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Source: Hypertension
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Total 263 results found since Jan 2013.
Abstract P445: Sympathetic and Renal Mechanisms of Age-related Hypertension Session Title: Hypertension and Aging and Cerebrovascular Disease and Stroke
Hypothesis: Sympathoexcitation and sodium retention contribute to age-related hypertension (HTN).Methods: Three, 8, and 16 month old male SD rats underwent an IV volume expansion (VE; 5% BW) and MAP, HR, urine output and paraventricular nucleus (PVN) neuronal activation (c-Fos expression) were assessed. In separate groups of rats fed a 21 day normal (NS; 0.6% NaCl) or high salt (HS; 4% NaCl) diet, measures of 1) ex vivo afferent renal nerve (ARN) activity (norepinephrine (NE)-evoked substance P release) or 2) MAP, HR, NCC activity (ΔUNaV to IV HCTZ, 2mg/kg) and sympathetic tone (plasma and renal NE content, ΔMAP to IV he...
Source: Hypertension - September 14, 2017 Category: Cardiology Authors: Richard D Wainford, Alissa A Frame Tags: Poster Abstract Presentations Source Type: research
Abstract P446: Sestrin2 Suppresses Age-related Hypertrophy by Inhibiting mTORC1 Signaling Pathway Session Title: Hypertension and Aging and Cerebrovascular Disease and Stroke
Introduction: The mechanistic target of rapamycin complex 1 (mTORC1) plays a critical role in the regulation of cell growth and energy state. A novel stress-inducible protein, Sestrin2 was recognized as a sensor for mTORC1 pathway.Hypothesis: The cardiac mTORC1 activation modulated by Sestrin2 is impaired in aging that sensitizes heart to hypertrophy.Methods: C57BL/6J young WT (4-6 months) and aged WT mice (24-26 months), and young Sestrin2 knockout mice (4-6 months) were subjected to transverse aortic constriction (TAC) for pressure overload. The ex vivo working heart perfusion was used for measuring substrate metabolism....
Source: Hypertension - September 14, 2017 Category: Cardiology Authors: Nanhu Quan, Courtney Cates, Thomas Rousselle, Ji Li Tags: Poster Abstract Presentations Source Type: research
Abstract P447: Hesperidin, Ingredient of Citrus Fruits Juice, Attenuates Cognitive Impairment Induced by Ischemic Brain Damage Session Title: Hypertension and Aging and Cerebrovascular Disease and Stroke
Conclusion: Taken together, these results suggest that the intake of hesperidin in CI should prevent cognitive decline after brain ischemia at least in part due to reduction of oxidative stress and an increase in CBF.
Source: Hypertension - September 14, 2017 Category: Cardiology Authors: Moe Kawakami, Jun Iwanami, Kana Tsukuda, Akinori Higaki, Li-Juan Min, Masaki Mogi, Masatsugu Horiuchi Tags: Poster Abstract Presentations Source Type: research
Abstract P448: Interaction Between Ischemic Brain Inȷury and Amyloid-{beta} Deposition in Cognitive Decline; Possible Cognitive Protection by AT2Receptor Activation Session Title: Hypertension and Aging and Cerebrovascular Disease and Stroke
Conclusion: Ischemic brain injury could enhance Aβ-induced cognitive impairment with possible involvement of enhanced oxidative stress, neuron degeneration, and breakdown of RAGE-mediated Aβ clearance. AT2 receptor activation in VSMC could play inhibitory roles in the cognitive decline induced by ischemic brain damage and Aβ deposition.
Source: Hypertension - September 14, 2017 Category: Cardiology Authors: Li-Juan Min, Masaki Mogi, Kana Tsukuda, Hui-Yu Bai, Bao-Shuai Shan, Akinori Higaki, Jun Iwanami, Masatsugu Horiuchi Tags: Poster Abstract Presentations Source Type: research
Abstract P450: AT2 Receptor Stimulation Reduces Ischemic Brain Damage Through AT2 Receptor-interacting Protein Signal Session Title: Hypertension and Aging and Cerebrovascular Disease and Stroke
Conclusions: These results suggested that ATIP could enhance the cerebral protective effects of AT2 receptor stimulation at least in part due to the increase of CBF and MMS2 expression after ischemia.
Source: Hypertension - September 14, 2017 Category: Cardiology Authors: Jun Iwanami, Masaki Mogi, Xiao-Li Wang, Kana Tsukuda, Akinori Higaki, Masanori Kukida, Hirotomo Nakaoka, Toshifumi Yamauchi, Hui-Yu Bai, Bao-Shuai Shan, Li-Juan Min, Masatsugu Horiuchi Tags: Poster Abstract Presentations Source Type: research
Abstract P453: Hypertension Mortality Risk May be Fake News for Nonagenarians Session Title: Hypertension and Aging and Cerebrovascular Disease and Stroke
Background: Little is known regarding BP control and mortality risk in subjects greater than 90 years of age.Objective: This paper assesses the association between systolic blood pressure and mortality risk for nonagenarians.Methods: Data from the Veterans Administration Informatics and Computing Infrastructure were used to analyze the survival of 193,651 nonagenarians in 130 Veteran Administration medical centers. Following clinical guidelines, for each day, we selected the lowest Systolic reading of the day exceeding 90 mmHg and defined sustained pressure as the average of two consecutive readings at least one month apar...
Source: Hypertension - September 14, 2017 Category: Cardiology Authors: Raya E Kheirbek, Farrokh Alemi, Ross D Fletcher Tags: Poster Abstract Presentations Source Type: research
Abstract P465: Arterial Hypertension and Orthostatic Hypotension in Diabetic Patients Session Title: Obesity, Metabolic Syndrome, and Diabetes
Conclusion: Presence of orthostatic hypotension in diabetics is associated with higher prevalence of macrovascular and microvascular complications of diabetes mellitus and also with higher 10-year mortality.
Source: Hypertension - September 14, 2017 Category: Cardiology Authors: Ludovit Gaspar, Slavomira Filipova, Matej Bendzala, Iveta Gasparova Tags: Poster Abstract Presentations Source Type: research
Abstract P478: Barriers to Health Care Access and Hypertension Treatment Among Us Adults With Self-reported Hypertension Session Title: Antihypertensive Drugs and Pharmacology, Patient-Provider-Healthcare System Issues, and Pediatric and Adolescent Hypertension
Conclusion: Although antihypertensive medication use is common among those with hypertension, this study found lower levels of reported antihypertensive medication use among those with perceived barriers to health care access.
Source: Hypertension - September 14, 2017 Category: Cardiology Authors: Jing Fang, Guijing Wang, Carma Ayala, Sal Lucido, Fleetwood Loustatol Tags: Poster Abstract Presentations Source Type: research
Abstract P482: Different Hemodynamic Phenotypes Of Isolated Systolic Hypertension In Adolescents Session Title: Antihypertensive Drugs and Pharmacology, Patient-Provider-Healthcare System Issues, and Pediatric and Adolescent Hypertension
Objective: Isolated systolic hypertension (ISH) is a dominant form of primary hypertension (PH) in adolescents. Some of them present with normal central systolic blood pressure (cSBP), a phenomenon called spurious hypertension (sHT). The study was aimed to describe hemodynamics of PH in relation to cSBP, central pulse pressure (cPP) and target organ damage (TOD) in adolescents referred because of PH.Patients and Methods: In 267 children (59 girls; 14.9 ±2.6 years) referred with arterial hypertension, in whom secondary hypertension was excluded, 24 hour ABPM, left ventricular mass index (LVMi), carotid intima-media thickne...
Source: Hypertension - September 14, 2017 Category: Cardiology Authors: Lukasz Obrycki, Anna Niemirska, Jedrzej Sarnecki, Zbigniew Kulaga, Mieczyslaw Litwin Tags: Poster Abstract Presentations Source Type: research
Abstract P504: Resistin Mediates Sex-dependent Effects of Perivascular Adipose Tissue on Vascular Function in the SHRSP Session Title: Vascular
Conclusion: We identified a novel role for resistin in sex-dependent PVAT mediated vascular function in hypertension through a KATP channel mediated mechanism.
Source: Hypertension - September 14, 2017 Category: Cardiology Authors: Sarah McNeilly, Heather Y Small, Adam Sheikh, Sheon Mary, Karine Pinel, Christian Delles Tags: Poster Abstract Presentations Source Type: research
Endothelial Mineralocorticoid Receptor Mediates Parenchymal Arteriole and Posterior Cerebral Artery Remodeling During Angiotensin II-Induced HypertensionNovelty and Significance Brain
The brain is highly susceptible to injury caused by hypertension because the increased blood pressure causes artery remodeling that can limit cerebral perfusion. Mineralocorticoid receptor (MR) antagonism prevents hypertensive cerebral artery remodeling, but the vascular cell types involved have not been defined. In the periphery, the endothelial MR mediates hypertension-induced vascular injury, but cerebral and peripheral arteries are anatomically distinct; thus, these findings cannot be extrapolated to the brain. The parenchymal arterioles determine cerebrovascular resistance. Determining the effects of hypertension and ...
Source: Hypertension - November 8, 2017 Category: Cardiology Authors: Janice M. Diaz-Otero, Courtney Fisher, Kelsey Downs, M. Elizabeth Moss, Iris Z. Jaffe, William F. Jackson, Anne M. Dorrance Tags: Hypertension, Vascular Disease Original Articles Source Type: research
Aldosterone Target NGAL (Neutrophil Gelatinase-Associated Lipocalin) Is Involved in Cardiac Remodeling After Myocardial Infarction Through NF{kappa}B PathwayNovelty and Significance Heart
In conclusion, NGAL, a downstream MR activation target, is a key mediator of post-MI cardiac damage. NGAL may be a potential therapeutic target in cardiovascular pathological situations in which MR is involved.
Source: Hypertension - November 8, 2017 Category: Cardiology Authors: Ernesto Martinez–Martinez, Mathieu Buonafine, Ines Boukhalfa, Jaime Ibarrola, Amaya Fernandez–Celis, Peter Kolkhof, Patrick Rossignol, Nicolas Girerd, Paul Mulder, Natalia Lopez–Andres, Antoine Ouvrard–Pascaud, Frederic Jaisser Tags: Basic Science Research Original Articles Source Type: research
Uric Acid Is a Strong Risk Marker for Developing Hypertension From PrehypertensionNovelty and Significance Hyperuricemia and Prehypertension
Prehypertension frequently progresses to hypertension, a condition associated with high morbidity and mortality from cardiovascular diseases and stroke. However, the risk factors for developing hypertension from prehypertension remain poorly understood. We conducted a retrospective cohort study using the data from 3584 prehypertensive Japanese adults (52.1±11.0 years, 2081 men) found to be prehypertensive in 2004 and reexamined in 2009. We calculated the cumulative incidences of hypertension over 5 years, examined risk factors, and calculated odds ratios (ORs) for developing hypertension after adjustments for age, sex, bo...
Source: Hypertension - December 13, 2017 Category: Cardiology Authors: Masanari Kuwabara, Ichiro Hisatome, Koichiro Niwa, Shigeko Hara, Carlos A. Roncal-Jimenez, Petter Bjornstad, Takahiko Nakagawa, Ana Andres-Hernando, Yuka Sato, Thomas Jensen, Gabriela Garcia, Bernardo Rodriguez-Iturbe, Minoru Ohno, Miguel A. Lanaspa, Rich Tags: Cardiovascular Disease, Epidemiology, Risk Factors, High Blood Pressure, Hypertension Original Articles Source Type: research
Cerebrovascular Reactivity and Vascular Activation in Postmenopausal Women With Histories of PreeclampsiaNovelty and Significance Preeclampsia
This study examined an association between pregnancy history and CVR using a subgroup of 40 age- and parity-matched pairs of women having histories of preeclampsia (n=27) or normotensive pregnancy (n=29) and the association of activated blood elements with CVR. Middle cerebral artery velocity was measured by Doppler ultrasound before and during hypercapnia to assess CVR. Thirty-eight parameters of blood cellular elements, microvesicles, and cell–cell interactions measured in venous blood were assessed for association with CVR using principal component analysis. Middle cerebral artery velocity was lower in the preeclampsi...
Source: Hypertension - December 13, 2017 Category: Cardiology Authors: Jill N. Barnes, Ronee E. Harvey, Kathleen B. Miller, Muthuvel Jayachandran, Katherine R. Malterer, Brian D. Lahr, Kent R. Bailey, Michael J. Joyner, Virginia M. Miller Tags: Physiology, Preeclampsia, Cerebrovascular Disease/Stroke Original Articles Source Type: research
Day-by-Day Variability of Home Blood Pressure and Incident Cardiovascular Disease in Clinical PracticeNovelty and Significance Blood Pressure Variability
We assessed the relationship between day-by-day home blood pressure (BP) variability and incident cardiovascular disease (CVD) in clinical practice. J-HOP study (Japan Morning Surge-Home Blood Pressure) participants underwent home BP monitoring in the morning and evening for a 14-day period, and their BP levels and BP variability independent of the mean (VIM) were assessed. Incident CVD events included coronary heart disease and stroke. Cox models were fitted to assess the home BP variability–CVD risk association. Among 4231 participants (mean±SD age, 64.9±10.9 years; 53.3% women; 79.1% taking antihypertensive medicati...
Source: Hypertension - December 13, 2017 Category: Cardiology Authors: Satoshi Hoshide, Yuichiro Yano, Hiroyuki Mizuno, Hiroshi Kanegae, Kazuomi Kario Tags: Hypertension Original Articles Source Type: research
