enrichment analysis. Hub genes were selected by Maximal Clique Centrality algorithm r...
Source: Journal of Neurochemistry - June 2, 2023 Category: Neuroscience Authors: Jia Li,
Rui Yang,
Shenglin Wang,
Ziyi Shen,
Bowen Wu,
Yu Ren,
Sha Ke,
Guohui Jiang Tags: ORIGINAL ARTICLE Source Type: research
Antimicrobial Protein REG3A and Signaling Networks are Predictive of Stroke Outcomes
AbstractRegenerating Family Member 3 Alpha (REG3A) is a multifunctional protein with antimicrobial activity, and primarily secreted by the intestine and pancreas. Studies have shown an increased expression of REG3A in systemic inflammatory responses to acute injury and infection, but studies investigating REG3A during the pathogenesis of ischemic stroke are limited. The aims of this study were to examine the associations between arterial expression of REG3A and other arterial inflammatory proteins implicated in stroke pathogenesis, as well as associations between REG3A and markers of poor outcome for ischemic stroke. The U...
Source: Journal of Neurochemistry - September 24, 2021 Category: Neuroscience Authors: Madison Sands,
Jacqueline A. Frank,
Benton Maglinger,
Christopher J. McLouth,
Amanda L. Trout,
Jadwiga Turchan ‐Cholewo,
Ann M. Stowe,
Justin F. Fraser,
Keith R. Pennypacker Tags: ORIGINAL ARTICLE Source Type: research
Circulating metabolites associated with incident myocardial infarction and stroke: a prospective cohort study of 90,438 participants
AbstractThe relevance between circulating metabolites and vascular events remains controversial and comprehensive studies are lacking. We sought to investigate the prospective associations of plasma metabolomics with risks of incident stroke, ischemic stroke (IS), hemorrhagic stroke (HS) and myocardial infarction (MI). Within the UK Biobank cohort, 249 circulating metabolites were measured in 90,438 participants without baseline vascular diseases. Cox proportional hazards regressions were applied to estimate adjusted hazard ratios (HRs) for per 1 standard deviation increment in metabolites. The least absolute shrinkage and...
Source: Journal of Neurochemistry - June 28, 2022 Category: Neuroscience Authors: Yu Guo,
Shu ‐Fen Chen,
Ya‐Ru Zhang,
Hui‐Fu Wang,
Shu‐Yi Huang,
Shi‐Dong Chen,
Yue‐Ting Deng,
Bang‐Sheng Wu,
Kevin Kuo,
Rong‐Ze Wang,
Qiang Dong,
Jian‐Feng Feng,
Wei Cheng,
Jin‐Tai Yu Tags: ORIGINAL ARTICLE Source Type: research
Activation of σ1 and σ2 receptors by afobazole increases glial cell survival and prevents glial cell activation and nitrosative stress after ischemic stroke
This article is protected by copyright. All rights reserved.
Source: Journal of Neurochemistry - August 3, 2016 Category: Neuroscience Authors: C. Katnik, A. Garcia, A. A. Behensky, I.E. Yasny, A. M. Shuster, S. B. Seredenin, A. V. Petrov, J. Cuevas Tags: Original Article Source Type: research
