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Specialty: Biomedical Science
Source: Aging
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Total 184 results found since Jan 2013.
Development and validation of a nomogram for predicting stroke risk in rheumatoid arthritis patients
In conclusion, the nomogram can be used for individualized preoperative prediction of stroke risk in RA patients.PMID:34081620 | DOI:10.18632/aging.203071
Source: Aging - June 3, 2021 Category: Biomedical Science Authors: Fangran Xin Lingyu Fu Bowen Yang Haina Liu Tingting Wei Cunlu Zou Bingqing Bai Source Type: research
Aging is associated with glial senescence in the brainstem - implications for age-related sympathetic overactivity
In conclusion, our study suggests that aging induces glial senescence in the brainstem which likely causes inflammation and SNS overactivity.PMID:34038388 | DOI:10.18632/aging.203111
Source: Aging - May 26, 2021 Category: Biomedical Science Authors: Priya Balasubramanian Lyndee Branen Mahesh Kumar Sivasubramanian Raisa Monteiro Madhan Subramanian Source Type: research
Identification of key pathways and genes in carotid atherosclerosis through bioinformatics analysis of RNA-seq data
This study aimed to explore the potential mechanism of CAS through RNA-seq data analysis. Carotid intima tissue samples from CAS patients and healthy subjects were subjected to RNA-seq analysis, which yielded, 1,427 differentially expressed genes (DEGs) related to CAS. Further, enrichment analysis (Gene Ontology, KEGG pathway, and MOCDE analysis) was performed on the DEGs. Hub genes identified via the protein-protein interaction network (PPI) were then analyzed using TRRUST, DisGeNET, PaGenBase, and CMAP databases. Results implicated inflammation and immunity in the pathogenesis of CAS. Also, lung disease was associated wi...
Source: Aging - May 11, 2021 Category: Biomedical Science Authors: Zhongchen Li Jiheng Hao Kun Chen Qunlong Jiang Peijian Wang Xiaohui Xing Jiyue Wang Yinjiang Zhang Yilei Xiao Liyong Zhang Source Type: research
Design and validation of a recognition instrument-the stroke aid for emergency scale-to predict large vessel occlusion stroke
CONCLUSIONS: The SAFE scale can accurately recognize LVOS at a rate comparable to those of other, similar scales.PMID:33902003 | DOI:10.18632/aging.202910
Source: Aging - April 26, 2021 Category: Biomedical Science Authors: Baorui Zhang Xiaochuan Huo Fei Yuan Guangrong Song Lang Liu Gaoting Ma Dapeng Mo Zhongxue Wu Zhongrong Miao Aihua Liu Source Type: research
MiR-27a-3p suppresses cerebral ischemia-reperfusion injury by targeting FOXO1
Aging (Albany NY). 2021 Apr 19;13. doi: 10.18632/aging.202866. Online ahead of print.ABSTRACTCerebral ischemia-reperfusion (CI/R) injury is a serious complication when treating patients experiencing ischemic stroke. Although the microRNA miR-27a-3p reportedly participates in ischemia/reperfusion (I/R) injury, its actions in CI/R remain unclear. To mimic CI/R in vitro, HT22 cells were subjected to oxygen glucose deprivation/reoxygenation (OGD/R). The results indicate that OGD inhibited growth and induced apoptosis among HT22 cells. The apoptosis was accompanied by increases in activated caspases 3 and 9 and decreases in Bcl...
Source: Aging - April 20, 2021 Category: Biomedical Science Authors: Wenyu Li Qiongbin Zhu Xiaoyan Xu Xingyue Hu Source Type: research
Agomelatine prevents macrophage infiltration and brain endothelial cell damage in a stroke mouse model
CONCLUSION: Agomelatine prevents macrophage infiltration and brain endothelial cell damage in a stroke mouse model.PMID:33839700 | DOI:10.18632/aging.202836
Source: Aging - April 11, 2021 Category: Biomedical Science Authors: Yiqiang Cao Fei Wang Yonggang Wang Jiang Long Source Type: research
lncRNA C2dat2 facilitates autophagy and apoptosis via the miR-30d-5p/DDIT4/mTOR axis in cerebral ischemia-reperfusion injury
This study first revealed that C2dat2/miR-30d-5p/DDIT4/mTOR forms a novel signaling pathway to facilitate autophagy and apoptosis induced by CIRI, contributing to the better understanding of the mechanisms of CIRI and enriching the ceRNA hypothesis in CIRI.PMID:33833132 | DOI:10.18632/aging.202824
Source: Aging - April 9, 2021 Category: Biomedical Science Authors: Qian Xu Ma Guohui Dandan Li Fanghui Bai Jintao Fang Gui Zhang Yuxin Xing Jiawei Zhou Yugang Guo Yunchao Kan Source Type: research
Association of vitamin D metabolites with cognitive function and brain atrophy in elderly individuals - the Austrian stroke prevention study
CONCLUSIONS: Vitamin D deficient individuals appear to have a modest reduction of memory function without structural brain atrophy. Future studies should explore if vitamin D supplementation can improve cognitive function.PMID:33825696 | DOI:10.18632/aging.202930
Source: Aging - April 7, 2021 Category: Biomedical Science Authors: Sieglinde Zelzer Edith Hofer Andreas Meinitzer Eva Fritz-Petrin Sebastian Simstich Walter Goessler Reinhold Schmidt Markus Herrmann Source Type: research
